Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity

Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms

(2016) Nirmalya Saha et al.   BMC GENOMICS

The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3

(2016) Ambikai Gajan et al.   Epigenetics & Chromatin

Inherited 15q24 microdeletion syndrome in twins and their father with phenotypic variability

(2015) Lena Samuelsson et al.   European Journal of Medical Genetics

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex

(2015) Keerthi Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBR1is the candidate gene for intellectual disability in patients with a 2q24.2 interstitial deletion

(2014) Orazio Palumbo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Progenitor genealogy in the developing cerebral cortex

(2014) Sophie Laguesse et al.   CELL AND TISSUE RESEARCH

The Wnt cries many: Wnt regulation of neurogenesis through tissue patterning, proliferation, and asymmetric cell division

(2014) Holger Bielen et al.   Developmental Neurobiology

CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression

(2014) Q. Ji et al.   JOURNAL OF CELL SCIENCE

Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures

(2014) W. Zhang et al.   JOURNAL OF NEUROSCIENCE

Malformations of cortical development: clinical features and genetic causes

(2014) Renzo Guerrini et al.   LANCET NEUROLOGY

Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders

(2014) D Schubert et al.   MOLECULAR PSYCHIATRY

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Genome sequencing identifies major causes of severe intellectual disability

(2014) Christian Gilissen et al.   NATURE

Refining analyses of copy number variation identifies specific genes associated with developmental delay

(2014) Bradley P Coe et al.   NATURE GENETICS

A framework for the interpretation of de novo mutation in human disease

(2014) Kaitlin E Samocha et al.   NATURE GENETICS

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality

(2014) Tzyy-Nan Huang et al.   NATURE NEUROSCIENCE

Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex

(2014) Takashi Namba et al.   NEURON

The genetics of cognitive epigenetics

(2014) Tjitske Kleefstra et al.   NEUROPHARMACOLOGY

Transcriptional co-repressors and memory storage

(2014) Hannah Schoch et al.   NEUROPHARMACOLOGY

De novo TBR1 mutations in sporadic autism disrupt protein functions

(2014) Pelagia Deriziotis et al.   Nature Communications

Growth of the Developing Cerebral Cortex Is Controlled by MicroRNA-7 through the p53 Pathway

(2014) Andrew Pollock et al.   Cell Reports

Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex

(2014) Dan Xu et al.   Cell Reports

Integrative Mechanisms of Oriented Neuronal Migration in the Developing Brain

(2013) Irina Evsyukova et al.   Annual Review of Cell and Developmental Biology

MeCP2 phosphorylation in the brain: from transcription to behavior

(2013) Daniela Damen et al.   BIOLOGICAL CHEMISTRY

Making headway with genetic diagnostics of intellectual disabilities

(2013) M.H. Willemsen et al.   CLINICAL GENETICS

Sin3: Insight into its transcription regulatory functions

(2013) Rama Kadamb et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease

(2012) Bridget E LaMonica et al.   CURRENT OPINION IN NEUROBIOLOGY

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

(2012) Shannon J. Gallagher et al.   DEVELOPMENTAL BIOLOGY

Emerging roles of neural stem cells in cerebral cortex development and evolution

(2012) Víctor Borrell et al.   Developmental Neurobiology

Chromosome 15q24 microdeletion syndrome

(2012) Pilar L. Magoulas et al.   Orphanet Journal of Rare Diseases

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Sin3a is essential for the genome integrity and viability of pluripotent cells

(2011) Patrick McDonel et al.   DEVELOPMENTAL BIOLOGY

Upregulation of E2F1 in cerebellar neuroprogenitor cells and cell cycle arrest during postnatal brain development

(2011) Daniela E. Suzuki et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability

(2011) M. H. Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Further clinical and molecular delineation of the 15q24 microdeletion syndrome

(2011) Heather C Mefford et al.   JOURNAL OF MEDICAL GENETICS

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

(2011) Elisabete M. Nascimento et al.   NATURE CELL BIOLOGY

Spatiotemporal Molecular Approach of in utero Electroporation to Functionally Decipher Endophenotypes in Neurodevelopmental Disorders

(2011) Sharon Margriet Kolk et al.   Frontiers in Molecular Neuroscience

Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons

(2010) Lorelei D. Shoemaker et al.   BIOESSAYS

Correlations between neurophysiological, behavioral, and cognitive function in Rett syndrome

(2010) Aglaia Vignoli et al.   EPILEPSY & BEHAVIOR

Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement

(2010) Lynn K. Paul   Journal of Neurodevelopmental Disorders

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

(2010) F. Bedogni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype–phenotype correlation in four 15q24 deleted patients identified by array-CGH

(2009) Joris Andrieux et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling

(2009) H. A. North et al.   DEVELOPMENT

A Positive Regulatory Role for the mSin3A-HDAC Complex in Pluripotency through Nanog and Sox2

(2009) Gretchen A. Baltus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons

(2009) Yumiko Hatanaka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Semaphorin 3F Is a Bifunctional Guidance Cue for Dopaminergic Axons and Controls Their Fasciculation, Channeling, Rostral Growth, and Intracortical Targeting

(2009) S. M. Kolk et al.   JOURNAL OF NEUROSCIENCE

Regulation of cell proliferation and wing development by Drosophila SIN3 and String

(2009) Aishwarya Swaminathan et al.   MECHANISMS OF DEVELOPMENT

The determination of projection neuron identity in the developing cerebral cortex

(2008) Dino P Leone et al.   CURRENT OPINION IN NEUROBIOLOGY

Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian development

(2008) Patrick McDonel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Making bigger brains-the evolution of neural-progenitor-cell division

(2008) J. L. Fish et al.   JOURNAL OF CELL SCIENCE

Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis

(2008) Stephen C. Noctor et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Role for Mammalian Sin3 in Permanent Gene Silencing

(2008) Chris van Oevelen et al.   MOLECULAR CELL

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

(2008) Jiancong Liang et al.   NATURE CELL BIOLOGY