Developmental timing and critical windows for the treatment of psychiatric disorders

Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits

(2016) Susanna B. Mierau et al.   BIOLOGICAL PSYCHIATRY

Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype

(2016) Annarita Patrizi et al.   BIOLOGICAL PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Altering the course of schizophrenia: progress and perspectives

(2016) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition

(2016) Makoto Tamura et al.   NEURON

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

(2016) Elizabeth Berry-Kravis et al.   Science Translational Medicine

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier

(2016) Shafali S. Jeste et al.   Science Translational Medicine

Rett Syndrome: Crossing the Threshold to Clinical Translation

(2016) David M. Katz et al.   TRENDS IN NEUROSCIENCES

Outcomes of Nontransitioned Cases in a Sample at Ultra-High Risk for Psychosis

(2015) Ashleigh Lin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Forecasting Psychosis by Event-Related Potentials—Systematic Review and Specific Meta-Analysis

(2015) Mitja Bodatsch et al.   BIOLOGICAL PSYCHIATRY

Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons

(2015) Hirofumi Morishita et al.   BIOLOGICAL PSYCHIATRY

Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity

(2015) Jeremy Hall et al.   BIOLOGICAL PSYCHIATRY

Critical period for first language: the crucial role of language input during the first year of life

(2015) Naama Friedmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Autism spectrum disorders: from genes to neurobiology

(2015) A Jeremy Willsey et al.   CURRENT OPINION IN NEUROBIOLOGY

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome

(2015) Sebastian H Scharf et al.   CURRENT OPINION IN PHARMACOLOGY

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Modeling psychiatric disorders for developing effective treatments

(2015) Tobias Kaiser et al.   NATURE MEDICINE

Treatment during a vulnerable developmental period rescues a genetic epilepsy

(2015) Stephan Lawrence Marguet et al.   NATURE MEDICINE

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine

(2015) Il Hwan Kim et al.   NATURE NEUROSCIENCE

Is birth a critical period in the pathogenesis of autism spectrum disorders?

(2015) Yehezkel Ben-Ari   NATURE REVIEWS NEUROSCIENCE

Molecular Substrates of Altered Axonal Growth and Brain Connectivity in a Mouse Model of Schizophrenia

(2015) Jun Mukai et al.   NEURON

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex

(2015) Keerthi Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult cortical plasticity depends on an early postnatal critical period

(2015) S. D. Greenhill et al.   SCIENCE

Translating the MAM model of psychosis to humans

(2015) Gemma Modinos et al.   TRENDS IN NEUROSCIENCES

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

(2014) Maude Schneider et al.   AMERICAN JOURNAL OF PSYCHIATRY

Neuronal Plasticity: Beyond the Critical Period

(2014) Mark Hübener et al.   CELL

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Family-Focused Treatment for Adolescents and Young Adults at High Risk for Psychosis: Results of a Randomized Trial

(2014) David J. Miklowitz et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

(2014) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Juvenile Antioxidant Treatment Prevents Adult Deficits in a Developmental Model of Schizophrenia

(2014) Jan-Harry Cabungcal et al.   NEURON

Intervention in the Context of Development: Pathways Toward New Treatments

(2014) Jeremy Veenstra-VanderWeele et al.   NEUROPSYCHOPHARMACOLOGY

Development of pattern vision following early and extended blindness

(2014) Amy Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a Psychosis Risk Blood Diagnostic for Persons Experiencing High-Risk Symptoms: Preliminary Results From the NAPLS Project

(2014) Diana O. Perkins et al.   SCHIZOPHRENIA BULLETIN

Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia

(2014) Christina Andreou et al.   SCHIZOPHRENIA BULLETIN

Adolescent mental health--Opportunity and obligation

(2014) F. S. Lee et al.   SCIENCE

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function

(2014) H. Hu et al.   SCIENCE

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

The impact of environmental factors in severe psychiatric disorders

(2014) Andrea Schmitt et al.   Frontiers in Neuroscience

Using Structural Neuroimaging to Make Quantitative Predictions of Symptom Progression in Individuals at Ultra-High Risk for Psychosis

(2014) Stefania Tognin et al.   Frontiers in Psychiatry

N-Acetylcysteine as an Adjunct to Risperidone for Treatment of Negative Symptoms in Patients With Chronic Schizophrenia

(2013) Mehdi Farokhnia et al.   CLINICAL NEUROPHARMACOLOGY

Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice

(2013) H. Kim et al.   JOURNAL OF NEUROSCIENCE

Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism

(2013) Warren Jones et al.   NATURE

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Circuit level defects in the developing neocortex of Fragile X mice

(2013) J Tiago Gonçalves et al.   NATURE NEUROSCIENCE

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

(2013) Lowry A. Kirkby et al.   NEURON

A Theory of the Transition to Critical Period Plasticity: Inhibition Selectively Suppresses Spontaneous Activity

(2013) Taro Toyoizumi et al.   NEURON

Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes

(2013) Isabel del Pino et al.   NEURON

GABAergic Interneurons Shape the Functional Maturation of the Cortex

(2013) Corentin Le Magueresse et al.   NEURON

Imaging Patients with Psychosis and a Mouse Model Establishes a Spreading Pattern of Hippocampal Dysfunction and Implicates Glutamate as a Driver

(2013) Scott A. Schobel et al.   NEURON

Peripubertal Diazepam Administration Prevents the Emergence of Dopamine System Hyperresponsivity in the MAM Developmental Disruption Model of Schizophrenia

