Journal
ORGANIC LETTERS
Volume 17, Issue 10, Pages 2330-2333Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00739
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Funding
- Ministry of Science and Technology [MOST103-2320-B-110-004]
- National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Projects [NSYSU-KMU 103-I005, 104-I001]
- Academia Summit Project [5202401023-2]
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Two novel meroterpenoids, yaminterritrems A (1) and B (2), were isolated from Aspergillus terreus collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 degrees C. The structures of 1 and 2 were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for 1 and 2 involving the conversion of the sesquiterpene with phenyl-alpha-pyrone is proposed. Besides, 2 exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages.
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