The contribution of branching morphogenesis to kidney development and disease

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators

(2016) Lori L. O'Brien et al.   DEVELOPMENT

Exploring the genetic basis of early-onset chronic kidney disease

(2016) Asaf Vivante et al.   Nature Reviews Nephrology

Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis

(2016) Paul Riccio et al.   PLOS BIOLOGY

ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation

(2015) Elanor N. Wainwright et al.   DEVELOPMENTAL BIOLOGY

Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung

(2015) Hye Young Kim et al.   DEVELOPMENTAL CELL

Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan

(2015) Shuang Chen et al.   DEVELOPMENTAL CELL

Developmental Programming of Branching Morphogenesis in the Kidney

(2015) R. V. Sampogna et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Comparing and distinguishing the structure of biological branching

(2015) Timothy O. Lamberton et al.   JOURNAL OF THEORETICAL BIOLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Genetic, environmental and epigenetic factors involved in CAKUT

(2015) Nayia Nicolaou et al.   Nature Reviews Nephrology

Mechanically patterning the embryonic airway epithelium

(2015) Victor D. Varner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OrganIn VitroCulture: What Have We Learned about Early Kidney Development?

(2015) Aleksandra Rak-Raszewska et al.   Stem Cells International

Integrin Alpha 8 Recessive Mutations Are Responsible for Bilateral Renal Agenesis in Humans

(2014) Camille Humbert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An interplay of geometry and signaling enables robust lung branching morphogenesis

(2014) D. Menshykau et al.   DEVELOPMENT

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

(2014) Kieran M. Short et al.   DEVELOPMENTAL CELL

Eya1 Interacts with Six2 and Myc to Regulate Expansion of the Nephron Progenitor Pool during Nephrogenesis

(2014) Jinshu Xu et al.   DEVELOPMENTAL CELL

An integrated pipeline for the multidimensional analysis of branching morphogenesis

(2014) Alexander N Combes et al.   Nature Protocols

HNF1B-associated renal and extra-renal disease—an expanding clinical spectrum

(2014) Rhian L. Clissold et al.   Nature Reviews Nephrology

The Number of Fetal Nephron Progenitor Cells Limits Ureteric Branching and Adult Nephron Endowment

(2014) Cristina Cebrian et al.   Cell Reports

Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis

(2014) Akio Kobayashi et al.   Stem Cell Reports

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud

(2013) Adam Packard et al.   DEVELOPMENTAL CELL

Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease

(2013) Valerie A Luyckx et al.   LANCET

Stromal–epithelial crosstalk regulates kidney progenitor cell differentiation

(2013) Amrita Das et al.   NATURE CELL BIOLOGY

Renal progenitors: an evolutionary conserved strategy for kidney regeneration

(2013) Paola Romagnani et al.   Nature Reviews Nephrology

Spatial mapping and quantification of developmental branching morphogenesis

(2012) K. Short et al.   DEVELOPMENT

FGF9 and FGF20 Maintain the Stemness of Nephron Progenitors in Mice and Man

(2012) Hila Barak et al.   DEVELOPMENTAL CELL

Mutations inGRIP1cause Fraser syndrome

(2012) Maartje J Vogel et al.   JOURNAL OF MEDICAL GENETICS

Invasion of Distal Nephron Precursors Associates with Tubular Interconnection during Nephrogenesis

(2012) R. M. Kao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Alcohol exposure during late gestation: multiple developmental outcomes in sheep

(2012) K. Kenna et al.   Journal of Developmental Origins of Health and Disease

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

(2011) Courtney M. Karner et al.   DEVELOPMENT

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells

(2011) S. C. Boyle et al.   DEVELOPMENT

Nephron formation adopts a novel spatial topology at cessation of nephrogenesis

(2011) Bree A. Rumballe et al.   DEVELOPMENTAL BIOLOGY

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

(2011) Xuguang Nie et al.   DEVELOPMENTAL BIOLOGY

Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism

(2011) Shunsuke Tanigawa et al.   DEVELOPMENTAL BIOLOGY

Calcium/NFAT signalling promotes early nephrogenesis

(2011) S.F. Burn et al.   DEVELOPMENTAL BIOLOGY

SOX9 controls epithelial branching by activating RET effector genes during kidney development

(2011) Antoine Reginensi et al.   HUMAN MOLECULAR GENETICS

Human nephron number: implications for health and disease

(2011) John F. Bertram et al.   PEDIATRIC NEPHROLOGY

Spectrum of HNF1B Mutations in a Large Cohort of Patients Who Harbor Renal Diseases

(2010) L. Heidet et al.   Clinical Journal of the American Society of Nephrology

Prenatal Exposure to Alcohol Reduces Nephron Number and Raises Blood Pressure in Progeny

(2010) S. P. Gray et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tomographic quantification of branching morphogenesis and renal development

(2010) Kieran M. Short et al.   KIDNEY INTERNATIONAL

Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme

(2010) Y. Uchiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The early development of the kidney and implications for future health

(2010) W. E. Hoy et al.   Journal of Developmental Origins of Health and Disease

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10

(2010) Odyssé Michos et al.   PLoS Genetics

FREM1 Mutations Cause Bifid Nose, Renal Agenesis, and Anorectal Malformations Syndrome

(2009) Anas M. Alazami et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies

(2009) Sarah L. White et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

 1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity

(2009) X. Zhang et al.   DEVELOPMENT

The murine Fgfrl1 receptor is essential for the development of the metanephric kidney

(2009) Simon D. Gerber et al.   DEVELOPMENTAL BIOLOGY

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

(2009) Kylie Georgas et al.   DEVELOPMENTAL BIOLOGY

Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis

(2009) Xuan Chi et al.   DEVELOPMENTAL CELL

Three-Dimensional Imaging Reveals Ureteric and Mesenchymal Defects in Fgfr2-Mutant Kidneys

(2009) S. Sims-Lucas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MMP9 Limits Apoptosis and Stimulates Branching Morphogenesis During Kidney Development

(2009) C. Arnould et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

(2009) Benson C Lu et al.   NATURE GENETICS

Renal Aplasia in Humans Is Associated with RET Mutations

(2008) Michael A. Skinner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy

(2008) Matthew Harrison et al.   BRITISH JOURNAL OF NUTRITION

Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development

(2008) Akio Kobayashi et al.   Cell Stem Cell

Developmental plasticity and regenerative capacity in the renal ureteric bud/collecting duct system

(2008) D. Sweeney et al.   DEVELOPMENT

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney

(2008) Joshua W. Mugford et al.   DEVELOPMENTAL BIOLOGY

Canonical WNT/β-catenin signaling is required for ureteric branching

(2008) Darren Bridgewater et al.   DEVELOPMENTAL BIOLOGY

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

(2008) Eric W. Brunskill et al.   DEVELOPMENTAL CELL

Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli

(2008) J. E. Pitera et al.   HUMAN MOLECULAR GENETICS

SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development

(2008) S. Weber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The branching programme of mouse lung development

(2008) Ross J. Metzger et al.   NATURE

Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction

(2008) David Grote et al.   PLoS Genetics

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia

(2007) Scott Boyle et al.   DEVELOPMENTAL BIOLOGY

β-Catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state

(2007) Thomas D. Marose et al.   DEVELOPMENTAL BIOLOGY