Review
Gastroenterology & Hepatology
Ross J. Porter, Mark J. Arends, Antonia M. D. Churchhouse, Shahida Din
Summary: The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases predisposes to the development of IBD-CRC. Inflammation can induce mutagenesis, and the molecular pathogenesis of IBD-CRC is well described, while the immunopathogenesis is less understood. The impact of novel immunosuppressive therapies on achieving deep remission in IBD-CRC remains mostly unknown.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Cell Biology
Yingjie Dong, Qiuli Yang, Ruiying Niu, Zhiyuan Zhang, Yijin Huang, Yujing Bi, Guangwei Liu
Summary: Intestinal macrophages play a crucial role in maintaining intestinal homeostasis, inflammation, and cancer development. Understanding their functions and regulatory mechanisms is of great importance for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Immunology
Chen Zhang, Jiantao Zhang, Yanli Zhang, Zian Song, Jing Bian, Huanfa Yi, Zhanchuan Ma
Summary: This study investigated the pathogenesis of ulcerative colitis (UC) and found that neutrophils may promote the conversion of UC into colitis-associated colorectal cancer (CAC). By analyzing transcriptome data, 65 differentially expressed genes related to UC were identified, as well as immune-related biological pathways. The association between neutrophils and UC was confirmed using CIBERSORT and WGCNA analysis. These findings were validated in a mouse model, and 5 genes were identified as potential biomarkers. The results contribute to a better understanding of the pathogenesis of CAC and provide new insights for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Xiaojing Li, Yongheng Yan, Xinru Du, Hao Zhang, Haitao Li, Wei Chen
Summary: This study demonstrates that yogurt consumption can effectively reduce the occurrence of colonic neoplasms in mice and protect against colitis. The activation of lactate receptor GPR81 by D-lactate in yogurt suppresses proinflammatory macrophage polarization, facilitates inflammatory resolution, and consequently inhibits the development of colorectal cancer.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shirley James, Jayasekharan S. Aparna, Anu Babu, Aswathy Mary Paul, Manendra Babu Lankadasari, Subha R. Athira, Sreesha S. Kumar, Yadu Vijayan, Narayanan N. Namitha, Sabira Mohammed, Girijadevi Reshmi, Kuzhuvelil B. Harikumar
Summary: Studies have shown that cardamonin possesses anti-inflammatory properties and potential anti-colorectal cancer effects in both in vitro and in vivo experiments. It can reduce the expression of inflammatory molecules and inhibit tumor formation by modulating miRNA expression.
Review
Immunology
Maorun Zhang, Xiaoping Li, Qi Zhang, Jiahua Yang, Gang Liu
Summary: Colitis-associated colorectal cancer (CAC) is a severe complication of ulcerative colitis (UC), characterized by multiple lesions, worse pathological type, and poor prognosis. Macrophages, as innate immune cells, play a crucial role in both inflammatory response and tumor immunity. Enhanced macrophage infiltration in UC leads to the production of inflammatory cytokines, promoting UC tumorigenesis. Macrophage polarization into M1 has an anti-tumor effect, while M2 polarization promotes tumor growth. Targeting macrophages has shown effectiveness in preventing and treating CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sofia Frigerio, Dalia A. Lartey, Geert R. D'Haens, Joep Grootjans
Summary: Patients with IBD have an increased risk of CRC, which develops in a background of chronic inflammation and pro-inflammatory immune cells. The role of the immunosuppressive microenvironment in these cancers is not well understood, but it has gained more attention in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Wan-Yue Dan, Guan-Zhou Zhou, Li-Hua Peng, Fei Pan
Summary: Colitis-associated colorectal cancer (CAC) refers to a specific cluster of colorectal cancers that develop as a result of prolonged colitis in patients with inflammatory bowel disease (IBD). Patients with IBD have an increased risk of developing CAC, and those with CAC have higher mortality rates compared to individuals with sporadic colorectal cancer. Chronic inflammation is recognized as a major contributor to the pathogenesis of CAC, and multiple immune-mediated pathways, DNA damage pathways, and pathogens are involved. Recent efforts have focused on developing clinical approaches to improve outcomes for CAC patients.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Daotong Li, Yu Feng, Meiling Tian, Xiaosong Hu, Ruimao Zheng, Fang Chen
Summary: The study found that barley leaf supplementation can prevent colorectal cancer by reducing weight loss, inhibiting tumor formation, improving tissue damage, reducing cell proliferation and gene expression levels, and promoting the enrichment of Bifidobacterium.
Article
Gastroenterology & Hepatology
Jing-Lin Liu, Chu-Yi Wang, Tian-Yu Cheng, Youlutuziayi Rixiati, Cheng Ji, Min Deng, Su Yao, Li-Hua Yuan, Yuan-Yuan Zhao, Tong Shen, Jian-Ming Li
Summary: This study revealed the importance of circadian clock in regulating immune cells and related molecules in inflammatory bowel disease and associated colorectal cancer. Disruption of circadian clock leads to increased susceptibility to colitis and dysfunction of immune cells, which may promote the development of colorectal cancer. Low expression of the Bmal1 gene is associated with poorer prognosis in CRC patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Daniel F. Zegarra Ruiz, Dasom V. Kim, Kendra Norwood, Fatima B. Saldana-Morales, Myunghoo Kim, Charles Ng, Ryann Callaghan, Maisha Uddin, Lin-Chun Chang, Randy S. Longman, Gretchen E. Diehl
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease that affects approximately 2 million Americans. This study found that using certain intestinal microbes can improve intestinal inflammation and restrict tumor formation. Macrophage-produced IL-10 and IL-10 signaling to the intestinal epithelium play important roles in both inflammation and tumor development.
Article
Medicine, Research & Experimental
Bingjun Bai, Fei Wu, Kangkang Ying, Yuzi Xu, Lina Shan, Yiming Lv, Xing Gao, Dengyong Xu, Jun Lu, Binbin Xie
Summary: DHA showed inhibitory effects on inflammation and tumor growth in the development of CAC, potentially improving therapeutic outcomes without obvious side effects.
Review
Biochemistry & Molecular Biology
Marco Bocchetti, Maria Grazia Ferraro, Filippo Ricciardiello, Alessandro Ottaiano, Amalia Luce, Alessia Maria Cossu, Marianna Scrima, Wing-Yan Leung, Marianna Abate, Paola Stiuso, Michele Caraglia, Silvia Zappavigna, Tung On Yau
Summary: This review summarizes the major dysregulated miRNAs in CAC and their potential applications in early diagnosis, therapy prediction, and precision treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Giuseppe Biscaglia, Anna Latiano, Stefano Castellana, Rosanna Fontana, Annamaria Gentile, Tiziana Latiano, Giuseppe Corritore, Anna Panza, Marianna Nardella, Giuseppina Martino, Fabrizio Bossa, Francesco Perri, Tommaso Mazza, Angelo Andriulli, Orazio Palmieri
Summary: This study investigated germline alterations in patients with inflammatory bowel disease (IBD)-associated colorectal cancer (CRC). The results showed that a significant proportion of IBD patients with CRC had pathogenic variants in cancer-related genes. Those with pathogenic variants had earlier onset of high-grade dysplasia or CRC compared to patients with benign or unidentified variants. Screening for these genes could help identify IBD patients who require more intensive surveillance for early detection of dysplastic changes.
INFLAMMATORY BOWEL DISEASES
(2022)