Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials

Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

(2022) Manoj V Maddali et al.   Lancet Respiratory Medicine

Redefining critical illness

(2022) David M. Maslove et al.   NATURE MEDICINE

Biological Subphenotypes of ARDS Show Prognostic Enrichment in Mechanically Ventilated Patients Without ARDS

(2021) Nanon F.L. Heijnen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Latent Class Analysis Reveals COVID-19-related ARDS Subgroups with Differential Responses to Corticosteroids

(2021) Pratik Sinha et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study

(2021) Pratik Sinha et al.   THORAX

Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis

(2021) Mary K Dahmer et al.   Lancet Respiratory Medicine

Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials

(2021) Pratik Sinha et al.   EBioMedicine

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials

(2020) Pratik Sinha et al.   Lancet Respiratory Medicine

Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time*

(2020) Matthew Schwede et al.   CRITICAL CARE MEDICINE

Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study

(2020) Rene A. Posma et al.   Annals of Intensive Care

Machine Learning Classifier Models Can Identify ARDS Phenotypes Using Readily Available Clinical Data

(2020) Pratik Sinha et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Subphenotypes in critical care: translation into clinical practice

(2020) Kiran Reddy et al.   Lancet Respiratory Medicine

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

(2020) Pratik Sinha et al.   Lancet Respiratory Medicine

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome*

(2019) Georgios D. Kitsios et al.   CRITICAL CARE MEDICINE

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters

(2018) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study

(2018) Bengt Gårdlund et al.   JOURNAL OF CRITICAL CARE

Stability of ARDS subphenotypes over time in two randomised controlled trials

(2018) Kevin Delucchi et al.   THORAX

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

(2018) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study

(2018) Pratik Sinha et al.   INTENSIVE CARE MEDICINE

Phenotypes in acute respiratory distress syndrome

(2018) Pratik Sinha et al.   Current Opinion in Critical Care

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis

(2017) L D Bos et al.   THORAX

Clinical trials in acute respiratory distress syndrome: challenges and opportunities

(2017) Michael A Matthay et al.   Lancet Respiratory Medicine

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

ARDS Subphenotypes Respond Differently to Randomized Fluid Management Strategy

(2016) Katie R Famous et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

(2014) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

(2009) Hector R Wong et al.   BMC Medicine

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

(2008) James A. Russell et al.   NEW ENGLAND JOURNAL OF MEDICINE