Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease

Regulation of integrin-mediated adhesions

(2015) Daniel V Iwamoto et al.   CURRENT OPINION IN CELL BIOLOGY

Phospholipase C Epsilon (PLCε) Induced TRPC6 Activation: A Common but Redundant Mechanism in Primary Podocytes

(2015) Hermann Kalwa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes

(2015) Junnan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

(2015) Mario Schiffer et al.   NATURE MEDICINE

Glycogen Synthase Kinase 3β Dictates Podocyte Motility and Focal Adhesion Turnover by Modulating Paxillin Activity

(2014) Weiwei Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance

(2014) Xuefei Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhophilin-1 Is a Key Regulator of the Podocyte Cytoskeleton and Is Essential for Glomerular Filtration

(2014) M. A. Lal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli

(2014) Daria V. Ilatovskaya et al.   KIDNEY INTERNATIONAL

Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis

(2014) Eduardo H. Garin et al.   PEDIATRIC NEPHROLOGY

NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex

(2013) Eun Young Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

(2013) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

N-WASP Is Required for Stabilization of Podocyte Foot Processes

(2013) C. Schell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Two-Photon Microscopy Reveals Stationary Podocytes in Living Zebrafish Larvae

(2013) N. Endlich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

(2013) Simone M. Blattner et al.   KIDNEY INTERNATIONAL

Rac1 Activation in Podocytes Induces Rapid Foot Process Effacement and Proteinuria

(2013) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags

(2013) Matthias J Hackl et al.   NATURE MEDICINE

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis

(2013) Julia M. Hofstra et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Abatacept in B7-1–Positive Proteinuric Kidney Disease

(2013) Chih-Chuan Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease

(2013) Andrea Babelova et al.   PLoS One

Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through IntegrinαVβ3/FAK/PI3K Pathway-Mediated Rac1 Activation

(2013) Yi Lin et al.   Biomed Research International

The glomerular filtration barrier function

(2012) Ralf Hausmann et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Role of dynamin, synaptojanin, and endophilin in podocyte foot processes

(2012) Keita Soda et al.   JOURNAL OF CLINICAL INVESTIGATION

Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease

(2012) Britta George et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Integrin  2 1 Ameliorates Glomerular Injury

(2012) C. M. Borza et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte-Specific Loss of Cdc42 Leads to Congenital Nephropathy

(2012) R. P. Scott et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of the proteinuria induced by Rho GTPases

(2012) Liming Wang et al.   KIDNEY INTERNATIONAL

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli

(2011) Daria V. Ilatovskaya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

(2011) Changli Wei et al.   NATURE MEDICINE

MYO1EMutations and Childhood Familial Focal Segmental Glomerulosclerosis

(2011) Caterina Mele et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct dynamin–actin interactions regulate the actin cytoskeleton

(2010) Changkyu Gu et al.   EMBO JOURNAL

Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement

(2010) H. Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

(2009) Elizabeth J Brown et al.   NATURE GENETICS

Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration

(2008) Teruo Hidaka et al.   AMERICAN JOURNAL OF PATHOLOGY

β1 integrin expression by podocytes is required to maintain glomerular structural integrity

(2008) Ambra Pozzi et al.   DEVELOPMENTAL BIOLOGY

Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca2+-Activated K+ (BKCa) Channels: Role in BKCa Trafficking to the Surface of Cultured Podocytes

(2008) E. Y. Kim et al.   MOLECULAR PHARMACOLOGY

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

(2008) Christian Faul et al.   NATURE MEDICINE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin β1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus

(2007) Keizo Kanasaki et al.   DEVELOPMENTAL BIOLOGY