Technologies for imaging neural activity in large volumes

Improving data quality in neuronal population recordings

(2016) Kenneth D Harris et al.   NATURE NEUROSCIENCE

Simultaneous Multi-plane Imaging of Neural Circuits

(2016) Weijian Yang et al.   NEURON

Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data

(2016) Eftychios A. Pnevmatikakis et al.   NEURON

Dynamic wavefront shaping with an acousto-optic lens for laser scanning microscopy

(2016) George Konstantinou et al.   OPTICS EXPRESS

Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy

(2016) Peter Rupprecht et al.   Biomedical Optics Express

Sensitive red protein calcium indicators for imaging neural activity

(2016) Hod Dana et al.   eLife

Neural dynamics for landmark orientation and angular path integration

(2015) Johannes D. Seelig et al.   NATURE

Functional organization of excitatory synaptic strength in primary visual cortex

(2015) Lee Cossell et al.   NATURE

Continuous volumetric imaging via an optical phase-locked ultrasound lens

(2015) Lingjie Kong et al.   NATURE METHODS

Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs

(2015) Wenzhi Sun et al.   NATURE NEUROSCIENCE

A Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior

(2015) Simon P. Peron et al.   NEURON

Closed-Loop and Activity-Guided Optogenetic Control

(2015) Logan Grosenick et al.   NEURON

Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy

(2015) Walther Akemann et al.   OPTICS EXPRESS

Ultra-large field-of-view two-photon microscopy

(2015) Philbert S. Tsai et al.   OPTICS EXPRESS

Shaping field for 3D laser scanning microscopy

(2015) Jorge Colon et al.   OPTICS LETTERS

Deep two-photon brain imaging with a red-shifted fluorometric Ca2+indicator

(2015) Carsten Tischbirek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor

(2015) Y. Gong et al.   SCIENCE

Single-trial spike trains in parietal cortex reveal discrete steps during decision-making

(2015) K. W. Latimer et al.   SCIENCE

Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue

(2015) Kai Wang et al.   Nature Communications

Minimally invasive microendoscopy system for in vivo functional imaging of deep nuclei in the mouse brain

(2015) Miriam E. Bocarsly et al.   Biomedical Optics Express

Improved Estimation and Interpretation of Correlations in Neural Circuits

(2015) Dimitri Yatsenko et al.   PLoS Computational Biology

Neural coding in barrel cortex during whisker-guided locomotion

(2015) Nicholas James Sofroniew et al.   eLife

Mapping nonlinear receptive field structure in primate retina at single cone resolution

(2015) Jeremy Freeman et al.   eLife

Calcium transient prevalence across the dendritic arbour predicts place field properties

(2014) Mark E. J. Sheffield et al.   NATURE

Rapid adaptive optical recovery of optimal resolution over large volumes

(2014) Kai Wang et al.   NATURE METHODS

Mapping brain activity at scale with cluster computing

(2014) Jeremy Freeman et al.   NATURE METHODS

Multiplexed aberration measurement for deep tissue imaging in vivo

(2014) Chen Wang et al.   NATURE METHODS

Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data

(2014) Fernando Amat et al.   NATURE METHODS

Population code in mouse V1 facilitates readout of natural scenes through increased sparseness

(2014) Emmanouil Froudarakis et al.   NATURE NEUROSCIENCE

High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

(2014) François St-Pierre et al.   NATURE NEUROSCIENCE

Detecting cells using non-negative matrix factorization on calcium imaging data

(2014) Ryuichi Maruyama et al.   NEURAL NETWORKS

The Practical and Fundamental Limits of Optical Imaging in Mammalian Brains

(2014) Na Ji   NEURON

The Functional Micro-organization of Grid Cells Revealed by Cellular-Resolution Imaging

(2014) James G. Heys et al.   NEURON

Cellular resolution optical access to brain regions in fissures: Imaging medial prefrontal cortex and grid cells in entorhinal cortex

(2014) Ryan J. Low et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal lens design and use in laser-scanning microscopy

(2014) Adrian Negrean et al.   Biomedical Optics Express

Photon Shot Noise Limits on Optical Detection of Neuronal Spikes and Estimation of Spike Timing

(2013) Brian A. Wilt et al.   BIOPHYSICAL JOURNAL

Advanced Fiber Soliton Sources for Nonlinear Deep Tissue Imaging in Biophotonics

(2013) Ke Wang et al.   IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

High Speed Focus Control MEMS Mirror With Controlled Air Damping for Vital Microscopy

(2013) Mohammad J. Moghimi et al.   JOURNAL OF MICROELECTROMECHANICAL SYSTEMS

Online correction of licking-induced brain motion during two-photon imaging with a tunable lens

(2013) Jerry L. Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

(2013) Misha B Ahrens et al.   NATURE METHODS

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Cortico-cortical projections in mouse visual cortex are functionally target specific

(2013) Lindsey L Glickfeld et al.   NATURE NEUROSCIENCE

Speckle-scale focusing in the diffusive regime with time reversal of variance-encoded light (TROVE)

(2013) Benjamin Judkewitz et al.   Nature Photonics

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

(2013) Nicholas G. Horton et al.   Nature Photonics

Chronic Cellular Imaging of Entire Cortical Columns in Awake Mice Using Microprisms

(2013) Mark L. Andermann et al.   NEURON

Extended depth of field microscopy for rapid volumetric two-photon imaging

(2013) Gabrielle Thériault et al.   OPTICS EXPRESS

Characterization of spatially varying aberrations for wide field-of-view microscopy

(2013) Guoan Zheng et al.   OPTICS EXPRESS

Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo

(2013) D. N. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional mapping of microcircuit correlation structure

(2013) R. James Cotton et al.   Frontiers in Neural Circuits

Physical principles for scalable neural recording

(2013) Adam H. Marblestone et al.   Frontiers in Computational Neuroscience

Network Analysis of Corticocortical Connections Reveals Ventral and Dorsal Processing Streams in Mouse Visual Cortex

(2012) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Multiple dynamic representations in the motor cortex during sensorimotor learning

(2012) D. Huber et al.   NATURE

Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes

(2012) Gergely Katona et al.   NATURE METHODS

Imaging Calcium in Neurons

(2012) Christine Grienberger et al.   NEURON

Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates

(2012) E. J. Botcherby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated Tracking of Whiskers in Videos of Head Fixed Rodents

(2012) Nathan G. Clack et al.   PLoS Computational Biology

Heuristically optimal path scanning for high-speed multiphoton circuit imaging

(2011) Alexander J. Sadovsky et al.   JOURNAL OF NEUROPHYSIOLOGY

Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex

(2011) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Local Diversity and Fine-Scale Organization of Receptive Fields in Mouse Visual Cortex

(2011) V. Bonin et al.   JOURNAL OF NEUROSCIENCE

Functional mapping of single spines in cortical neurons in vivo

(2011) Xiaowei Chen et al.   NATURE

Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy

(2011) Robert P J Barretto et al.   NATURE MEDICINE

Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing

(2011) Adrian Cheng et al.   NATURE METHODS

Functional Specialization of Mouse Higher Visual Cortical Areas

(2011) Mark L. Andermann et al.   NEURON

Functional Specialization of Seven Mouse Visual Cortical Areas

(2011) James H. Marshel et al.   NEURON

Three-dimensional in vivo scanning microscopy with inertia-free focus control

(2011) Marco Dal Maschio et al.   OPTICS LETTERS

Agitation-free multiphoton microscopy of oblique planes

(2011) Christopher W. Smith et al.   OPTICS LETTERS

Adaptive optics confocal microscopy using direct wavefront sensing

(2011) Xiaodong Tao et al.   OPTICS LETTERS

Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons

(2011) Gergely Katona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

(2011) Z. Varga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and adaptive optical correction of aberrations during in vivo imaging in the mouse cortex

(2011) N. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast two-layer two-photon imaging of neuronal cell populations using an electrically tunable lens

(2011) Benjamin F. Grewe et al.   Biomedical Optics Express

Enhancing collection efficiency in large field of view multiphoton microscopy

(2010) J.D. MCMULLEN et al.   JOURNAL OF MICROSCOPY

Automatic Identification of Fluorescently Labeled Brain Cells for Rapid Functional Imaging

(2010) Ilya Valmianski et al.   JOURNAL OF NEUROPHYSIOLOGY

Chronic optical access through a polished and reinforced thinned skull

(2010) Patrick J Drew et al.   NATURE METHODS

High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision

(2010) Benjamin F Grewe et al.   NATURE METHODS

Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

(2010) Guang Yang et al.   Nature Protocols

Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual Cortex

(2010) Aaron M. Kerlin et al.   NEURON

A compact acousto-optic lens for 2D and 3D femtosecond based 2-photon microscopy

(2010) Paul A. Kirkby et al.   OPTICS EXPRESS

Microprisms for In Vivo Multilayer Cortical Imaging

(2009) Thomas H. Chia et al.   JOURNAL OF NEUROPHYSIOLOGY

Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues

(2009) Na Ji et al.   NATURE METHODS

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols

Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging Data

(2009) Eran A. Mukamel et al.   NEURON

Deep tissue multiphoton microscopy using longer wavelength excitation

(2009) Demirhan Kobat et al.   OPTICS EXPRESS

Enhanced fluorescence signal in nonlinear microscopy through supplementary fiber-optic light collection

(2009) Christoph J. Engelbrecht et al.   OPTICS EXPRESS

Fluorescence Changes of Genetic Calcium Indicators and OGB-1 Correlated with Neural Activity and Calcium In Vivo and In Vitro

(2008) T. Hendel et al.   JOURNAL OF NEUROSCIENCE

Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope

(2008) Yo Otsu et al.   JOURNAL OF NEUROSCIENCE METHODS

Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution

(2008) Kyle P. Lillis et al.   JOURNAL OF NEUROSCIENCE METHODS

Spatio-temporal correlations and visual signalling in a complete neuronal population

(2008) Jonathan W. Pillow et al.   NATURE

Three-dimensional random access multiphoton microscopy for functional imaging of neuronal activity

(2008) Gaddum Duemani Reddy et al.   NATURE NEUROSCIENCE

Inferring input nonlinearities in neural encoding models

(2008) Misha B. Ahrens et al.   NETWORK-COMPUTATION IN NEURAL SYSTEMS

Advancing multifocal nonlinear microscopy: development and application of a novel multibeam Yb:KGd(WO_4)_2 oscillator

(2008) Kraig E. Sheetz et al.   OPTICS EXPRESS

High-speed varifocal imaging with a tunable acoustic gradient index of refraction lens

(2008) Alexandre Mermillod-Blondin et al.   OPTICS LETTERS

An optical technique for remote focusing in microscopy

(2007) E.J. Botcherby et al.   OPTICS COMMUNICATIONS