A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

(2023) Lucas Heils et al.   Toxins

A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure

(2023) Meryem T. Ok et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Binary Toxin Expression by Clostridioides difficile Is Associated With Worse Disease

(2022) Mary K Young et al.   Open Forum Infectious Diseases

An Update on Clostridioides difficile Binary Toxin

(2022) Adrián Martínez-Meléndez et al.   Toxins

Human duodenal organoid‐derived monolayers serve as a suitable barrier model for duodenal tissue

(2022) Franziska Weiß et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of Toxoplasma gondii and Other Protozoan Infections

(2021) David Holthaus et al.   Frontiers in Cellular and Infection Microbiology

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection

(2021) Salvador López-Cárdenas et al.   Gut Microbes

The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells

(2021) Florian Stieglitz et al.   Frontiers in Microbiology

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis

(2021) Megan R. Beggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption

(2020) Praveen Kumar Nattramilarasu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene set enrichment for reproducible science: comparison of CERNO and eight other algorithms

(2019) Joanna Zyla et al.   BIOINFORMATICS

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

(2017) S M Krug et al.   Mucosal Immunology

Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon

(2017) R Bücker et al.   Mucosal Immunology

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

dupRadar: a Bioconductor package for the assessment of PCR artifacts in RNA-Seq data

(2016) Sergi Sayols et al.   BMC BIOINFORMATICS

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

(2016) Liang Tao et al.   NATURE

Fecal Microbiota Transplantation for the Management of Clostridium difficile Infection

(2015) Krishna Rao et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Interaction of theClostridium difficileBinary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR)

(2015) Sarah Hemmasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

(2014) Pengfei Yuan et al.   CELL RESEARCH

α-Haemolysin ofEscherichia coliin IBD: a potentiator of inflammatory activity in the colon

(2014) Roland Bücker et al.   GUT

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

(2014) Kelli L VanDussen et al.   GUT

Difference in F-Actin Depolymerization Induced by Toxin B from the Clostridium difficile Strain VPI 10463 and Toxin B from the Variant Clostridium difficile Serotype F Strain 1470

(2013) Martin May et al.   Toxins

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

Glucocorticoid receptor is indispensable for physiological responses to aldosterone in epithelial Na+ channel induction via the mineralocorticoid receptor in a human colonic cell line

(2011) Theresa Bergann et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

LSR defines cell corners for tricellular tight junction formation in epithelial cells

(2011) S. Masuda et al.   JOURNAL OF CELL SCIENCE

Claudin-2, a component of the tight junction, forms a paracellular water channel

(2010) R. Rosenthal et al.   JOURNAL OF CELL SCIENCE

Epithelial Tight Junctions in Intestinal Inflammation

(2009) Joerg D. Schulzke et al.   Annals of the New York Academy of Sciences

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Tight Junction Proteins Claudin-2 and -12 Are Critical for Vitamin D-dependent Ca2+ Absorption between Enterocytes

(2008) Hiroki Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction

(2007) Qiurong Li et al.   CLINICAL IMMUNOLOGY