PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells

Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

(2022) Kristin S. Inman et al.   Cancers

Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer

(2022) Jashodeep Datta et al.   GASTROENTEROLOGY

The JAK-STAT pathway at 30: Much learned, much more to do

(2022) Rachael L. Philips et al.   CELL

STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer

(2022) Xin Li et al.   Biomolecules

Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer

(2022) Takahito Kawano et al.   Cancers

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

(2021) Huang Chen et al.   ONCOGENE

Therapeutic targeting of STAT3 pathways in pancreatic adenocarcinoma: A systematic review of clinical and preclinical literature

(2021) Sarah Peisl et al.   PLoS One

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions

(2021) Annachiara Tesoriere et al.   Biomedicines

PKCι regulates the expression of PDL1 through multiple pathways to modulate immune suppression of pancreatic cancer cells

(2021) Hongmei Zhang et al.   CELLULAR SIGNALLING

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer

(2021) Sultan Alhayyani et al.   ONCOGENE

Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer

(2020) Austin R. Dosch et al.   MOLECULAR CANCER RESEARCH

Mu-KRAS attenuates Hippo signaling pathway through PKCι to sustain the growth of pancreatic cancer

(2019) Peipei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

(2019) Jesse Balic et al.   CANCER RESEARCH

IL-22RA1/ STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer

(2018) Weizhi He et al.   CANCER RESEARCH

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

STAT3: a multifaceted oncoprotein

(2018) Aleks C. Guanizo et al.   GROWTH FACTORS

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

(2018) Nagaraj S Nagathihalli et al.   CANCER RESEARCH

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis

(2018) Stephen D'Amico et al.   GENES & DEVELOPMENT

PKCι and YAP1 are crucial in promoting pancreatic tumorigenesis

(2018) Peipei Wang et al.   Oncotarget

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

(2017) Aleksandra Adamska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma

(2017) Nisebita Sahu et al.   MOLECULAR CANCER THERAPEUTICS

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

(2016) Ralph Gruber et al.   GASTROENTEROLOGY

Genetics and biology of pancreatic ductal adenocarcinoma

(2016) Haoqiang Ying et al.   GENES & DEVELOPMENT

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

(2015) Beatrice Grabner et al.   Nature Communications

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45

(2012) Ryohei Wakahara et al.   GENES TO CELLS

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Protein Kinase C  Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis

(2010) M. L. Scotti et al.   CANCER RESEARCH

Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma

(2009) S Takemoto et al.   BRITISH JOURNAL OF CANCER

Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex

(2009) J Moscat et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

(2008) Chun-Liang Chen et al.   Molecular Cancer