Depolymerization of actin filaments by Cucurbitacin I through binding G‐actin

Cucurbitacin-B inhibits cancer cell migration by targeting mortalin and HDM2: computational and in vitro experimental evidence

(2023) He Huifu et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Anti-microbial, anti-oxidant and wound healing capabilities of Aloe vera-incorporated hybrid nanoflowers

(2023) Cevahir Altinkaynak et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement

(2023) Ajay Kumar et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Antiviral Compound PSP Inhibits HIV-1 Entry via PKR-Dependent Activation in Monocytic Cells

(2023) Eduardo Alvarez-Rivera et al.   Viruses-Basel

Thermott: A comprehensive online tool for protein–ligand binding constant determination

(2022) Marius Gedgaudas et al.   DRUG DISCOVERY TODAY

Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK / STAT3 , MAPK / ERK , and AKT / mTOR signaling pathways in HepG2 cell line

(2022) Nuray Üremiş et al.   JOURNAL OF FOOD BIOCHEMISTRY

Pharmacokinetics and Biological Activity of Cucurbitacins

(2022) Eugenia Elisa Delgado-Tiburcio et al.   Pharmaceuticals

Kopsanone inhibits proliferation and migration of invasive colon cancer cells

(2021) Daniella Paiva Bonfim et al.   PHYTOTHERAPY RESEARCH

Phyto-constituents profiling of Luffa echinata and in vitro assessment of antioxidant, anti-diabetic, anticancer and anti-acetylcholine esterase activities

(2021) Suraj B. Patel et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Connecting the dots in the mechanism of action of Cucurbitacin E (CurE) – path analysis and steered molecular dynamics reveal the precise site of entry and the passage of CurE in filamentous actin

(2019) L. Roopa et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

An overview of pharmacodynamic modelling, ligand-binding approach and its application in clinical practice

(2017) Mohammed Saji Salahudeen et al.   SAUDI PHARMACEUTICAL JOURNAL

Docking, molecular dynamics and QM/MM studies to delineate the mode of binding of CucurbitacinE to F-actin

(2016) R. Pravin Kumar et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Comprehensive evaluation of ten docking programs on a diverse set of protein–ligand complexes: the prediction accuracy of sampling power and scoring power

(2016) Zhe Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway

(2016) Yao Wu et al.   TOXICOLOGY LETTERS

The Natural Product Cucurbitacin E Inhibits Depolymerization of Actin Filaments

(2012) Pia M. Sörensen et al.   ACS Chemical Biology

Biological activities and potential molecular targets of cucurbitacins

(2012) Xiuping Chen et al.   ANTI-CANCER DRUGS

Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells

(2011) Y. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

On diphtheria toxin fragment A release into the cytosol—Cytochalasin D effect and involvement of actin filaments and eukaryotic elongation factor 2

(2011) Muhammet Bektaş et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cucurbitacin: Ancient Compound Shedding New Light on Cancer Treatment

(2011) Dhong Hyun Lee et al.   TheScientificWorldJOURNAL

Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics

(2010) David A. Knecht et al.   PLoS One

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY