Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis in vitro and in vivo

Diagnosis and Management of Multiple Myeloma

(2022) Andrew J. Cowan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?

(2021) Gilberto Gastelum et al.   Frontiers in Oncology

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

(2018) Srishti Singh et al.   MOLECULES

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

(2018) Claudiu T. Supuran   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

(2017) Gilberto Gastelum et al.   PLoS One

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

(2016) V. S. Mysore et al.   MOLECULAR CANCER RESEARCH

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma

(2015) P. Maiso et al.   CANCER RESEARCH

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

(2014) Stefano Fais et al.   CANCER AND METASTASIS REVIEWS

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Mammalian Target of Rapamycin Inhibitors Induce Tumor Cell ApoptosisIn VivoPrimarily by Inhibiting VEGF Expression and Angiogenesis

(2013) Patrick Frost et al.   Journal of Oncology

Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models

(2012) J. Hu et al.   Disease Models & Mechanisms

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

(2011) S K Martin et al.   LEUKEMIA

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events

(2009) S. Lehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA