Nanotechnologies meeting natural sources: Engineered lipoproteins for precise brain disease theranostics

Bio-fabricated nanodrugs with chemo-immunotherapy to inhibit glioma proliferation and recurrence

(2023) Ruoning Wang et al.   JOURNAL OF CONTROLLED RELEASE

Targeted liposomes for combined delivery of artesunate and temozolomide to resistant glioblastoma

(2022) Muhammad Ismail et al.   BIOMATERIALS

Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer’s Disease Therapy

(2022) Huaqing Zhang et al.   NANO LETTERS

Degradable Magnetic Nanoplatform with Hydroxide Ions Triggered Photoacoustic, MR Imaging, and Photothermal Conversion for Precise Cancer Theranostic

(2022) Yudan Yang et al.   NANO LETTERS

Recombinant High-Density Lipoprotein Boosts the Therapeutic Efficacy of Mild Hypothermia in Traumatic Brain Injury

(2022) Jialin Huang et al.   ACS Applied Materials & Interfaces

ApoE-mediated systemic nanodelivery of granzyme B and CpG for enhanced glioma immunotherapy

(2022) Jingjing Wei et al.   JOURNAL OF CONTROLLED RELEASE

New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

(2022) Yuyu Zhu et al.   Acta Pharmaceutica Sinica B

Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy

(2022) Hyemin Ju et al.   Asian Journal of Pharmaceutical Sciences

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

(2021) Wei Xiao et al.   BIOMATERIALS

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Adipose‐Derived Biogenic Nanoparticles for Suppression of Inflammation

(2020) Ming Tian et al.   Small

Tailored Reconstituted Lipoprotein for Site-Specific and Mitochondria-Targeted Cyclosporine A Delivery to Treat Traumatic Brain Injury

(2020) Lepei Chen et al.   ACS Nano

Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis

(2020) Lisen Lu et al.   BIOMATERIALS

ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice

(2020) Qiyue Wang et al.   JOURNAL OF CONTROLLED RELEASE

Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma

(2020) Jinhwan Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

(2020) Wei-Na Jin et al.   NATURE NEUROSCIENCE

Reassembly of native components with donepezil to execute dual-missions in Alzheimer's disease therapy

(2019) Huaqing Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders

(2019) Elizabeth S. Smith et al.   ADVANCED DRUG DELIVERY REVIEWS

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

(2019) Karol Kaiser et al.   Nature Communications

Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier

(2019) Synnøve Nymark Aasen et al.   MOLECULAR CANCER THERAPEUTICS

Laser-triggered polymeric lipoproteins for precision tumor penetrating theranostics

(2019) Ruoning Wang et al.   BIOMATERIALS

Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis

(2019) Craig Ramirez et al.   NATURE

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery

(2018) Xinyi Ma et al.   Acta Pharmaceutica Sinica B

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

(2018) Yu Jiang et al.   ACS Nano

Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

(2018) Xiaoqian Niu et al.   Asian Journal of Pharmaceutical Sciences

Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma

(2017) Rui Kuai et al.   International Journal of Nanomedicine

Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma

(2017) M. A. Rajora et al.   Chemical Science

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles

(2016) Kaylin M. McMahon et al.   ADVANCED FUNCTIONAL MATERIALS

Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery

(2016) Ruoning Wang et al.   JOURNAL OF CONTROLLED RELEASE

Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood–Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery

(2016) Qingxiang Song et al.   MOLECULAR PHARMACEUTICS

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

(2016) Jun Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer’s Disease

(2015) Meng Huang et al.   ACS Nano

Lipoprotein-Based Nanoparticles Rescue the Memory Loss of Mice with Alzheimer’s Disease by Accelerating the Clearance of Amyloid-Beta

(2014) Qingxiang Song et al.   ACS Nano

Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes

(2014) Donatella Paolino et al.   BIOMATERIALS

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles

(2012) Tomoko Nakayama et al.   MOLECULAR THERAPY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16Å Resolution at Physiological Body Temperature

(2011) Vibhor Kumar et al.   PLoS One

Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel

(2009) Walter J. McConathy et al.   ANTI-CANCER DRUGS