Insight into advances for the biosynthetic progress of fermented echinocandins of antifungals

Improving the production of the micafungin precursor FR901379 in an industrial production strain

(2023) Ping Men et al.   Microbial Cell Factories

Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1

(2023) Xinlin Hu et al.   NATURE

Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

(2022) Camille Marie Fortinez et al.   Nature Communications

Development of a FungalBraid Penicillium expansum ‐based expression system for the production of antifungal proteins in fungal biofactories

(2022) Mónica Gandía et al.   Microbial Biotechnology

Echinocandins – structure, mechanism of action and use in antifungal therapy

(2022) Mateusz Szymański et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Analysis of FR901379 Biosynthetic Genes in Coleophoma empetri by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

(2022) Teng-Yun Wei et al.   ACS Chemical Biology

Biosynthesis mechanism, genome mining and artificial construction of echinocandin O-sulfonation

(2022) Ping Men et al.   METABOLIC ENGINEERING

Engineering the biosynthesis of fungal nonribosomal peptides

(2022) Liwen Zhang et al.   NATURAL PRODUCT REPORTS

Phosphate limitation as crucial factor to enhance yeast lipid production from short‐chain fatty acids

(2022) Sergio Morales‐Palomo et al.   Microbial Biotechnology

Rezafungin: a novel antifungal for the treatment of invasive candidiasis

(2021) Young Yoon Ham et al.   Future Microbiology

Effects of Lipids and Surfactants on the Fermentation Production of Echinocandin B by Aspergillus nidulans

(2021) Kun Niu et al.   JOURNAL OF APPLIED MICROBIOLOGY

Glyap1 regulates pneumocandin B0 synthesis by controlling the intracellular redox balance in Glarea lozoyensis

(2021) Yan Dong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Establishing an Efficient Genetic Manipulation System for Sulfated Echinocandin Producing Fungus Coleophoma empetri

(2021) Ping Men et al.   Frontiers in Microbiology

Mutagenesis of echinocandin B overproducing Aspergillus nidulans capable of using starch as main carbon source

(2020) Zhong-Ce Hu et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Effects of methyl oleate and microparticle-enhanced cultivation on echinocandin B fermentation titer

(2020) Kun Niu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

CRISPR/Cas9-Based Genome Editing in the Filamentous Fungus Glarea lozoyensis and Its Application in Manipulating gloF

(2020) Teng-Yun Wei et al.   ACS Synthetic Biology

Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data

(2020) Yanan Zhao et al.   Journal of Fungi

Echinocandins: structural diversity, biosynthesis, and development of antimycotics

(2020) Wolfgang Hüttel   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Functional characterization of host toxic EcdB transcription factor protein of echinocandin B biosynthetic gene cluster

(2019) Arvind Kumar et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

(2019) Lydia L. Benitez et al.   DRUGS

Disruption of stcA blocks sterigmatocystin biosynthesis and improves echinocandin B production in Aspergillus delacroxii

(2019) Taoling Min et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Apc.LaeA and Apc.VeA of the velvet complex govern secondary metabolism and morphological development in the echinocandin-producing fungus Aspergillus pachycristatus

(2019) Nan Lan et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis

(2018) Feng Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antifungal drug resistance: evolution, mechanisms and impact

(2018) Nicole M Revie et al.   CURRENT OPINION IN MICROBIOLOGY

Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy

(2018) Amelia K. Sofjan et al.   Journal of Global Antimicrobial Resistance

Cryptic Production of trans -3-Hydroxyproline in Echinocandin B Biosynthesis

(2018) Johanna Mattay et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of pneumocandin lipopeptides and perspectives for its production and related echinocandins

(2018) Yan Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of Cotton Seed Powder as the Seed Medium Nitrogen Source on the Morphology and Pneumocandin B0 Yield of Glarea lozoyensis

(2018) Ping Song et al.   Frontiers in Microbiology

Structural elucidation of transmembrane domain zero (TMD0) of EcdL: A multidrug resistance-associated protein (MRP) family of ATP-binding cassette transporter protein revealed by atomistic simulation

(2017) Krishnendu Bera et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Enhanced production of natural yellow pigments from Monascus purpureus by liquid culture: The relationship between fermentation conditions and mycelial morphology

(2017) Jun Lv et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity

(2016) Li Chen et al.   ACS Chemical Biology

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

(2016) Voon Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-Activity Relationships of a Series of Echinocandins and the Discovery of CD101, a Highly Stable and Soluble Echinocandin with Distinctive Pharmacokinetic Properties

(2016) Kenneth D. James et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhancement of Echinocandin B Production by a UV- and Microwave-Induced Mutant of Aspergillus nidulans with Precursor- and Biotin-Supplying Strategy

(2016) Zhong-Ce Hu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Protoplast mutant selection ofGlarea Lozoyensisand statistical optimization of medium for pneumocandin B0yield-up

(2016) Tingting Qin et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster

(2016) Wolfgang Hüttel et al.   BMC GENOMICS

CD101: a novel long-acting echinocandin

(2016) Yanan Zhao et al.   CELLULAR MICROBIOLOGY

CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility

(2016) B Radha Krishnan et al.   JOURNAL OF ANTIBIOTICS

Genetic Manipulation of the Pneumocandin Biosynthetic Pathway for Generation of Analogues and Evaluation of Their Antifungal Activity

(2015) Yan Li et al.   ACS Chemical Biology

Mutagenesis breeding of high echinocandin B producing strain and further titer improvement with culture medium optimization

(2015) Shu-Ping Zou et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Engineering of Glarea lozoyensis for Exclusive Production of the Pneumocandin B0Precursor of the Antifungal Drug Caspofungin Acetate

(2014) Li Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pneumocandin Biosynthesis: Involvement of atrans-Selective Proline Hydroxylase

(2014) Stefanie Houwaart et al.   CHEMBIOCHEM

Echinocandins: production and applications

(2013) Tamás Emri et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

(2013) Li Chen et al.   BMC GENOMICS

EcdGHK Are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold

(2013) Wei Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)—A case study

(2013) James M. Balkovec et al.   NATURAL PRODUCT REPORTS

Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440

(2012) Ralph A. Cacho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps

(2011) Junying Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyphasic characterization of “Aspergillus nidulans var. roseus” ATCC 58397

(2011) Viktória Tóth et al.   FOLIA MICROBIOLOGICA

Micafungin: a sulfated echinocandin

(2009) Seiji Hashimoto   JOURNAL OF ANTIBIOTICS

Improvement of FR901379 production by mutant selection and medium optimization

(2009) Munekazu Kanda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Scale-up fermentation of echinocandin type antibiotic FR901379

(2009) Munekazu Kanda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379

(2008) Masaki Tomishima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin

(2008) Masaki Tomishima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS