Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis

A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors

(2022) Diyuan Xue et al.   Science Immunology

Peritoneal Metastases from Extraperitoneal Primary Tumors: Incidence, Treatment, and Survival from a Nationwide Database

(2022) Anouk Rijken et al.   Indian Journal of Surgical Oncology

Novel strategies exploiting interleukin-12 in cancer immunotherapy

(2022) Assunta Cirella et al.   PHARMACOLOGY & THERAPEUTICS

cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory

(2022) David A. Christian et al.   Science Immunology

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

(2021) Giulia Agliardi et al.   Nature Communications

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory

(2021) Maria Hinterberger et al.   Journal for ImmunoTherapy of Cancer

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

(2021) Ignacio Melero et al.   Nature Reviews Clinical Oncology

The Essential Involvement of the Omentum in the Peritoneal Defensive Mechanisms During Intra-Abdominal Sepsis

(2021) Ying Liu et al.   Frontiers in Immunology

Peritoneal Metastases From Colorectal Cancer: Defining and Addressing the Challenges

(2021) Onno Kranenburg et al.   Frontiers in Oncology

Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors

(2021) Shirley Tenesaca et al.   Journal for ImmunoTherapy of Cancer

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

(2020) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment

(2020) Susannah L Hewitt et al.   CLINICAL CANCER RESEARCH

Specialized immune responses in the peritoneal cavity and omentum

(2020) Mingyong Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1

(2020) Venkatesh Krishnan et al.   Communications Biology

Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics

(2019) Zong Sheng Guo et al.   Journal for ImmunoTherapy of Cancer

Development of an Interleukin-12 Fusion Protein That Is Activated by Cleavage with Matrix Metalloproteinase 9

(2019) Denise Skrombolas et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

4PNovel applications of MVA to improve outcomes in immunooncology

(2019) C Heery et al.   ANNALS OF ONCOLOGY

Peritoneal carcinomatosis index predicts survival in colorectal patients undergoing HIPEC using oxaliplatin: a retrospective single-arm cohort study

(2019) Atuhani Burnett et al.   World Journal of Surgical Oncology

Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox

(2019) Phillip R. Pittman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies

(2019) José Medina-Echeverz et al.   Nature Communications

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

(2019) Iñaki Etxeberria et al.   CANCER CELL

Phase I study of oncolytic vaccinia virus GL-ONC1 in patients with peritoneal carcinomatosis

(2018) Ulrich M. Lauer et al.   CLINICAL CANCER RESEARCH

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

(2018) Pedro Berraondo et al.   CLINICAL CANCER RESEARCH

Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells

(2018) Keunok Jung et al.   OncoImmunology

In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma

(2018) Matthew J. Frank et al.   Cancer Discovery

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

(2018) WonJae Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review

(2017) Juliette O. A. M. van Baal et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA + Metastatic Colorectal Cancers

(2017) Chengcheng Zhang et al.   MOLECULAR THERAPY

Immunological Functions of the Omentum

(2017) Selene Meza-Perez et al.   TRENDS IN IMMUNOLOGY

Intraperitoneal immunotherapy: historical perspectives and modern therapy

(2016) W F Morano et al.   CANCER GENE THERAPY

Complications after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis: Risk factors for ICU admission and morbidity prognostic score

(2016) Sylvain Malfroy et al.   SURGICAL ONCOLOGY-OXFORD

A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

(2015) Mythili Koneru et al.   Journal of Translational Medicine

Peritoneal carcinomatosis of gastrointestinal tumors: Where are we now?

(2014) Cem Terzi   WORLD JOURNAL OF GASTROENTEROLOGY

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

(2014) Peihong Dai et al.   PLoS Pathogens

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Peritoneal carcinomatosis

(2013) Federico Coccolini   WORLD JOURNAL OF GASTROENTEROLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Lymphoid Organs for Peritoneal Cavity Immune Response: Milky Spots

(2009) Reina E. Mebius   IMMUNITY

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

(2009) Javier Rangel-Moreno et al.   IMMUNITY