Article
Cell Biology
Hyun-Kyoung Kim, Geum-Hwa Lee, Kashi Raj Bhattarai, Myung-Shik Lee, Sung Hoon Back, Hyung-Ryong Kim, Han-Jung Chae
Summary: TMBIM6 enhances autophagy by increasing lysosomal Ca2+ release and subsequently activating TFEB, leading to enhanced lysosome biogenesis to alleviate metabolism stress.
Genetic inactivation of TMBIM6 reduces lysosomal Ca2+ and TFEB nuclear translocation, resulting in increased autophagy flux.
TMBIM6, an ER membrane protein, is suggested to be a lysosomal Ca2+ modulator that coordinates with autophagy to alleviate metabolism stress.
Article
Plant Sciences
Zhenpeng Niu, Guihua Tang, Xuenan Wang, Xu Yang, Yueqin Zhao, Yinyuan Wang, Qin Liu, Fan Zhang, Yuhan Zhao, Xiao Ding, Xiaojiang Hao
Summary: This study investigated the effect of trigonochinene E (TE) on lysosomal biogenesis and autophagy, and revealed the underlying mechanisms. The results showed that TE promotes lysosomal biogenesis and autophagy by activating transcription factors TFEB and TFE3. Mechanistically, TE regulates lysosomal biogenesis and autophagy through the PERK-calcineurin axis and IRE1 alpha-STAT3 axis. Furthermore, TE-induced autophagy protects NP cells from oxidative stress to ameliorate intervertebral disc degeneration (IVDD).
Article
Oncology
Xiaoyuan Wang, Chi Zhang, Na Dong, Hai 'e Xu, Yi Zhou, Dawei Hou
Summary: This study reveals that KDM6B is a critical histone demethylase in thyroid carcinoma (THCA) that promotes THCA proliferation, migration, and invasion by activating autophagy. The E2F1/KDM6B/TFEB axis identified in this study provides potential targets for THCA treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Haojie Zhang, Wenfei Ni, Gaoxiang Yu, Yibo Geng, Junsheng Lou, Jianjun Qi, Yituo Chen, Feida Li, Hantao Ye, Haiwei Ma, Hui Xu, Luying Zhao, Yuepiao Cai, Xiangyang Wang, Huazi Xu, Jian Xiao, Kailiang Zhou
Summary: In this study, the therapeutic value of CRMs for spinal cord injury (SCI) was evaluated using 3,4-DC. The results demonstrated that 3,4-DC reduced glial scar area, motor neuron death, and improved functional recovery after SCI. Further investigation revealed that 3,4-DC promoted functional recovery by upregulating TFEB-mediated autophagy and inhibiting pyroptosis and necroptosis.
Article
Immunology
Shuang Wang, Guangsuo Wang, Weiqing Wu, Zhenglei Xu, Jing Yang, Min Cao, Qi Wang, Jigang Wang, Chuanbin Yang, Wei Zhang
Summary: This study finds that piceatannol, a dietary phenolic compound, can enhance the anticancer immune response induced by the chemotherapy drug oxaliplatin (OXA) through inducing autophagy. Piceatannol promotes the release of immune response-triggering substances and improves the efficacy of chemotherapy. Additionally, piceatannol induces endoplasmic reticulum stress, leading to increased cell surface exposure of calreticulin. The combination of piceatannol and OXA also enhances the anticancer effects in immunocompetent mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ningning Yang, Gaoxiang Yu, Yingying Lai, Jiayi Zhao, Zhuliu Chen, Liang Chen, Yuedong Fu, Pin Fang, Weiyang Gao, Yuepiao Cai, Zhijie Li, Jian Xiao, Kailiang Zhou, Jian Ding
Summary: BF-30 promotes survival of I/R-injured skin flaps by up-regulating autophagy and inhibiting oxidative stress through TFEB-mediated mechanism, which may have potential clinical applications.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ping Wang, Chun Guang Li, Xian Zhou, Shuzhe Ding
Summary: Overexpression of TFEB can improve palmitate-induced insulin resistance by enhancing autophagy and upregulating AMPK activity, thereby increasing intracellular glucose uptake and consumption.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chuanbin Yang, Chengfu Su, Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Zhou Zhu, Sichang Yang, Benjamin Chunkit Tong, Jia Liu, Sravan G. Sreenivasmurthy, Xinjie Guan, Yuxuan Kan, Aston Jiaxi Wu, Alexis Shiying Huang, Jieqiong Tan, Kingho Cheung, Juxian Song, Min Li
Summary: Alzheimer's disease is a neurodegenerative disorder with limited therapeutic options. Celastrol derived from the root extracts of Tripterygium wilfordii can enhance autophagy and decrease phosphorylated Tau aggregates, improving memory.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Dan Zhao, Xiaohong Xie, Qin Tan, Xin Zhao, Dingpei Xing
Summary: The aim of this study was to investigate the potential anti-cancer effects of miR-744 on human gastric cancer cells and the underlying mechanism. The mRNA expression of miR-744 was determined and cell viability, apoptosis, and autophagy were assessed. The results demonstrated that miR-744 had suppressive effects on gastric cancer by inducing apoptosis and autophagy through targeting Heparanase-1 (HPSE-1). Further studies in animal models are needed to validate the anti-cancer effect of miR-744 expression.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Neurosciences
Ki-Ryeong Kim, Sang Eun Park, Ji-Ye Hong, Jae-Young Koh, Dong-Hyung Cho, Jung Jin Hwang, Yang-Hee Kim
Summary: This study reveals that zinc can activate autophagy and lysosomes, promoting the treatment of neurodegenerative diseases through the regulation of transcription factor EB and V-ATPase. Zinc activates lysosomal proteases and lysosomal acidification, reducing protein aggregation and phosphorylation of tau protein, demonstrating its potential therapeutic effect.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Oncology
Min Yang, Bo Tang, Sumin Wang, Li Tang, Dalin Wen, Israel Vlodavsky, Shi-Ming Yang
Summary: This article investigates the role of HPA in gastric cancer cell growth and autophagy and finds that both the enzymatic and non-enzymatic HPA mutant proteins can promote gastric cancer cell growth. Furthermore, HPA and TFEB are significantly elevated in gastric carcinomas. Inhibiting the non-enzymatic function of HPA and TFEB-driven autophagy could have a profound impact on gastric cancer progression.
Article
Multidisciplinary Sciences
Meng Li, Hong-Yi Zhang, Rong-Gui Zhang
Summary: In this study, the role of MFAP2 in chemotherapy resistance in gastric cancer was investigated. It was found that upregulated MFAP2 contributed to increased resistance to chemotherapy drugs and achieved this through inducing autophagy. Therefore, MFAP2 may serve as a potential therapeutic target for overcoming chemotherapy resistance in gastric cancer patients.
Article
Biotechnology & Applied Microbiology
Hongxia Gong
Summary: This study demonstrated that Pino suppresses the proliferation of lung cancer cells by inhibiting autophagy and enhances apoptosis.
Article
Pharmacology & Pharmacy
Feiya Zhou, Xian Zhang, Liangfu Jiang, Shi Li, Yiheng Chen, Jianbin Wu
Summary: Skin flaps are commonly used in tissue reconstruction, but their clinical application is limited by necrosis. Pseudoginsenoside F11 (PF11) has been shown to improve flap viability by enhancing angiogenesis, alleviating apoptosis and oxidative stress through activating autophagy via the AMPK-TFEB signal pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Liang Li, Gao Li, Minbiao Chen, Renzhong Cai
Summary: The combination of AST-IV and BV synergistically affects the viability and apoptosis of lung adenocarcinoma cells, with AST-IV enhancing the inhibitory and apoptotic effects of BV by inhibiting the autophagy pathway.
DRUG DEVELOPMENT RESEARCH
(2022)
