4.6 Article

Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats

Journal

PROBIOTICS AND ANTIMICROBIAL PROTEINS
Volume -, Issue -, Pages -

Publisher

SPRINGER
DOI: 10.1007/s12602-023-10173-4

Keywords

Probiotics cheese; Lactobacillus acidophilus La-05; Chronic kidney disease; Oxidative stress; Inflammation; Cardiac hypertrophy

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This study evaluated the effect of probiotic-enriched Minas cheese on cardiac, inflammatory, and oxidative stress parameters in an experimental rat model of chronic kidney disease. The results suggest that probiotic-enriched Minas cheese may have a cardioprotective effect and can downregulate SOD activity in a rat model of CKD.
Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (10(8)-10(9) log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 +/- 0.85 vs. 19.05 +/- 0.56 mu m, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 +/- 49.12 vs. 599.4 +/- 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.

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