Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity

Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action

(2022) Sanjay Goel et al.   Frontiers in Genetics

MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells

(2021) Yancai Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention

(2021) Deepa Shah et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

(2021) Geni Ye et al.   Acta Pharmaceutica Sinica B

Reversal of P‑Glycoprotein-Mediated Multidrug Resistance by Novel Curcumin Analogues in Paclitaxel-resistant Human Breast Cancer Cells

(2020) Lei Gao et al.   Biochemistry and Cell Biology

Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells

(2020) Chao Liu et al.   Cancer Medicine

(−)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway

(2019) Xiaoqin La et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction

(2019) M.C. Asensio-Lopez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene

(2018) Gabriela Antonio-Andrés et al.   LEUKEMIA & LYMPHOMA

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism

(2018) Mingzhu Bai et al.   ONCOGENE

Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma

(2018) Xing Bao et al.   Cell Death & Disease

Long term treatment of metformin impedes development of chemoresistance by regulating cancer stem cell differentiation through taurine generation in ovarian cancer cells

(2018) Aniketh Bishnu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2

(2017) Depeng Shang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models

(2017) Ying Li et al.   Oncotarget

MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene

(2016) Youguang Pu et al.   Cancer Cell International

NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells

(2016) N H Abd Ellah et al.   CANCER GENE THERAPY

Metformin confers risk reduction for developing hepatocellular carcinoma recurrence after liver resection

(2016) Kun-Ming Chan et al.   LIVER INTERNATIONAL

Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer

(2015) Claire Greenhill   Nature Reviews Gastroenterology & Hepatology

Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling

(2015) Yuan-Zheng Xia et al.   PHYTOMEDICINE

Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells

(2014) SUNBIN LING et al.   Molecular Medicine Reports

YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma

(2011) Filomena de Nigris et al.   BMC CANCER

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

(2011) Ji-Won Jung et al.   PLoS One

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY