The right time to learn: mechanisms and optimization of spaced learning

Rescue of Impaired Long-Term Facilitation at Sensorimotor Synapses of Aplysia following siRNA Knockdown of CREB1

(2015) L. Zhou et al.   JOURNAL OF NEUROSCIENCE

The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3

(2015) Luana Fioriti et al.   NEURON

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

(2015) Silvia Pasini et al.   Cell Reports

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

(2015) M. Cuadrado-Tejedor et al.   Clinical Epigenetics

Dynamics of nascent and active zone ultrastructure as synapses enlarge during long-term potentiation in mature hippocampus

(2014) Maria Elizabeth Bell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A retrieved context account of spacing and repetition effects in free recall.

(2014) Lynn L. Siegel et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION

Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice

(2014) Guan Cao et al.   JOURNAL OF NEUROPHYSIOLOGY

Long-Term Memory Stabilized by Noise-Induced Rehearsal

(2014) Y. Wei et al.   JOURNAL OF NEUROSCIENCE

Manipulating a "Cocaine Engram" in Mice

(2014) H.-L. Hsiang et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Replay Captures the Unique Topological Structure of a Novel Environment

(2014) X. Wu et al.   JOURNAL OF NEUROSCIENCE

A Positive Autoregulatory BDNF Feedback Loop via C/EBP  Mediates Hippocampal Memory Consolidation

(2014) D. Bambah-Mukku et al.   JOURNAL OF NEUROSCIENCE

Simulations suggest pharmacological methods for rescuing long-term potentiation

(2014) Paul Smolen et al.   JOURNAL OF THEORETICAL BIOLOGY

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Visual stimuli recruit intrinsically generated cortical ensembles

(2014) J.-e. K. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice

(2014) Ronald R. Seese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of spaced vs. massed training in long-term object-identity and object-location recognition memory

(2013) Paola C. Bello-Medina et al.   BEHAVIOURAL BRAIN RESEARCH

Deficit in Long-Term Synaptic Plasticity Is Rescued by a Computationally Predicted Stimulus Protocol

(2013) R.-Y. Liu et al.   JOURNAL OF NEUROSCIENCE

MAPK Establishes a Molecular Context That Defines Effective Training Patterns for Long-Term Memory Formation

(2013) G. T. Philips et al.   JOURNAL OF NEUROSCIENCE

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

(2013) Gary T. Philips et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Epigenetic Mechanisms of Rubinstein–Taybi Syndrome

(2013) Elizabeth Park et al.   NEUROMOLECULAR MEDICINE

Synaptic Scaling Enables Dynamically Distinct Short- and Long-Term Memory Formation

(2013) Christian Tetzlaff et al.   PLoS Computational Biology

A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP

(2013) Satoshi Kida   Experimental Neurobiology

Regulation of cytoplasmic polyadenylation can generate a bistable switch

(2012) Naveed Aslam et al.   BMC Systems Biology

Integrin Dynamics Produce a Delayed Stage of Long-Term Potentiation and Memory Consolidation

(2012) A. H. Babayan et al.   JOURNAL OF NEUROSCIENCE

Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation

(2012) Gary Lynch et al.   NEUROPHARMACOLOGY

Synaptic evidence for the efficacy of spaced learning

(2012) E. A. Kramar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing Long-Term Memory Formation in Two Neurons of the Drosophila Brain

(2012) C.-C. Chen et al.   SCIENCE

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons of Aplysia

(2011) R.-Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia

(2011) R.-Y. Liu et al.   LEARNING & MEMORY

Computational design of enhanced learning protocols

(2011) Yili Zhang et al.   NATURE NEUROSCIENCE

What makes distributed practice effective?

(2010) Aaron S. Benjamin et al.   COGNITIVE PSYCHOLOGY

Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP

(2010) Jennifer N. Bourne et al.   HIPPOCAMPUS

Teaching in small portions dispersed over time enhances long-term knowledge retention

(2010) Maitreyi Raman et al.   MEDICAL TEACHER

Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation

(2010) MyungSook Kim et al.   PLoS Computational Biology

The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction

(2009) Mario R. Pagani et al.   CELL

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

PKC Differentially Translocates during Spaced and Massed Training in Aplysia

(2009) C. A. Farah et al.   JOURNAL OF NEUROSCIENCE

Spacing extinction trials alleviates renewal and spontaneous recovery

(2009) G. P. Urcelay et al.   LEARNING & BEHAVIOR

Awake replay of remote experiences in the hippocampus

(2009) Mattias P Karlsson et al.   NATURE NEUROSCIENCE

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Spaced initial stimulus familiarization enhances novelty preference in Long-Evans rats

(2008) Matthew J. Anderson et al.   BEHAVIOURAL PROCESSES

cAMP Response Element-Binding Protein 1 Feedback Loop Is Necessary for Consolidation of Long-Term Synaptic Facilitation in Aplysia

(2008) R.-Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

(2008) C. Dong et al.   LEARNING & MEMORY