TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

(2014) Daniel P. Flaherty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia

(2014) Aida Platero-Luengo et al.   CELL

Increase in cytosolic Ca2+produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body

(2014) Dawon Kang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors

(2014) Colin A. Nurse   JOURNAL OF PHYSIOLOGY-LONDON

Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca2+ concentration in rat carotid body glomus cells

(2014) Donghee Kim et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors

(2014) Bettina U. Wilke et al.   Nature Communications

TASK-1 (KCNK3) and TASK-3 (KCNK9) Tandem Pore Potassium Channel Antagonists Stimulate Breathing in Isoflurane-Anesthetized Rats

(2013) Joseph F. Cotten   ANESTHESIA AND ANALGESIA

Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension

(2013) Julian F. R. Paton et al.   CURRENT HYPERTENSION REPORTS

The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia

(2013) Mary E. Slingo et al.   JOURNAL OF APPLIED PHYSIOLOGY

Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells

(2013) Keith J. Buckler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2

(2013) Tammie Bishop et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells

(2013) Philip J. Turner et al.   JOURNAL OF PHYSIOLOGY-LONDON

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension

(2013) Fiona D. McBryde et al.   Nature Communications

The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis

(2012) Stefan Bittner et al.   EXPERIMENTAL NEUROLOGY

The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases

(2012) Julian F.R. Paton et al.   HYPERTENSION

Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat

(2012) Ana P. Abdala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells

(2012) Keith J. Buckler   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species

(2012) Justin R. Papreck et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Carbon monoxide (CO) and hydrogen sulfide (H2S) in hypoxic sensing by the carotid body

(2012) Nanduri R. Prabhakar   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells

(2011) Teresa Gallego-Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia: developments in basic science, physiology and clinical studies

(2011) D. S. Ward et al.   ANAESTHESIA

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Probing the regulation of TASK potassium channels by PI(4,5)P2with switchable phosphoinositide phosphatases

(2011) Moritz Lindner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Changes in oxygen sensitivity of TASK in carotid body glomus cells during early postnatal development

(2011) Donghee Kim et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Carotid body chemosensory responses in mice deficient of TASK channels

(2010) Patricia Ortega-Sáenz et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

H2S mediates O2 sensing in the carotid body

(2010) Y.-J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Sulfide and Oxygen Sensing in the Cardiovascular System

(2009) Kenneth R. Olson et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells † †This work was presented in part at the 82nd Annual Meeting of the International Anesthetic Research Society, San Francisco, CA, USA, March 29–April 1, 2008.

(2009) J.J. Pandit et al.   BRITISH JOURNAL OF ANAESTHESIA

Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+channel in rat carotid body glomus cells

(2009) Donghee Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMP-activated protein kinase inhibits TREK channels

(2009) Orsolya Kréneisz et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Role for TASK-1 (KCNK3) Channels in the Chemosensory Control of Breathing

(2008) S. Trapp et al.   JOURNAL OF NEUROSCIENCE

Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide

(2007) E L Veale et al.   BRITISH JOURNAL OF PHARMACOLOGY