Article
Biotechnology & Applied Microbiology
Xi-Yuan Cao, Reyihanguli Aimaier, Jun Yang, Jing Yang, Zhong-Yi Chen, Jing-Jing Zhao, Li Yin, Qi Zhang, Jia You, Hui Zhang, Hao-Ran Li, Jia-Yi Chen, Qing-Chen Mao, Li-Ping Yang, Fei Yu, He-Ping Zhao, Hui-Xin Zhao
Summary: It has been found that the secondary metabolites of Bacillus subtilis strain Z15 can enhance immune function in mice, showing potential in treating fungal infections. Blood transcriptome analysis revealed the molecular mechanism and immune-related pathways involved. These findings provide a theoretical foundation for the development and application of immunotherapeutic approaches.
Article
Biotechnology & Applied Microbiology
Yu Sun, Wen-Cai Liu, Xuan Shi, Hai-Zhou Zheng, Zhi-Hui Zheng, Xin-Hua Lu, Yan Xing, Kai Ji, Mei Liu, Yue-Sheng Dong
Summary: The co-culture strategy can induce the biosynthesis of novel metabolites, leading to global changes in the metabolite profile. A new method integrating computational programs and web-based tools has been developed to efficiently and accurately analyze and identify metabolites of co-culture, offering an effective approach to study novel compounds in co-culture systems.
MICROBIAL CELL FACTORIES
(2021)
Article
Microbiology
Zhong-Yi Chen, Xieerwanimu Abuduaini, Nuramina Mamat, Qi-Lin Yang, Meng-Jun Wu, Xin-Rui Lin, Ru Wang, Rong-Rong Lin, Wei-Jun Zeng, Huan-Chen Ning, He-Ping Zhao, Jin-Yu Li, Hui-Xin Zhao
Summary: The study demonstrates the antagonistic activity of BS-Z15 against Verticillium dahliae. The genome of BS-Z15 contains genes related to various antagonistic mechanisms, which are closely related to Bacillus group members.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Hai-Yue Lan, Pei An, Qiu-Ping Liu, Yu-Ying Chen, Yuan-Yuan Yu, Xin Luan, Jian-Yuan Tang, Hong Zhang
Summary: Aidi injection inhibits the growth of liver cancer by regulating the PI3K/Akt and MAPK signal transduction pathways, inducing mitochondrial apoptosis pathway through MMP collapse, and ultimately eliciting apoptosis of hepatocellular carcinoma cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Mathematics, Applied
Jianyu Hu, Xiaoli Chen, Jinqiao Duan
Summary: We investigate the quantitative network of gene expression dynamics in the competence development of Bacillus subtilis, quantifying the most probable transition pathways for both excitable and bistable dynamics and analyzing how noise intensity affects the transition phenomena.
Article
Chemistry, Medicinal
Malvi Surti, Mitesh Patel, Alya Redhwan, Lamya Ahmed Al-Keridis, Mohd Adnan, Nawaf Alshammari, Mandadi Narsimha Reddy
Summary: This study investigated the mechanism of action of IQ on HCT-116 cells. The results demonstrate that IQ significantly suppresses cell viability in a dose-dependent manner and triggers apoptosis through the mitochondrial-mediated pathway.
Article
Marine & Freshwater Biology
Jiawen Cui, Yuhao Liu, Zhiyu Hao, Yuhang Liu, Minna Qiu, Lu Kang, Xiaohua Teng, You Tang
Summary: In this experiment, a poisoning model of common carp with cadmium (Cd) exposure was established to assess the nephrotoxicity of Cd. Results showed that Cd exposure induced kidney injury and had an impact on mitochondrial damage and apoptosis. This study provides insights into the underlying mechanisms and theoretical basis for evaluating Cd toxicity to aquatic organisms.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaokang Wu, Yang Li, Ke Jin, Linpei Zhang, Jianghua Li, Yanfeng Liu, Guocheng Du, Xueqin Lv, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu
Summary: In this study, a 'design-build-test-learn' framework was used to achieve efficient multiplexed optimization of metabolic pathways in Bacillus subtilis. By constructing a platform strain with biosensor signal-amplifying circuits and genetic regulation circuits, and integrating a synthetic CRISPR RNA array blend (ScrABBLE) device, 5,184 combinatorial assemblies targeting three genes were generated. The best GlcN6P producer was screened and engineered for the synthesis of valuable pharmaceuticals, with a N-acetylglucosamine titer of 183.9 g liter(-1) achieved in a 15-liter bioreactor. The potential generic application of the ScrABBLE device was also verified using three fluorescent proteins as a case study.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Oncology
Lin Che, Jia-Shen Wu, Ze-Bang Du, Yu-Qiao He, Lei Yang, Jin-Xian Lin, Zhao Lei, Xiao-Xuan Chen, Dong-Bei Guo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Summary: Translation: New therapeutic strategies are needed to improve the anti-cancer effect for hepatocellular carcinoma (HCC). This study explores the involvement of mitochondrial translocation of cyclooxygenase-2 (COX-2) in mitochondrial dynamics and sensitization of HCC cells to anti-tumor therapy. The findings suggest that targeting mitochondrial COX-2 could be a potential therapeutic approach for HCC and other cancers with high expression of COX-2.
Article
Chemistry, Multidisciplinary
Shinji Kishimoto, Ayumi Minami, Yoshimitsu Aoki, Yuya Matsubara, Shogo Watanabe, Kenji Watanabe
Summary: Pathogenic fungi of Aspergillus section Fumigati are capable of producing various secondary metabolites. This study reports the isolation of fumimycin and a new compound named lentofuranine from A. lentulus. These compounds were found to be assembled through a nonenzymatic condensation involving a polyketide intermediate from the terrein biosynthetic pathway and a highly reactive azlactone intermediate. The formation of an unusual carbon skeleton is attributed to the reactivity of azlactone.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Plant Sciences
Li-Juan Deng, Yu-He Lei, Jing-Yu Quan, Bao-Jing Li, Dong-Mei Zhang, Hai-Yan Tian, Ye Chen, En-Xin Zhang, Lei Chen, Wen-Cai Ye, Wei-Min Ning, Lin-Zhong Yu, Jun-Shan Liu
Summary: This study evaluated the anti-hepatoma activity of 1 beta-OH-ABF against liver cancer cells in vitro and in vivo, and explored the underlying mechanisms. Results showed that 1 beta-OH-ABF induces mitochondrial apoptosis through the suppression of mTOR signaling in vitro and in vivo, suggesting its potential as a treatment for liver cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao
Summary: Toosendanin (TSN) extracted from Melia toosendan Sieb et Zucc has been demonstrated to possess antitumor activities on ovarian cancer cells, inhibiting cell proliferation, inducing apoptosis, reducing mitochondrial membrane potential, and suppressing invasion and migration. TSN's effects are associated with modulation of expression levels of key proteins related to the caspase-dependent mitochondrial apoptotic pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Horticulture
Yao Ma, Siwen Zhang, Jiawei Hu, Shiyong Chen, Juanjuan Wang
Summary: With excessive use of nitrogen fertilizer, the accumulation of nitrate in soil and vegetables has become a serious problem. This study found that the combination of Bacillus subtilis Strain11 and Molybdenum can effectively promote the growth of Chinese cabbage and reduce soil nitrate content.