The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5

Transcription factor protein interactomes reveal genetic determinants in heart disease

(2022) Barbara Gonzalez-Teran et al.   CELL

Base-resolution models of transcription-factor binding reveal soft motif syntax

(2021) Žiga Avsec et al.   NATURE GENETICS

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

(2021) Jonathan Li et al.   iScience

A New ISL1 Loss-of-Function Mutation Predisposes to Congenital Double Outlet Right Ventricle

(2019) Zhi Wang et al.   International Heart Journal

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers

(2019) Brynn N. Akerberg et al.   Nature Communications

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

(2018) David J. Anderson et al.   Nature Communications

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

(2018) Roberto Quaranta et al.   eLife

ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells

(2016) Yang Wang et al.   NUCLEIC ACIDS RESEARCH

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

(2016) Judd F. Hultquist et al.   Cell Reports

The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

(2015) Luca Caputo et al.   Cell Stem Cell

Transcription factor ISL1 is essential for pacemaker development and function

(2015) Xingqun Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex

(2015) So Yeon Seo et al.   MOLECULAR AND CELLULAR BIOLOGY

SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes

(2015) Jamie R. Galloway et al.   MOLECULAR ENDOCRINOLOGY

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

(2015) Tatjana Dorn et al.   STEM CELLS

Nkx2.2 and Nkx2.9 Are the Key Regulators to Determine Cell Fate of Branchial and Visceral Motor Neurons in Caudal Hindbrain

(2015) Wassan Jarrar et al.   PLoS One

Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development

(2014) Lu Zhang et al.   DEVELOPMENTAL BIOLOGY

Islet-1 Is Essential for Pancreatic  -Cell Function

(2014) B. N. Ediger et al.   DIABETES

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Haploinsufficiency ofinsulin gene enhancer protein 1(ISL1) is associated with d-transposition of the great arteries

(2014) Kazutoyo Osoegawa et al.   Molecular Genetics & Genomic Medicine

Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types

(2013) Mandy H. Paul et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system

(2012) Charlotte H. Maden et al.   DEVELOPMENTAL BIOLOGY

Isl1 and Ldb Co-regulators of transcription are essential early determinants of mouse limb development

(2012) Ginat Narkis et al.   DEVELOPMENTAL DYNAMICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Applying selected reaction monitoring to targeted proteomics

(2011) Enrique Calvo et al.   Expert Review of Proteomics

Global landscape of HIV–human protein complexes

(2011) Stefanie Jäger et al.   NATURE

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

(2009) M.-R. Song et al.   DEVELOPMENT

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5

(2009) Ramón A. Espinoza-Lewis et al.   DEVELOPMENTAL BIOLOGY