Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway

Prognostic Impact of High Baseline Stromal Tumor-Infiltrating Lymphocytes in the Absence of Pathologic Complete Response in Early-Stage Triple-Negative Breast Cancer

(2022) Nour Abuhadra et al.   Cancers

Baseline predictors of hematological toxicity in patients with advanced cancer treated with ATR inhibitors in phase I/II clinical trials.

(2022) Natalie Ngoi et al.   JOURNAL OF CLINICAL ONCOLOGY

Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling

(2022) Ahmed Emam et al.   NATURE CELL BIOLOGY

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer

(2022) Jing Zhang et al.   Biomedicines

High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types

(2021) D.J. McGrail et al.   ANNALS OF ONCOLOGY

IFNγ signaling integrity in colorectal cancer immunity and immunotherapy

(2021) Wan Du et al.   Cellular & Molecular Immunology

A Tale of Two Checkpoints: ATR Inhibition and PD-(L)1 Blockade

(2021) Natalie Y.L. Ngoi et al.   Annual Review of Medicine

Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers

(2021) Daniel J. McGrail et al.   Science Translational Medicine

765 The first-in-class small molecule TREX1 inhibitor CPI-381 demonstrates type I IFN induction and sensitization of tumors to immune checkpoint blockade

(2021) Costa Salojin et al.   Journal for ImmunoTherapy of Cancer

ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma

(2020) Hailong Sheng et al.   Journal for ImmunoTherapy of Cancer

Role of DNA repair defects in predicting immunotherapy response

(2020) Jing Zhang et al.   Biomarker Research

First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors

(2020) Timothy A. Yap et al.   Cancer Discovery

Reality CHEK: Understanding the biology and clinical potential of CHK1

(2020) Fiifi Neizer-Ashun et al.   CANCER LETTERS

A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes

(2019) Jing Zhang et al.   NUCLEIC ACIDS RESEARCH

HumCFS: a database of fragile sites in human chromosomes

(2019) Rajesh Kumar et al.   BMC GENOMICS

Phase 1, open-label, dose-escalation study of M3814 + avelumab ± radiotherapy (RT) in patients (pts) with advanced solid tumors.

(2019) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Open-label, multicenter, phase I study to assess safety and tolerability of adavosertib plus durvalumab in patients with advanced solid tumors.

(2019) Manish R. Patel et al.   JOURNAL OF CLINICAL ONCOLOGY

Current Landscape of Immunotherapy in Breast Cancer

(2019) Sylvia Adams et al.   JAMA Oncology

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

(2019) Ming-Ming Hu et al.   Annual Review of Immunology

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers

(2018) Daniel J. McGrail et al.   Nature Communications

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

(2017) Erkin Erdal et al.   GENES & DEVELOPMENT

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection

(2016) Brian D. Lehmann et al.   PLoS One

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

(2014) R. Salgado et al.   ANNALS OF ONCOLOGY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

NF- B Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells

(2012) R. Muthuswamy et al.   CANCER RESEARCH

Tumoral Lymphocytic Infiltration and Expression of the Chemokine CXCL10 in Breast Cancers from the Ontario Familial Breast Cancer Registry

(2012) A. M. Mulligan et al.   CLINICAL CANCER RESEARCH

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL