Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review

(2022) Liang Zhao et al.   Theranostics

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

(2022) Nathan E. Reticker-Flynn et al.   CELL

Single‐cell RNA ‐seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer

(2022) Yan Qian et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting metastatic cancer

(2021) Karuna Ganesh et al.   NATURE MEDICINE

Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq

(2021) Bin Wang et al.   Scientific Reports

Diagnosis and Treatment of Metastatic Colorectal Cancer

(2021) Leah H. Biller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lymphatic metastasis of bladder cancer: Molecular mechanisms, diagnosis and targeted therapy

(2021) Sen Liu et al.   CANCER LETTERS

Targeting FAPα-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis

(2021) Xiaobo Li et al.   CANCER LETTERS

The pre-metastatic niche in lymph nodes: formation and characteristics

(2021) Lionel Gillot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Applications of single-cell sequencing in cancer research: progress and perspectives

(2021) Yalan Lei et al.   Journal of Hematology & Oncology

Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis

(2021) Ziming Yuan et al.   Cell Death & Disease

The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

(2021) Geni Ye et al.   Acta Pharmaceutica Sinica B

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

(2021) Kun Xu et al.   Oncogenesis

Mapping the spreading routes of lymphatic metastases in human colorectal cancer

(2020) Chong Zhang et al.   Nature Communications

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Recent advances in drug delivery systems for targeting cancer stem cells

(2020) Hongxia Duan et al.   Acta Pharmaceutica Sinica B

Lymph‐circulating tumor cells show distinct properties to blood‐circulating tumor cells and are efficient metastatic precursors

(2019) Sulma I. Mohammed et al.   Molecular Oncology

Mutations of key driver genes in colorectal cancer progression and metastasis

(2018) Dongdong Huang et al.   CANCER AND METASTASIS REVIEWS

Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

(2018) Ellen Puré et al.   ONCOGENE

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

(2018) Ethel R. Pereira et al.   SCIENCE

Growth and Immune Evasion of Lymph Node Metastasis

(2018) Dennis Jones et al.   Frontiers in Oncology

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Fibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?

(2017) Lucienne Juillerat-Jeanneret et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents

(2017) Minfeng Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system

(2017) Mikael C. Karlsson et al.   Molecular Oncology

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

(2016) Anna Mazur et al.   PLoS One

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

The lymph node microenvironment and its role in the progression of metastatic cancer

(2015) Ethel R. Pereira et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sentinel lymph node metastases in cancer: Causes, detection and their role in disease progression

(2015) S.D. Nathanson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanical and structural comparison between primary tumor and lymph node metastasis cells in colorectal cancer

(2015) V. Palmieri et al.   Soft Matter

Mechanisms of lymphatic metastasis

(2014) Sinem Karaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma

(2014) H Wang et al.   Cell Death & Disease

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

(2013) Suvendu Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Evaluation of the tumor targeting of a FAPα-based doxorubicin prodrug

(2011) Sichao Huang et al.   JOURNAL OF DRUG TARGETING

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma

(2009) Daniel Royston et al.   JOURNAL OF PATHOLOGY