(2013) Yijuan Du et al.   NEUROPSYCHOPHARMACOLOGY

Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies

(2013) P. Fusar-Poli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Evidence for dysregulated high-frequency oscillations during sensory processing in medication-naïve, first episode schizophrenia

(2013) Limin Sun et al.   SCHIZOPHRENIA RESEARCH

Increased Hippocampal Glutamate and Volumetric Deficits in Unmedicated Patients With Schizophrenia

(2013) Nina V. Kraguljac et al.   JAMA Psychiatry

Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis

(2013) C A Bousman et al.   Translational Psychiatry

Regulating Critical Period Plasticity: Insight from the Visual System to Fear Circuitry for Therapeutic Interventions

(2013) Elisa M. Nabel et al.   Frontiers in Psychiatry

Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants With Autism

(2012) Jason J. Wolff et al.   AMERICAN JOURNAL OF PSYCHIATRY

Predicting Psychosis

(2012) Paolo Fusar-Poli   ARCHIVES OF GENERAL PSYCHIATRY

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

(2012) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

Glutamate and Psychosis Risk

(2012) Alice Egerton et al.   CURRENT PHARMACEUTICAL DESIGN

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

(2012) Sally M. Till et al.   HUMAN MOLECULAR GENETICS

Brain Activity Mapping in Mecp2 Mutant Mice Reveals Functional Deficits in Forebrain Circuits, Including Key Nodes in the Default Mode Network, that are Reversed with Ketamine Treatment

(2012) M. Kron et al.   JOURNAL OF NEUROSCIENCE

Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review

(2012) Michael K Mwaniki et al.   LANCET

Neurodevelopmental model of schizophrenia: update 2012

(2012) J L Rapoport et al.   MOLECULAR PSYCHIATRY

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap

(2012) Judith Pratt et al.   NATURE REVIEWS DRUG DISCOVERY

NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

(2012) Severine Durand et al.   NEURON

Early Cognitive Experience Prevents Adult Deficits in a Neurodevelopmental Schizophrenia Model

(2012) Heekyung Lee et al.   NEURON

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Assessing Executive Function in Preschoolers

(2012) Peter J. Anderson et al.   NEUROPSYCHOLOGY REVIEW

Capturing the Angel in "Angel Dust": Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans

(2012) B. Moghaddam et al.   SCHIZOPHRENIA BULLETIN

HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia

(2012) C.M. Corcoran et al.   SCHIZOPHRENIA RESEARCH

Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

(2012) E. M. Berry-Kravis et al.   Science Translational Medicine

A randomised controlled trial of bumetanide in the treatment of autism in children

(2012) E Lemonnier et al.   Translational Psychiatry

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

Animal models of schizophrenia

(2011) CA Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice

(2011) Takenao Koseki et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Weight Gain and Metabolic Risks Associated with Antipsychotic Medications in Children and Adolescents

(2011) Lawrence Maayan et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Global burden of disease in young people aged 10–24 years: a systematic analysis

(2011) Fiona M Gore et al.   LANCET

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study

(2011) O Howes et al.   MOLECULAR PSYCHIATRY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

(2011) David A. Lewis et al.   TRENDS IN NEUROSCIENCES

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

(2010) Ansgar M. Brambrink et al.   ANESTHESIOLOGY

Proton Magnetic Resonance Spectroscopy and Illness Stage in Schizophrenia—A Systematic Review and Meta-Analysis

(2010) Stefan Brugger et al.   BIOLOGICAL PSYCHIATRY

Redox Dysregulation Affects the Ventral But Not Dorsal Hippocampus: Impairment of Parvalbumin Neurons, Gamma Oscillations, and Related Behaviors

(2010) P. Steullet et al.   JOURNAL OF NEUROSCIENCE

Delayed Stabilization of Dendritic Spines in Fragile X Mice

(2010) A. Cruz-Martin et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia: The making of a troubled mind

(2010) David Dobbs   NATURE

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

(2010) Torfi Sigurdsson et al.   NATURE

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

(2010) Maria Karayiorgou et al.   NATURE REVIEWS NEUROSCIENCE

Critical Period Plasticity Matches Binocular Orientation Preference in the Visual Cortex

(2010) Bor-Shuen Wang et al.   NEURON

Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice

(2010) Emily G. Harlow et al.   NEURON

Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome

(2010) Tao Su et al.   PSYCHOPHARMACOLOGY

Neural synchrony and the development of cortical networks

(2010) Peter J. Uhlhaas et al.   TRENDS IN COGNITIVE SCIENCES

Redox dysregulation, neurodevelopment, and schizophrenia

(2009) Kim Q Do et al.   CURRENT OPINION IN NEUROBIOLOGY

Psychiatric Disorders and Intellectual Functioning Throughout Development in Velocardiofacial (22q11.2 Deletion) Syndrome

(2009) Tamar Green et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Schizophrenia

(2009) Jim van Os et al.   LANCET

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

(2009) Matthew B. Johnson et al.   NEURON

Sparsification of neuronal activity in the visual cortex at eye-opening

(2009) N. L. Rochefort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

(2008) Jay R. Gibson et al.   JOURNAL OF NEUROPHYSIOLOGY

Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice

(2008) I. Bureau et al.   JOURNAL OF NEUROSCIENCE

Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study

(2008) Béatrice Larroque et al.   LANCET

Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis

(2008) Stefan Leucht et al.   LANCET

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

Reversing Neurodevelopmental Disorders in Adults

(2008) Dan Ehninger et al.   NEURON

Advances in the Treatment of Fragile X Syndrome

(2008) R. J. Hagerman et al.   PEDIATRICS