Betaine regulates steroidogenesis, endoplasmic reticulum stress response and Nrf2/HO-1 antioxidant pathways in mouse Leydig cells under hyperglycaemia condition

High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Müller retinal cells in vitro

(2022) Jesús Silvestre Albert-Garay et al.   Scientific Reports

The Fate of Leydig Cells in Men with Spermatogenic Failure

(2022) Daria Adamczewska et al.   Life-Basel

Betaine Reduces Lipid Anabolism and Promotes Lipid Transport in Mice Fed a High-Fat Diet by Influencing Intestinal Protein Expression

(2022) Haitao Hu et al.   Foods

Evaluating the effects of betaine on testicular ischemia/reperfusion injury induced by torsion/detorsion in the rat

(2022) Mohammad Sarlak et al.   ANDROLOGIA

Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfkβ, NLRP3, JNK signaling pathways

(2022) Mohammad Reza Tabandeh et al.   RESEARCH IN VETERINARY SCIENCE

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

(2022) Vy Ngo et al.   Antioxidants

Diabetes Type 1 Negatively Influences Leydig Cell Function in Rats, Which is Partially Reversible By Insulin Treatment

(2021) Isabel Viola Wagner et al.   ENDOCRINOLOGY

Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†

(2021) Jin-Yong Chung et al.   BIOLOGY OF REPRODUCTION

MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes

(2021) Li Hu et al.   MOLECULAR MEDICINE

Chemical and Green ZnO nanoparticles ameliorated adverse effects of cisplatin on histological structure, antioxidant defense system and neurotrophins expression in rat hippocampus

(2021) Naeem Erfani Majd et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial

(2021) Hadi Nobari et al.   Journal of the International Society of Sports Nutrition

The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype

(2021) Eva Zatecka et al.   Frontiers in Endocrinology

Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2

(2020) Yuanyuan Tian et al.   Oxidative Medicine and Cellular Longevity

Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration

(2020) Kosar Abbasi Samie et al.   Systems Biology in Reproductive Medicine

Cell surface expression of 78 kDa glucose regulated protein (GRP78) mediates diabetic nephropathy

(2019) Richard Van Krieken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells

(2019) Zhi Chen et al.   Reproductive Biology and Endocrinology

Oxidative Stress, NF-κB-Mediated Inflammation and Apoptosis in the Testes of Streptozotocin–Induced Diabetic Rats: Combined Protective Effects of Malaysian Propolis and Metformin

(2019) Victor Udo Nna et al.   Antioxidants

Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways

(2019) Ya-Ping Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response

(2018) Jia-mei Yang et al.   MOLECULES

Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells

(2018) Zhaoyu Du et al.   Cell Death & Disease

Undiagnosed prediabetes is highly prevalent in primary infertile men - results from a cross-sectional study

(2018) Luca Boeri et al.   BJU INTERNATIONAL

Diabetes-induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin

(2018) Victor Udo Nna et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Role of Follicle-Stimulating Hormone in Spermatogenesis

(2018) Olayiwola O. Oduwole et al.   Frontiers in Endocrinology

The International Glossary on Infertility and Fertility Care, 2017

(2017) Fernando Zegers-Hochschild et al.   FERTILITY AND STERILITY

Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review

(2017) Constanze C Maresch et al.   HUMAN REPRODUCTION UPDATE

Molecular signal networks and regulating mechanisms of the unfolded protein response

(2017) Jing Gong et al.   Journal of Zhejiang University-SCIENCE B

Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2 Akita+/− mouse model of type 1 diabetes

(2017) Constanze C. Maresch et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Vitamin D supplement improved testicular function in diabetic rats

(2016) Chenzhao Ding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats

(2016) Chen-Xu Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress

(2016) Yun-Tao Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet

(2016) Majid Nazari et al.   International Journal of Peptide Research and Therapeutics

Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway

(2016) Yuping Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

(2016) Stefan W. Ryter et al.   Translational Research

N-acetylcysteine effectively mitigates cadmium-induced oxidative damage and cell death in Leydig cellsin vitro

(2015) Smita Khanna et al.   DRUG AND CHEMICAL TOXICOLOGY

Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats

(2015) Masoud Alirezaei et al.   Journal of Physiological Sciences

Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function

(2014) Yonggang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Testicular hyperthermia induces Unfolded Protein Response signaling activation in spermatocyte

(2013) Jung-Hak Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms beyond glucose transport in diabetes-related male infertility

(2013) M.G. Alves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model

(2013) Xin Jiang et al.   TOXICOLOGY LETTERS

Acute effects of hexabromocyclododecane on Leydig cell cyclic nucleotide signaling and steroidogenesis in vitro

(2013) Svetlana Fa et al.   TOXICOLOGY LETTERS

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

(2011) A. A. Merchant et al.   BLOOD

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress: A Common Factor in Testicular Dysfunction

(2008) T. T. Turner et al.   JOURNAL OF ANDROLOGY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY