Explainable multi-task learning improves the parallel estimation of polygenic risk scores for many diseases through shared genetic basis

Leveraging pleiotropic association using sparse group variable selection in genomics data

(2022) Matthew Sutton et al.   BMC Medical Research Methodology

Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis

(2022) Yi Zhou et al.   Frontiers in Genetics

Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis

(2022) Xueyao Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK biobank

(2022) Matthew Bracher-Smith et al.   SCHIZOPHRENIA RESEARCH

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

(2022) Tian Ge et al.   Genome Medicine

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

(2022) Emmanuel O. Adewuyi et al.   Communications Biology

Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

(2022) Michael Elgart et al.   Communications Biology

Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

(2021) Zhenhuang Zhuang et al.   BMC Medicine

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies

(2021) Jinyoung Byun et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition

(2021) Nadav Brandes et al.   Scientific Reports

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

(2021) Carla Márquez-Luna et al.   Nature Communications

Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status

(2020) Damian Gola et al.   GENETIC EPIDEMIOLOGY

Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases

(2020) Christopher DeBoever et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Incidence of cancer after asthma development: two independent population-based cohort studies

(2020) Ala Woo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

(2020) Maria Teresa Landi et al.   NATURE GENETICS

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

(2020) Minta Thomas et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Deep neural network improves the estimation of polygenic risk scores for breast cancer

(2020) Adrien Badré et al.   JOURNAL OF HUMAN GENETICS

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

(2020) Sara R. Rashkin et al.   Nature Communications

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma

(2017) Katherine J. Ransohoff et al.   Oncotarget

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2015) Robert Maier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MultiBLUP: improved SNP-based prediction for complex traits

(2014) Doug Speed et al.   GENOME RESEARCH

Genome-wide association study identifies three loci associated with melanoma risk

(2009) D Timothy Bishop et al.   NATURE GENETICS