Stepwise in vitro screening of MMV pathogen box compounds against Plasmodium falciparum to identify potent antimalarial candidates

Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus modelling study

(2022) Oliver J Watson et al.   Lancet Microbe

High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine

(2021) Judith Straimer et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence of Artemisinin-Resistant Malaria in Africa

(2021) Betty Balikagala et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole Cell Phenotypic Screening Of MMV Pathogen Box identifies Specific Inhibitors of Plasmodium falciparum late-stage development and egress.

(2020) Alok Tanala Patra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

(2020) Madeline G. Dans et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Tolerance of Gambian Plasmodium falciparum to Dihydroartemisinin and Lumefantrine detected by Ex vivo Parasite Survival Rate Assay (PSRA)

(2020) Haddijatou Mbye et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening the Pathogen Box against Plasmodium sexual stages using a new nanoluciferase based transgenic line of P. berghei identifies transmission-blocking compounds.

(2018) Juliana Calit et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combating multidrug-resistant Plasmodium falciparum malaria

(2017) Aung Myint Thu et al.   FEBS Journal

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

(2017) Tanya Paquet et al.   Science Translational Medicine

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

(2016) Beatriz Baragaña et al.   JOURNAL OF MEDICINAL CHEMISTRY

Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

(2016) Marc Hafner et al.   NATURE METHODS

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

An open investigation of the reproducibility of cancer biology research

(2014) Timothy M Errington et al.   eLife

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS