A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO)

An epigenetic signal encoded protection mechanism is activated by graphene oxide to inhibit its induced reproductive toxicity in Caenorhabditis elegans

(2016) Yunli Zhao et al.   BIOMATERIALS

Diameter size and aspect ratio as critical determinants of uptake, stress response, global metabolomics and epigenetic alterations in multi-wall carbon nanotubes

(2016) Nivedita Chatterjee et al.   CARBON

Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk

(2016) Pedro M. Costa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans

(2016) Yunli Zhao et al.   Scientific Reports

The short- and long-term effects of orally administered high-dose reduced graphene oxide nanosheets on mouse behaviors

(2015) Ding Zhang et al.   BIOMATERIALS

Long-term toxicity of reduced graphene oxide nanosheets: Effects on female mouse reproductive ability and offspring development

(2015) Shun Xu et al.   BIOMATERIALS

A systems toxicology approach on the mechanism of uptake and toxicity of MWCNT in Caenorhabditis elegans

(2015) Hyun-Jeong Eom et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gene delivery by a cationic and thermosensitive nanogel promoted established tumor growth inhibition

(2015) Peng Cao et al.   Nanomedicine

KEGG as a reference resource for gene and protein annotation

(2015) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The effects of graphene nanostructures on mesenchymal stem cells

(2014) Yahfi Talukdar et al.   BIOMATERIALS

A micro-sized model for the in vivo study of nanoparticle toxicity: what has Caenorhabditis elegans taught us?

(2014) Jinhee Choi et al.   Environmental Chemistry

Use of an Activated Beta-Catenin to Identify Wnt Pathway Target Genes in Caenorhabditis elegans , Including a Subset of Collagen Genes Expressed in Late Larval Development

(2014) Belinda M. Jackson et al.   G3-Genes Genomes Genetics

Biomedical Applications of Graphene and Graphene Oxide

(2013) Chul Chung et al.   ACCOUNTS OF CHEMICAL RESEARCH

Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages

(2013) Guangbo Qu et al.   ACS Nano

A dual role of the Wnt signaling pathway during aging inCaenorhabditis elegans

(2013) Marco Lezzerini et al.   AGING CELL

Graphene: Safe or Toxic? The Two Faces of the Medal

(2013) Alberto Bianco   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration

(2013) Kai Yang et al.   BIOMATERIALS

A systems toxicology approach to the surface functionality control of graphene–cell interactions

(2013) Nivedita Chatterjee et al.   BIOMATERIALS

Effects of silver nanoparticles on oxidative DNA damage-repair as a function of p38 MAPK status: A comparative approach using human Jurkat T cells and the nematodeCaenorhabditis elegans

(2013) Nivedita Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells

(2013) Anxin Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Contributions of altered permeability of intestinal barrier and defecation behavior to toxicity formation from graphene oxide in nematode Caenorhabditis elegans

(2013) Qiuli Wu et al.   Nanoscale

Multiple functions of the noncanonical Wnt pathway

(2013) Eva Gómez-Orte et al.   TRENDS IN GENETICS

Graphene: Powder, Flakes, Ribbons, and Sheets

(2012) Dustin K. James et al.   ACCOUNTS OF CHEMICAL RESEARCH

Safety Considerations for Graphene: Lessons Learnt from Carbon Nanotubes

(2012) Cyrill Bussy et al.   ACCOUNTS OF CHEMICAL RESEARCH

Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

(2012) Wendi Zhang et al.   ADVANCED MATERIALS

Size-dependent genotoxicity of graphene nanoplatelets in human stem cells

(2012) Omid Akhavan et al.   BIOMATERIALS

Cell specific cytotoxicity and uptake of graphene nanoribbons

(2012) Sayan Mullick Chowdhury et al.   BIOMATERIALS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Recent advances in graphene family materials toxicity investigations

(2012) Agnieszka Maria Jastrzębska et al.   JOURNAL OF NANOPARTICLE RESEARCH

Graphite Nanoplatelets and Caenorhabditis elegans: Insights from an in Vivo Model

(2012) Elena Zanni et al.   NANO LETTERS

A roadmap for graphene

(2012) K. S. Novoselov et al.   NATURE

Mechanism of Cellular Uptake of Graphene Oxide Studied by Surface-Enhanced Raman Spectroscopy

(2012) Jie Huang et al.   Small

Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts

(2011) Ken-Hsuan Liao et al.   ACS Applied Materials & Interfaces

Antibacterial Activity of Graphite, Graphite Oxide, Graphene Oxide, and Reduced Graphene Oxide: Membrane and Oxidative Stress

(2011) Shaobin Liu et al.   ACS Nano

Graphene-Based Nanoplatelets: A New Risk to the Respiratory System as a Consequence of Their Unusual Aerodynamic Properties

(2011) Anja Schinwald et al.   ACS Nano

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

(2011) Vanesa C. Sanchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans

(2011) Dongyoung Lim et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Graphene in biomedicine: opportunities and challenges

(2011) Liangzhu Feng et al.   Nanomedicine

Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene

(2011) Abhilash Sasidharan et al.   Nanoscale

Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria

(2010) Omid Akhavan et al.   ACS Nano

EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad

(2010) Andrea K. Kalis et al.   DEVELOPMENTAL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

(2008) Maxwell C. K. Leung et al.   TOXICOLOGICAL SCIENCES