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Title
HTS discovery of PARP1-HPF1 complex inhibitors in cancer
Authors
Keywords
-
Journal
SLAS Discovery
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2023-10-14
DOI
10.1016/j.slasd.2023.10.003
References
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Related references
Note: Only part of the references are listed.- Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1
- (2023) T. A. Kurgina et al. MOLECULAR BIOLOGY
- Inhibitors of PARP: Number crunching and structure gazing
- (2022) Johannes Rudolph et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
- (2021) Fa-Hui Sun et al. Nature Communications
- Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs
- (2021) Johannes Rudolph et al. Nature Communications
- HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
- (2021) Johannes Rudolph et al. eLife
- PARP1: Structural insights and pharmacological targets for inhibition
- (2021) Jacob O. Spiegel et al. DNA REPAIR
- Understanding and overcoming resistance to PARP inhibitors in cancer therapy
- (2021) Mariana Paes Dias et al. Nature Reviews Clinical Oncology
- Serine-linked PARP1 auto-modification controls PARP inhibitor response
- (2021) Evgeniia Prokhorova et al. Nature Communications
- Progress and outlook in studying the substrate specificities of PARPs and related enzymes
- (2020) Marcin J. Suskiewicz et al. FEBS Journal
- PARP inhibitor resistance: the underlying mechanisms and clinical implications
- (2020) He Li et al. Molecular Cancer
- Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism
- (2018) Johannes Rudolph et al. eLife
- PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
- (2018) Marie-France Langelier et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- PARP inhibitors: Clinical utility and possibilities of overcoming resistance
- (2017) Benjamin G. Bitler et al. GYNECOLOGIC ONCOLOGY
- HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
- (2016) Ian Gibbs-Seymour et al. MOLECULAR CELL
- Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance
- (2015) Peter Bai MOLECULAR CELL
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
- (2012) J. Murai et al. CANCER RESEARCH
- New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
- (2012) Bryan A. Gibson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
- (2011) Thomas Helleday Molecular Oncology
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