Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae

Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against Acinetobacter baumannii: A Metabolomic Study

(2022) Maytham Hussein et al.   Pharmaceutics

Multiple Novel Ceftazidime-Avibactam-Resistant Variants of bla KPC-2 -Positive Klebsiella pneumoniae in Two Patients

(2022) Qingyu Shi et al.   Microbiology Spectrum

The primary pharmacology of ceftazidime/avibactam: in vivo translational biology and pharmacokinetics/pharmacodynamics (PK/PD)

(2022) Wright W. Nichols et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

(2021) Amit Pathania et al.   mBio

Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents

(2021) Giancarlo Casillas-Vargas et al.   PROGRESS IN LIPID RESEARCH

Ceftazidime/Avibactam-Resistant Klebsiella pneumoniae subsp. pneumoniae Isolates in a Tertiary Italian Hospital: Identification of a New Mutation of the Carbapenemase Type 3 (KPC-3) Gene Conferring Ceftazidime/Avibactam Resistance

(2021) Carla Fontana et al.   Microorganisms

Multitarget Approaches against Multiresistant Superbugs

(2020) Declan Alan Gray et al.   ACS Infectious Diseases

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study

(2020) Maytham Hussein et al.   mSystems

Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE

(2020) Cory T. Reidl et al.   Antibiotics-Basel

Nucleotide Sugars in Chemistry and Biology

(2020) Satu Mikkola   MOLECULES

Metabolic mechanism of ceftazidime resistance in Vibrio alginolyticus

(2019) Shi-Rao Liu et al.   Infection and Drug Resistance

Dose Selection and Validation for Ceftazidime-Avibactam in Adults with Complicated Intra-abdominal Infections, Complicated Urinary Tract Infections, and Nosocomial Pneumonia

(2019) Shampa Das et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

(2019) Kati Räisänen et al.   Eurosurveillance

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

(2019) Maytham Hussein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Systematic Approach to the Selection of the Appropriate Avibactam Concentration for Use with Ceftazidime in Broth Microdilution Susceptibility Testing

(2018) Patricia A. Bradford et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria

(2018) Yu-bin Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism

(2018) M. Boersch et al.   RSC Advances

Detection of novel mutations associated with independent and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates

(2018) Md Mahmudul Islam et al.   CLINICAL MICROBIOLOGY AND INFECTION

Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate

(2017) Irnov Irnov et al.   PLoS Genetics

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action

(2016) Isabel M. Vincent et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure, Function, and Inhibition ofStaphylococcus aureusHeptaprenyl Diphosphate Synthase

(2016) Janish Desai et al.   ChemMedChem

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

(2016) Ben C. Chung et al.   NATURE

Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity

(2015) Kirsten M. Schutte et al.   INFECTION AND IMMUNITY

The β-Lactams Strike Back: Ceftazidime-Avibactam

(2015) Evan J. Zasowski et al.   PHARMACOTHERAPY

Efficacy of a Ceftazidime-Avibactam Combination in a Murine Model of Septicemia Caused by Enterobacteriaceae Species Producing AmpC or Extended-Spectrum β-Lactamases

(2014) Premavathy Levasseur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tigecycline resistance in Acinetobacter baumannii mediated by frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase

(2014) X. Li et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Multistate Point-Prevalence Survey of Health Care–Associated Infections

(2014) Shelley S. Magill et al.   NEW ENGLAND JOURNAL OF MEDICINE

A comparison of methods for differential expression analysis of RNA-seq data

(2013) Charlotte Soneson et al.   BMC BIOINFORMATICS

A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During  -Lactam Stress

(2013) V. Chittezham Thomas et al.   mBio

Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine

(2012) Tong Zhang et al.   ANALYTICAL CHEMISTRY

Phosphatidic acid synthesis in bacteria

(2012) Jiangwei Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target

(2012) Danuta M. Gillner et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

Carbapenem Resistance in Klebsiella pneumoniae Due to the New Delhi Metallo- -lactamase

(2011) H. Sidjabat et al.   CLINICAL INFECTIOUS DISEASES

Transpeptidase-Mediated Incorporation ofd-Amino Acids into Bacterial Peptidoglycan

(2011) Tania J. Lupoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emergence of Klebsiella pneumoniae Carbapenemase-Producing Bacteria

(2011) Ryan S. Arnold et al.   SOUTHERN MEDICAL JOURNAL

Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides

(2009) Shin-ichiro Narita et al.   FEBS LETTERS

Attributable Mortality Rate for Carbapenem-Resistant Klebsiella pneumoniae Bacteremia

(2009) Abraham Borer et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Membrane lipid homeostasis in bacteria

(2008) Yong-Mei Zhang et al.   NATURE REVIEWS MICROBIOLOGY