Treg cells as potential cellular targets for functionalized nanoparticles in cancer therapy

Memory of Inflammation in Regulatory T Cells

(2016) Joris van der Veeken et al.   CELL

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

(2016) Shi-Yong Li et al.   JOURNAL OF CONTROLLED RELEASE

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates

(2016) Lisa Gamrad et al.   Scientific Reports

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Directed Interactions of Block Copolypept(o)ides with Mannose-binding Receptors: PeptoMicelles Targeted to Cells of the Innate Immune System

(2015) Philipp Heller et al.   MACROMOLECULAR BIOSCIENCE

Nanoparticles and antigen-specific T-cell therapeutics: a comprehensive study on uptake and release

(2015) Oliver Zupke et al.   Nanomedicine

In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles

(2015) Leonard Kaps et al.   Advanced Healthcare Materials

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

(2014) L. E. Clough et al.   JOURNAL OF IMMUNOLOGY

New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes

(2014) Bettina Krieg et al.   PHARMACEUTICAL RESEARCH

Investigating the optimal size of anticancer nanomedicine

(2014) L. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

(2014) Sebastian Hartmann et al.   Advanced Healthcare Materials

Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques

(2013) Alexander Birke et al.   BIOMACROMOLECULES

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Interferon-  Suppresses cAMP to Disarm Human Regulatory T Cells

(2013) N. Bacher et al.   CANCER RESEARCH

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

(2013) B. Kwong et al.   CANCER RESEARCH

FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells

(2013) Dewan Md Sakib Hossain et al.   IMMUNITY

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

(2013) Madhav D. Sharma et al.   IMMUNITY

Synthesis of Nanostructured and Biofunctionalized Water-in-Oil Droplets as Tools for Homing T Cells

(2013) Ilia Platzman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression

(2013) Hozefa S Bandukwala et al.   NATURE IMMUNOLOGY

Kinetics of IL-6 Production Defines T Effector Cell Responsiveness to Regulatory T Cells in Multiple Sclerosis

(2013) Bettina Trinschek et al.   PLoS One

Neuropilin 1 guides regulatory T cells into VEGF-producing melanoma

(2013) Wiebke Hansen   OncoImmunology

TRAIL suppresses tumor growth in mice by inducing tumor-infiltrating CD4+CD25+ Treg apoptosis

(2012) Zhijuan Diao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells

(2012) L. Huang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 Inhibits Regulatory T Cells and Improves the Proliferation and Cytotoxic Activity of Cytokine-induced Killer Cells

(2012) Guohe Lin et al.   JOURNAL OF IMMUNOTHERAPY

Differential Effects of IL-12 on Tregs and Non-Treg T Cells: Roles of IFN-γ, IL-2 and IL-2R

(2012) Jingxian Zhao et al.   PLoS One

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery

(2012) J. Predina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple treg suppressive modules and their adaptability

(2012) James B. Wing et al.   Frontiers in Immunology

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Repression of Cyclic Adenosine Monophosphate Upregulation Disarms and Expands Human Regulatory T Cells

(2011) M. Klein et al.   JOURNAL OF IMMUNOLOGY

A Role for IL-27 in Limiting T Regulatory Cell Populations

(2011) E. D. Tait Wojno et al.   JOURNAL OF IMMUNOLOGY

Effective Melanoma Immunotherapy with Interleukin-2 Delivered by a Novel Polymeric Nanoparticle

(2011) H. Yao et al.   MOLECULAR CANCER THERAPEUTICS

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

(2011) Marc Beyer et al.   NATURE IMMUNOLOGY

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

(2011) M. Vaeth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response

(2011) Lei Sun et al.   TRANSPLANT IMMUNOLOGY

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

(2010) K. Klages et al.   CANCER RESEARCH

Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation

(2010) Melanie Fassbender et al.   CELLULAR IMMUNOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored after dendritic cell-based vaccination

(2010) Anita Correll et al.   EXPERIMENTAL DERMATOLOGY

Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients

(2010) Ingrid M.E. Desar et al.   INTERNATIONAL JOURNAL OF CANCER

The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles

(2010) Helen Lee et al.   MOLECULAR PHARMACEUTICS

Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery

(2010) Jason Park et al.   MOLECULAR PHARMACEUTICS

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

(2009) Elias Gounaris et al.   CANCER RESEARCH

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression

(2009) T. Bopp et al.   JOURNAL OF IMMUNOLOGY

Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice

(2009) K. Lahl et al.   JOURNAL OF IMMUNOLOGY

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses

(2009) Ana Lucia Dominguez et al.   VACCINE

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124

(2008) Ommoleila Molavi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin

(2008) Minghuang Hong et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

(2008) Paolo Decuzzi et al.   PHARMACEUTICAL RESEARCH

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE