Article
Chemistry, Multidisciplinary
Shenglei Hou, Yuan Zhang, Meng Lian, Xin Xie, Qinghua Lu, Qiqing Zhang
Summary: Here, we present a multifunctional nanodrug (Au NRs@DSFDSs NPs) that combines drug self-framework delivery system (DSFDS) on Au NRs with absorption at 1300 nm through simple condensation polymerization. The aim is to develop an efficient theranostic nanoagent with multi-modal imaging ability and synergistic chemo-photothermal therapy (CT-PTT) for tumor growth monitoring and suppression. This strategy offers a new idea for the design of a multifunctional platform for accurate and effective image-guided tumor treatment.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Physical
Bingyang Chu, Hanzhi Deng, Ting Niu, Ying Qu, Zhiyong Qian
Summary: This review comprehensively summarizes the latest research advances in stimulus-responsive CPT nano-prodrugs, including preparation strategies, responsive release mechanisms, and their applications in cancer therapy. Special focus is placed on the release mechanisms and characteristics of various stimulus-responsive CPT nano-prodrugs and their application in cancer treatment. Furthermore, clinical applications of CPT prodrugs are discussed. Finally, challenges and future research directions for CPT nano-prodrugs are discussed.
Article
Chemistry, Multidisciplinary
Mohammad Irani, Sina Mohammadrezaei Nodeh
Summary: This study investigates the capability of composite and core-shell nanofibers for targeted delivery of anticancer drugs in lung cancer treatment. The results demonstrate that the simultaneous loading of CMPT and PTX anticancer drugs and Au nanoparticles in core-shell nanofibers is more beneficial for lung cancer treatment.
Article
Chemistry, Physical
Xiaohuan Sun, Juan Wang, Ziyao Wang, Chunhua Zhu, Juqun Xi, Lei Fan, Jie Han, Rong Guo
Summary: This study introduces a new synergistic therapy approach using gold nanorods encapsulated in polypyrrole shell for tumor treatment. The structure utilizes dual near-infrared absorptive species to enhance photothermal performance synergistically, and provides high drug encapsulation efficiency and targeted drug release through void space manipulation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Worku Batu Dirersa, Tzu-Chun Kan, Girum Getachew, Aswandi Wibrianto, Sonjid Ochirbat, Akash Rasal, Jungshan Chang, Jia-Yaw Chang
Summary: Iron-containing Fenton nanocatalysts have shown great potential for clinical use due to their effective antitumor activity and low toxicity. In this study, FeMnOx nanoparticles were synthesized using cation exchange to enhance Fenton reactions in the tumor microenvironment, leading to improved chemodynamic therapy and chemotherapy. The nanoparticles exhibited excellent therapeutic potential, as demonstrated in in vitro and animal studies.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, Research & Experimental
Dorota Bartusik-Aebisher, Grzegorz Chrzanowski, Zuzanna Bober, David Aebisher
Summary: This study aimed to investigate the Trastuzumab-dendrimer-fluorine drug delivery system by synthesizing and characterizing a series of fluorinated dendrimers. The results from electrophoresis, HPLC, and LC-MS techniques showed the potential and efficiency of the synthesized drug delivery system. Three-dimensional cell culture experiments and MRI measurements confirmed the efficacy of the novel system in treating breast cancer cells with Her-2 overexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Michal Zuk, Weronika Gaweda, Agnieszka Majkowska-Pilip, Magdalena Osial, Marcin Wolski, Aleksander Bilewicz, Pawel Krysinski
Summary: This study successfully synthesized multifunctional nanoparticle conjugates with magnetic and anticancer properties, showing high potential for effective in vivo applications.
Article
Chemistry, Multidisciplinary
Gangfeng Jiang, Nannan Wang, Lina Jia, Hongli Che, Lihui Wang, Jingyu Yang, Hui Xu, Chunfu Wu, Mingzhe Liu
Summary: The study successfully prepared DNA-conjugated nanohydrogels using copolymerization and hybridization methods, demonstrating their potential application in cancer cell targeted therapy.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Atieh Jahangiri-Manesh, Marziyeh Mousazadeh, Shirinsadat Taji, Abbas Bahmani, Atefeh Zarepour, Ali Zarrabi, Esmaeel Sharifi, Mostafa Azimzadeh
Summary: This review provides a comprehensive overview of the properties, synthesis methods, toxicity, and therapeutic applications of gold nanorods. Gold nanorods have unique physical, optical, and chemical properties that make them suitable for various biomedical applications, including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. The review discusses the potential, challenges, and future perspectives of gold nanorods in the field of biomedicine.
Article
Multidisciplinary Sciences
Vinu Krishnan, Kevin Peng, Apoorva Sarode, Supriya Prakash, Zongmin Zhao, Sergey K. Filippov, Kristina Todorova, Brittney R. Sell, Omar Lujano, Shirin Bakre, Anusha Pusuluri, Douglas Vogus, Kenneth Y. Tsai, Anna Mandinova, Samir Mitragotri
Summary: DOCTOR is a novel topical treatment for skin cancer that demonstrates high cancer-cell killing specificity and superior safety to healthy skin cells compared to conventional treatments. In vivo and ex vivo studies confirm its efficacy in treating cancerous lesions without irritation or systemic absorption, making it a safe and potent option for clinical use.
Article
Pharmacology & Pharmacy
Zhihui Dong, Zhuoshan Huang, Senlin Li, Ying Wang, Yandan Yao, Xianzhu Yang, Xiaoding Xu
Summary: Tumor microenvironment (TME) pH-responsive nanoparticles (NPs) were developed for systemic mRNA delivery to reverse trastuzumab resistance in breast cancer. These NPs, consisting of a pH-liable polymer and lipid, could efficiently deliver PTEN mRNA into tumor cells and up-regulate PTEN expression, ultimately blocking the PI3K/Akt signaling pathway and reversing trastuzumab resistance in breast cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Yi Jin, Mhd Anas Tomeh, Peng Zhang, Mingzhu Su, Xiubo Zhao, Zhiqiang Cai
Summary: This study utilized a newly developed microfluidic swirl mixer to fabricate temperature-sensitive liposomes (TSL) for the treatment of breast cancer through near-infrared stimulation. The results demonstrated that AP-3/ICG@TSL significantly inhibited the growth of breast cancer both in vitro and in vivo without causing damage to other organs. These findings suggest that the AP-3/ICG@TSL manufactured using the microfluidic swirl mixer is a promising drug delivery system for breast cancer therapy.
Article
Chemistry, Multidisciplinary
Andreia Almeida, Flavia Castro, Carlos Resende, Marlene Lucio, Simo Schwartz, Bruno Sarmento
Summary: This study demonstrates the potential role of chitosan-based camptothecin-loaded micelles for reducing colorectal cancer progression in vitro and in vivo, with a good safety profile in normal tissues.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Tara Shabab, Onur Bas, Bronwin L. Dargaville, Akhilandeshwari Ravichandran, Phong A. Tran, Dietmar W. Hutmacher
Summary: This study combines melt-extrusion based 3D printing and porogen leaching to develop tunable multiphasic scaffolds for dental tissue regeneration. The scaffolds are highly adjustable in terms of mechanical properties, degradation kinetics, and surface morphology. The research also demonstrates improved cell attachment, proliferation, and extracellular matrix production on these multiscale scaffolds compared to single-scale counterparts, indicating their potential for enhanced tissue regeneration. Furthermore, the study explores the use of these scaffolds as drug delivery devices and shows that sustained drug release can be achieved. These findings strongly support further development of these scaffolds for dental tissue regeneration applications.
Article
Multidisciplinary Sciences
Dipak Barua
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2018)
Article
Engineering, Chemical
Mohammad Aminul Islam, Satyaki Roy, Sajal K. Das, Dipak Barua
Article
Biochemistry & Molecular Biology
Laura L. Lee, James R. Crosby, Gabriel M. Rubinstein, Tunyaboon Laemthong, Ryan G. Bing, Christopher T. Straub, Michael W. W. Adams, Robert M. Kelly
Review
Biochemical Research Methods
James R. Crosby, Tunyaboon Laemthong, April M. Lewis, Christopher T. Straub, Michael W. W. Adams, Robert M. Kelly
CURRENT OPINION IN BIOTECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
James R. Crosby, Tunyaboon Laemthong, Ryan G. Bing, Ke Zhang, Tania N. N. Tanwee, Gina L. Lipscomb, Dmitry A. Rodionov, Ying Zhang, Michael W. W. Adams, Robert M. Kelly
Summary: This study characterizes the utilization of hemicellulose by the extreme thermophile Caldicellulosiruptor bescii by integrating genomic reconstruction, transcriptomic data, operon structures, and biochemical characteristics of key enzymes. The comparative genomics of the genus also reveals conserved and divergent mechanisms for hemicellulose utilization across the 15 sequenced species. These findings are essential for understanding lignocellulose degradation and can contribute to enhancing lignocellulose conversion for biofuel and chemical production through metabolic engineering efforts.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tunyaboon Laemthong, Ryan G. Bing, James R. Crosby, Michael W. W. Adams, Robert M. Kelly
Summary: Caldicellulosiruptor species have the potential to solubilize lignocellulosic carbohydrates and convert them into bio-based chemicals and fuels. They possess SLH-GHs enzymes that mediate attachment to biomass and hydrolysis of carbohydrates. Expression of SLH-GHs from other Caldicellulosiruptor species in C. bescii greatly improves its ability to degrade sugar cane bagasse and poplar.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Agricultural Engineering
Ryan G. Bing, Morgan J. Carey, Tunyaboon Laemthong, Daniel J. Willard, James R. Crosby, Daniel B. Sulis, Jack P. Wang, Michael W. W. Adams, Robert M. Kelly
Summary: Naturally occurring microbial contaminants were found in plant biomasses from common bioenergy crops and agricultural wastes. Among the candidate microbial platforms for biomass conversion, Acetivibrio thermocellus and Caldicellulosiruptor bescii were able to degrade a wide variety of plant biomasses. However, only A. thermocellus was significantly affected by the presence of indigenous microbial populations. The study indicates that the thermophilic threshold of 75 degrees Celsius should be avoided to prevent sterilizing pre-treatments on biomass and allow native thermophilic microbes to compete with engineered microbes and form desirable by-products.
BIORESOURCE TECHNOLOGY
(2023)
Article
Microbiology
Ryan G. G. Bing, Daniel J. J. Willard, Mohamad J. H. Manesh, Tunyaboon Laemthong, James R. R. Crosby, Michael W. W. Adams, Robert M. M. Kelly
Summary: The genome sequences of three thermophilic, lignocellulolytic Caldicellulosiruptor species were successfully assembled, improving upon previous fragmented assemblies. All 14 classified Caldicellulosiruptor spp. now have complete genomes. Genome closure will enhance bioinformatic analysis of these species, facilitating the identification of carbohydrate-active enzymes (CAZymes) and comparison with other Caldicellulosiruptor species and lignocellulolytic microorganisms.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Biochemistry & Molecular Biology
Tunyaboon Laemthong, Ryan G. Bing, James R. Crosby, Mohamad J. H. Manesh, Michael W. W. Adams, Robert M. Kelly
Summary: Caldicellulosiruptor species have the ability to solubilize carbohydrates in lignocellulosic biomass. Tapirins, non-catalytic binding proteins in Caldicellulosiruptor species, bind tightly to cellulose and scavenge carbohydrates in natural environments. This study aimed to investigate the effect of tapirin overexpression on lignocellulose carbohydrate hydrolysis and biomass solubilization. The results showed that enhanced binding to the substrate did not improve biomass solubilization but may improve the conversion of released lignocellulose carbohydrates to fermentation products.
Article
Biotechnology & Applied Microbiology
Chatchol Kongsinkaew, Supenya Chittapun, Chanitchote Piyapittayanun, Viroj Boonyaratanakornkit, Sarintip Sooksai, Kittisak Ajariyakhajorn, Soisuda Pornpukdeewattana, Warawut Krusong, Tunyaboon Laemthong, Theppanya Charoenrat
Summary: The instability of protein expression in Pichia pastoris strains can be resolved by modifying the traditional fermentation process. In this study, a four-stage fermentation process was used to express the CAP2 peptide in P. pastoris KM71H. By increasing cell concentration and controlling glycerol feed using exponential and dissolved oxygen tension (DOT) stat feeding strategies, the overall methanol consumption and CAP2 productivity were significantly improved.
FERMENTATION-BASEL
(2023)
Article
Microbiology
Ryan G. Bing, Daniel J. Willard, Mohamad J. H. Manesh, Tunyaboon Laemthong, James R. Crosby, Michael W. W. Adams, Robert M. Kelly
Summary: Complete genome sequences of two anaerobic, thermophilic bacteria isolated from wheat straw, namely (hemi)cellulolytic Thermoclostridium stercorarium subspecies strain RKWS1 (3,029,933 bp) and hemicellulolytic Thermoanaerobacter species strain RKWS2 (2,827,640 bp), are reported in this study. The discovery of indigenous thermophiles in plant biomass suggests a greater ubiquity of high-temperature microorganisms than previously believed.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Mathematical & Computational Biology
Mohammad Aminul Islam, Sutapa Barua, Dipak Barua
BMC SYSTEMS BIOLOGY
(2017)
Article
Biochemical Research Methods
M. D. Shahinuzzaman, Dipak Barua
JOURNAL OF COMPUTATIONAL BIOLOGY
(2017)