Journal
METABOLITES
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/metabo11090608
Keywords
metabolic reprogramming; tumorigenesis; preneoplastic changes; lipotoxicity
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [R01-113377]
- Weitlauf Endowment for Cancer Research
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Clear cell renal cell carcinoma is the most common and deadly type of kidney cancer, characterized by large intracellular lipid deposits believed to result from lipid metabolic reprogramming in tumor cells. Obesity is an independent risk factor for this cancer, and may be linked to lipid accumulation and metabolic disturbances in noncancerous cells of the kidney.
Clear cell renal cell carcinoma is the most common and deadly type of cancer affecting the kidney, and is characterized histologically by large intracellular lipid deposits. These deposits are thought to result from lipid metabolic reprogramming occurring in tumor cells, but the exact mechanisms and implications of these metabolic alterations are incompletely understood. Obesity is an independent risk factor for clear cell renal cell carcinoma, and is also associated with lipid accumulation in noncancerous epithelial cells of the proximal tubule, where clear cell renal cell carcinoma originates. This article explores the potential link between obesity-associated renal lipid metabolic disturbances and lipid metabolic reprogramming in clear cell renal cell carcinoma, and discusses potential implications for future research.
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