News Item
Biotechnology & Applied Microbiology
Ken Garber
Summary: Pharma and biotech companies are utilizing mRNA technology to produce therapeutic proteins post COVID-19 vaccine success, bringing new hope for future medical developments.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Pharmacology & Pharmacy
Lei Lin, Lei Miao, Huiran Lin, Jiwen Cheng, Meng Li, Zhenjian Zhuo, Jing He
Summary: Neuroblastoma is a common solid tumor in children that poses challenges to current therapies. Personalized treatment and new therapies targeting RAS mutations hold promise for improving treatment outcomes. This review article focuses on the biological role and frequency of RAS mutations in neuroblastoma, as well as the strategies and progress in targeting RAS in preclinical and clinical settings, and discusses possible future prospects and challenges.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Anna Tavridou, Dolca Rogers, Milton Bonelli, Anja Schiel, Ana Hidalgo-Simon
Summary: Seeking scientific advice earlier and more frequently can help advanced therapy medicinal product developers avoid delays at the marketing authorisation stage. Carefully addressing quality and nonclinical issues before entering the pivotal development phase will pave the way for smooth clinical development and successful marketing authorisation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Virology
Rima Hajjo, Dima A. A. Sabbah, Osama H. H. Abusara, Reham Kharmah, Sanaa Bardaweel
Summary: Despite advances in fighting viral diseases, new therapies are still lacking and existing antivirals have limitations. Host-targeted antivirals (HTAs) are emerging as promising alternatives to directly acting antiviral (DAA) drugs. HTAs target host proteins and have a broader spectrum and lower potential for resistance.
Editorial Material
Medicine, General & Internal
Abi Rimmer
Summary: After going through a challenging period, some doctors now have the opportunity to reassess their career options and consider next steps that might be useful.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Editorial Material
Microbiology
Katrina L. Kalantar, Charles R. Langelier
Summary: Host/microbe metagenomics (mNGS) allows for simultaneous assessment of the dynamic relationship involving pathogen, host immune response, and microbiome, holding promise for new mechanistic insights and diagnostic approaches in treating infectious and inflammatory diseases.
Review
Chemistry, Medicinal
Xinchen Lu, Jinmei Jin, Ye Wu, Xiaoxia Liu, Xiaohui Liang, Jiayi Lin, Qingyan Sun, Jiangjiang Qin, Weidong Zhang, Xin Luan
Summary: This review discusses the critical role of RAS gene mutations in fatal cancers and explores the potential of PROTAC strategy as a powerful tool for handling undruggable targets. PROTAC is expected to become a feasible strategy to overcome the bottleneck of classical RAS inhibitors.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Immunology
Xiaorong Huang, Chumin Liang, Manman Li, Huimin Chen, Zhaowan Li, Qianqian Ruan, Ximing Hu, Lilian Zeng, Huifang Lin, Wei Zhao, Jianpeng Xiao, Limei Sun, Jiufeng Sun
Summary: Mass immunization programs have been successful in controlling SARS-CoV-2, but new VOCs pose challenges as they can evade vaccine-induced immunity and increase the risk of reinfection.
Article
Biochemistry & Molecular Biology
Sharon L. Freshour, Susanna Kiwala, Kelsy C. Cotto, Adam C. Coffman, Joshua F. McMichael, Jonathan J. Song, Malachi Griffith, Obi L. Griffith, Alex H. Wagner
Summary: The Drug-Gene Interaction Database (DGIdb) is a web resource that provides information on drug-gene interactions and druggable genes. DGIdb 4.0 is the latest major version release, featuring integration with crowdsourced efforts, addition of new sources, and updates to the data.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Engineering, Electrical & Electronic
Xin Wang, Haichao Li
Summary: This paper discusses the refocus process of moving targets in bistatic synthetic aperture radar (SAR) imagery obtained by the polar format algorithm (PFA). An analytical expression for the motion phase error in the two-dimensional frequency domain is deduced using the method of series reversion. A dictionary is formulated using the derived phase error equation, and a sparse-based iteration processing combined with a subtraction operation is proposed to separate clutter and refocus multiple moving targets. Finally, a numerical simulation is performed to validate the proposed method.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2022)
Article
Environmental Studies
Yingmiao Qian, Xian-an Yu, Xueli Chen, Malin Song
Summary: This paper constructs multiple incentive decision models based on contract theory to analyze developers' decision-making behaviors for incentivizing contractors' green technology innovation (GTI). It explores the impacts of greenness preference and service quality preference on contract prices, sales prices, innovation levels, and marketing effort levels. The results show the positive impacts of greenness preference and service quality preference on developers' and contractors' decisions and profits.
ENERGY & ENVIRONMENT
(2023)
Article
Mathematics
Ayesha Kalhoro, Asif Ali Wagan, Abdullah Ayub Khan, Jim-Min Lin, Chin Soon Ku, Lip Yee Por, Jing Yang
Summary: Non-fungible tokens (NFTs) are individual tokens containing valuable information stored on the blockchain, which can be bought and sold based on market demand. NFTs' unique data allows for easy verification and authentication of ownership and token transfer. This paper presents an NFT approach and business policies specific to the IT domain, discussing how NFT tokens can store software applications and provide rewards for developers.
Article
Computer Science, Software Engineering
Zohreh Sharafi, Ian Bertram, Michael Flanagan, Westley Weimer
Summary: This study aims to understand the code navigation strategies used by developers and the mechanisms they employ to find relevant information, and it found that developers' strategies evolve over time. A novel experimental design was proposed, and an eye-tracking study was conducted to dynamically identify relevant code areas. The results revealed a correlation between thrashing, a navigation activity, and lower effectiveness, and a three-phase model was proposed to characterize developers' navigation behavior.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2022)
Article
Computer Science, Software Engineering
Dror G. Feitelson, Ayelet Mizrahi, Nofar Noy, Aviad Ben Shabat, Or Eliyahu, Roy Sheffer
Summary: The names of variables and functions play a crucial role in program comprehension, but choosing good names is challenging. A series of experiments showed that the probability of two developers selecting the same name is low, but once a specific name is chosen, it is generally understood by most developers. Analysis of the experiment's names suggested a three-step model for naming: selecting concepts, choosing words for each concept, and constructing a name. Using this model improved the quality of names according to two independent judges.
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Farid A. Siddiqui, Vladimir Vukic, Tiina A. Salminen, Daniel Abankwa
Summary: Elaiophylin is a macrodiolide that disrupts the interaction between Hsp90 and Cdc37, selectively targeting K-Ras and inhibiting cancer stem cell properties. This mechanism is similar to conglobatin A and leads to decreased expression of Hsp90 client HIF1 alpha, resulting in potent effects on cancer cell formation.
