Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

(2022) Daniel A. Michelson et al.   CELL

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

(2021) Jhoanne L. Bautista et al.   Nature Communications

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Liver X receptors are required for thymic resilience and T cell output

(2020) Christopher T. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progesterone modulates the T cell response via glucocorticoid receptor-dependent pathways

(2019) Alexandra Maximiliane Hierweger et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

(2019) Matthew D. Taves et al.   Cell Reports

The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction

(2019) Marie-Charlotte Meinsohn et al.   PHYSIOLOGICAL REVIEWS

The MetaCyc database of metabolic pathways and enzymes - a 2019 update

(2019) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

(2019) Izumi Ohigashi et al.   Cell Reports

Pathway Tools version 23.0 update: software for pathway/genome informatics and systems biology

(2019) Peter D Karp et al.   BRIEFINGS IN BIOINFORMATICS

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

(2019) Jennifer E. Cowan et al.   Nature Communications

Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection

(2018) Paul R. Mittelstadt et al.   JOURNAL OF IMMUNOLOGY

Rapid chromatin repression by Aire provides precise control of immune tolerance

(2018) Andrew S. Koh et al.   NATURE IMMUNOLOGY

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Steroidogenesis: Unanswered Questions

(2017) Walter L. Miller   TRENDS IN ENDOCRINOLOGY AND METABOLISM

T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites

(2017) Lourdes Rocamora-Reverte et al.   Cell Death & Disease

Lymphoid organs of neonatal and adult mice preferentially produce active glucocorticoids from metabolites, not precursors

(2016) Matthew D. Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Retinoids induce Nur77-dependent apoptosis in mouse thymocytes

(2015) Beáta Kiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Vesicle-Mediated Steroid Hormone Secretion in Drosophila melanogaster

(2015) Naoki Yamanaka et al.   CELL

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance

(2015) Hiroyuki Takaba et al.   CELL

Steroid Profiling Reveals Widespread Local Regulation of Glucocorticoid Levels During Mouse Development

(2015) Matthew D. Taves et al.   ENDOCRINOLOGY

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

(2015) María Emilia Solano et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells

(2015) Katsuhiro Sasaki et al.   Nature Communications

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

(2014) Haydn T. Kissick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory and Immunoregulatory Roles of Eicosanoids in T Cells

(2013) Anna Mari Lone et al.   Frontiers in Immunology

Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness

(2012) Paul R. Mittelstadt et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic nurse cells provide microenvironment for secondary T cell receptor   rearrangement in cortical thymocytes

(2012) Y. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens

(2012) Xiaoping Wang et al.   Frontiers in Immunology

Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function

(2011) Matthew D. Taves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

(2011) Yu Lei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

(2011) M. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract

(2011) W. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription

(2010) K Tóth et al.   CELL DEATH AND DIFFERENTIATION

TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis

(2010) Mario Noti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymocyte-Synthesized Glucocorticoids Play a Role in Thymocyte Homeostasis and Are Down-Regulated by Adrenocorticotropic Hormone

(2009) Shengjun Qiao et al.   ENDOCRINOLOGY

Thymus-specific serine protease regulates positive selection of a subset of CD4+thymocytes

(2009) Julien Gommeaux et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4+ Thymocytes

(2009) M. Laan et al.   JOURNAL OF IMMUNOLOGY

Age-related synthesis of glucocorticoids in thymocytes

(2008) Shengjun Qiao et al.   EXPERIMENTAL CELL RESEARCH

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

Evolutionarily conserved and divergent regions of the Autoimmune Regulator (Aire) gene: a comparative analysis

(2008) Mark Saltis et al.   IMMUNOGENETICS

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines

(2008) Gordana Leposavić et al.   NEUROIMMUNOMODULATION