Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

(2022) Hyojin Kim et al.   Nature Communications

Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

(2022) Russell A. Judge et al.   Nature Communications

Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism

(2022) Sara Dam Kobberø et al.   Nature Communications

Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

(2022) Qihang Zhong et al.   Cell Discovery

Semi-automated Optimization of the CHARMM36 Lipid Force Field to Include Explicit Treatment of Long-Range Dispersion

(2021) Yalun Yu et al.   Journal of Chemical Theory and Computation

Insulin-like growth factors: Ligands, binding proteins, and receptors

(2021) Derek LeRoith et al.   Molecular Metabolism

Short stature with low insulin‐like growth factor 1 availability due to pregnancy‐associated plasma protein A2 deficiency in a Saudi family

(2021) Amir Babiker et al.   CLINICAL GENETICS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

(2020) Chengdong Liu et al.   eLife

Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects

(2020) Masanobu Fujimoto et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Role of IGF-binding proteins in regulating IGF responses to changes in metabolism

(2018) David R Clemmons   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Developing a molecular dynamics force field for both folded and disordered protein states

(2018) Paul Robustelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

(2018) John B. Allard et al.   Frontiers in Endocrinology

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Non-Classical Congenital Adrenal Hyperplasia in Childhood

(2017) Selim Kurtoğlu et al.   Journal of Clinical Research in Pediatric Endocrinology

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

(2016) A. Dauber et al.   EMBO Molecular Medicine

Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity

(2015) Julian K. Christians et al.   GROWTH HORMONE & IGF RESEARCH

Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A

(2015) Søren Kløverpris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Water Dispersion Interactions Strongly Influence Simulated Structural Properties of Disordered Protein States

(2015) Stefano Piana et al.   JOURNAL OF PHYSICAL CHEMISTRY B

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Stanniocalcin-2 Inhibits Mammalian Growth by Proteolytic Inhibition of the Insulin-like Growth Factor Axis

(2014) Malene R. Jepsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

Pregnancy-associated Plasma Protein A (PAPP-A) Modulates the Early Developmental Rate in Zebrafish Independently of Its Proteolytic Activity

(2013) Kasper Kjaer-Sorensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A robust immunoassay for pregnancy-associated plasma protein-A2 based on analysis of circulating antigen: establishment of normal ranges in pregnancy

(2013) S. Kløverpris et al.   MOLECULAR HUMAN REPRODUCTION

IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A–IGFBP interaction sites

(2012) Ervinas Gaidamauskas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue Expression and Biological Consequences of Gene Knockout in Mice

(2011) Cheryl A. Conover et al.   ENDOCRINOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Involvement of Pregnancy-Associated Plasma Protein-A2 in Insulin-Like Growth Factor (IGF) Binding Protein-5 Proteolysis during Pregnancy: A Potential Mechanism for Increasing IGF Bioavailability

(2010) Xiaolang Yan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases

(2010) Walter Stöcker et al.   PROTEIN SCIENCE

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation