Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Lysoplex: An efficient toolkit to detect DNA sequence variations in the autophagy-lysosomal pathway

(2015) Giuseppina Di Fruscio et al.   Autophagy

Mendelian disorders of PI metabolizing enzymes

(2015) Leopoldo Staiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands

(2015) Sudesh Pawaria et al.   JOURNAL OF IMMUNOLOGY

ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking

(2015) Jing-Yiing Wu et al.   Journal of Innate Immunity

Immune dysfunction in Niemann-Pick disease type C

(2015) Nick Platt et al.   JOURNAL OF NEUROCHEMISTRY

The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule

(2015) Francesca Oltrabella et al.   PLoS Genetics

Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies

(2014) Michelle Pirruccello et al.   ACS Chemical Biology

Autophagy in the physiology and pathology of the central nervous system

(2014) V Nikoletopoulou et al.   CELL DEATH AND DIFFERENTIATION

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

The Cellular and Physiological Functions of the Lowe Syndrome Protein OCRL1

(2014) Zenobia B. Mehta et al.   TRAFFIC

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

(2014) Ramiro Nández et al.   eLife

Syntaxin 17

(2013) Eisuke Itakura et al.   Autophagy

Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver

(2013) Evie H. Carchman et al.   FASEB JOURNAL

Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location

(2013) Tu Thi Ngoc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens

(2012) Sylvain Ladoire et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

The UCSC genome browser and associated tools

(2012) R. M. Kuhn et al.   BRIEFINGS IN BIOINFORMATICS

The lipid kinase PI4KIIIβ preserves lysosomal identity

(2012) Sunandini Sridhar et al.   EMBO JOURNAL

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells

(2012) Yanggang Yuan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Impaired neural development in a zebrafish model for Lowe syndrome

(2011) Irene Barinaga-Rementeria Ramirez et al.   HUMAN MOLECULAR GENETICS

Role of TRP Channels in the Regulation of the Endosomal Pathway

(2011) Ken Abe et al.   PHYSIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Small Molecule Activators of TRPML3

(2010) Christian Grimm et al.   CHEMISTRY & BIOLOGY

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Oculocerebrorenal syndrome of Lowe: magnetic resonance imaging findings in the first six years of life

(2009) Arnolfo de Carvalho-Neto et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

(2009) Yuxin Mao et al.   EMBO JOURNAL

Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms

(2009) Rawshan Choudhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagic dysfunction in mucolipidosis type IV patients

(2008) Silvia Vergarajauregui et al.   HUMAN MOLECULAR GENETICS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY