Review
Chemistry, Multidisciplinary
Mahendra Rai, Avinash P. Ingle, Joanna Trzcinska-Wencel, Magdalena Wypij, Shital Bonde, Alka Yadav, Gabriela Kratosova, Patrycja Golinska
Summary: Nanobiotechnology is a rapidly emerging field with significant potential, and biogenically synthesized silver nanoparticles exhibit unique physicochemical properties that enable a wide range of applications in medicine, food, agriculture, and industries.
Article
Pharmacology & Pharmacy
Dave Lumen, Shiqi Wang, Ermei Makila, Surachet Imlimthan, Mirkka Sarparanta, Alexandra Correia, Christina Westerveld Haug, Jouni Hirvonen, Helder A. Santos, Anu J. Airaksinen, Werner Filtvedt, Jarno Salonen
Summary: Porous silicon is a biocompatible and biodegradable material that can be used in biomedical applications. A novel two-step production method for PSi nanoparticles, based on centrifuge chemical vapor deposition and electrochemical post-processing, has been developed for industrial scale production. The physical and biological quality of the cCVD-produced nanoparticles is comparable to those produced conventionally from silicon wafers.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Samia Aboushoushah, Wafa Alshammari, Reem Darwesh, Nihal Elbaily
Summary: The study suggests that curcumin-coated iron oxide nanoparticles (Cur-IONPs) exhibit good safety and non-toxicity in a mouse model. Cur-IONPs primarily accumulate in the liver, spleen, and brain, with minimal presence in the kidney, and can be completely cleared after a certain period of time.
Article
Environmental Sciences
Zannatul Ferdous, Suhail Al-Salam, Priya Yuvaraju, Badreldin H. Ali, Abderrahim Nemmar
Summary: This study found that pulmonary exposure to AgNPs caused oxidative stress markers, inflammation, DNA damage, and distribution to remote organs including liver, spleen, kidney, and brain. These findings provide a novel mechanistic insight into the pathophysiological effects and tissue distribution of lung exposure to AgNPs.
Article
Multidisciplinary Sciences
Van Phuc Nguyen, Wei Qian, Yanxiu Li, Bing Liu, Michael Aaberg, Jessica Henry, Wei Zhang, Xueding Wang, Yannis M. Paulus
Summary: This study presents a new type of ultrapure chain-like gold nanoparticle (CGNP) clusters with excellent biocompatibility and photostability. Upon validation in living rabbits after conjugation with RGD peptides, they demonstrate a 17-fold increase in PAM signal and a 176% increase in OCT signal, showing their potential for in vivo imaging.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Aziz B. Mirkasymov, Ivan Zelepukin, Ilya N. Ivanov, Iaroslav B. Belyaev, Dzhuliia Sh Dzhalilova, Daria B. Trushina, Alexey Yaremenko, Vsevolod Yu Ivanov, Maxim P. Nikitin, Petr Nikitin, Andrei Zvyagin, Sergey M. Deyev
Summary: In this study, a new method using ferrihydrite particles to block the mononuclear phagocyte system (MPS) and improve nanomedicine delivery efficacy was proposed. The surface coating of ferrihydrite particles with carboxymethyl-dextran significantly prolonged the circulation time of magnetic nanoparticles in the bloodstream and increased tumor targeted delivery. Furthermore, high doses of ferrihydrite showed low toxicity, with rapid recovery of toxicological parameters after 3 days.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Miroslav Almasi, Anna Alexovic Matiasova, Monika Sulekova, Eva Benova, Juraj Sevc, Lucia Vahovska, Maksym Lisnichuk, Vladimir Girman, Adriana Zelenakova, Alexander Hudak, Vladimir Zelenak
Summary: A drug delivery system based on mesoporous particles MCM-41 was modified by a photo-sensitive ligand to control the release of Naproxen sodium salt. The physicochemical properties and drug release mechanism were studied in detail, showing effective photo-cleavage reaction of the ligand after UV-light stimulation.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Ryan D. Mellor, Ijeoma F. Uchegbu
Summary: This article reviews the applications of gold nanoparticles in the field of nanotechnology. By tuning the particle size, their physicochemical properties can be controlled, allowing for various applications in vivo. The effects of particle size on optical properties, opsonization, cellular internalization, renal clearance, biodistribution, tumor accumulation, and toxicity are discussed in detail.
Article
Biochemistry & Molecular Biology
Gabor Kiraly, John Chinonso Egu, Zoltan Hargitai, Ilona Kovacs, Istvan Fabian, Jozsef Kalmar, Gabor Szeman-Nagy
Summary: The study showed that mesoporous aerogel microparticles injected into the peritoneum of mice did not accumulate at the injection site in the abdominal cavity, but were found to accumulate in the cortical part of the parathymic lymph nodes, indicating their potential entry into the lymphatic circulation. This biodistribution pathway could be utilized for designing drug delivery systems targeting abdominal cancers that spread via the lymphatic circulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
K. D. Patil, S. B. Bagade, S. C. Bonde
Summary: The present study explores the therapeutic potential of gelatin nanoparticles as a carrier for the delivery of linezolid, a repurposed drug for tuberculosis treatment. The formulation of linezolid loaded mannosylated gelatin nanoparticles showed promising results in reducing the dose, dosing frequency, and toxic adverse effects, ultimately improving patient compliance.
MATERIALS TECHNOLOGY
(2022)
Article
Polymer Science
Ladislav Androvic, Lucie Woldrichova, Klaudia Jozefjakova, Michal Pechar, Geoffrey M. Lynn, Dana Kankova, Lenka Malinova, Richard Laga
Summary: A series of novel star polymer nanocarriers have been developed to improve the therapeutic effects of drugs, with suitable sizes for tumor uptake and programmable degradability.
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Chemistry, Multidisciplinary
Linqiang Mei, Junsong Guo, Rendong He, Xuefeng Ding, Wenyan Yin, Zhanjun Gu
Summary: Lead-based perovskite nanoparticles (Pb-PNPs) have superior optoelectronic properties and are potential alternatives for photovoltaics materials. However, little is known about their adverse effects on the gastrointestinal tract system. This study investigates the biodistribution, biotransformation, potential gastrointestinal toxicity, and effect on gut microbiota after oral exposure to CsPbBr3 perovskite nanoparticles (CPB PNPs). The results show that high doses of CPB PNPs can transform into different lead-based compounds and accumulate in the gastrointestinal tract, leading to colitis-like symptoms and significant alterations in the gut microbiota.
Review
Pharmacology & Pharmacy
Abraham J. Domb, Ghorbanali Sharifzadeh, Victoria Nahum, Hossein Hosseinkhani
Summary: Nanomaterials are widely used in biomedical applications, but concerns have been raised about their potential risks to tissues, cells, and organs. Understanding the underlying mechanisms of nanotoxicity and conducting in vitro and in vivo experiments are crucial for assessing their toxicity. Physicochemical properties of nanomaterials play a significant role in determining their toxicity.
Article
Chemistry, Multidisciplinary
Qianyu Bai, Yeru Wang, Luoyan Duan, Xiaomu Xu, Yusheng Hu, Yue Yang, Lei Zhang, Zhaoping Liu, Huihui Bao, Tianlong Liu
Summary: The novel nanomaterial Cu-doped-ZnO nanocrystals (CZON) have attracted attention for their potential in cancer therapy and antibacterial properties. The study found that CZON induced dose-dependent toxicity and autophagy primarily in the liver and splenic organs, potentially through oxidative stress mechanisms.
Article
Nanoscience & Nanotechnology
Timea Kacso, Eban A. Hanna, Fallon Salinas, Carlos E. Astete, Ede Bodoki, Radu Oprean, Paul P. Price, Vinson P. Doyle, Colin A. R. Bonser, Jeffrey A. Davis, Cristina M. Sabliov
Summary: This study synthesized zein nanoparticles and lignin-graft-poly(lactic-co-glycolic) acid nanoparticles using surfactants and applied them as antifungal seed treatments on soybeans. The results showed that the treated seeds had similar germination rates and plant health compared to the control group, indicating that these nanoparticles are safe and effective delivery systems for active compounds in seed treatments.
APPLIED NANOSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Victoria Dupuis, Constantin Cerbu, Lucjan Witkowski, Adrian-Valentin Potarniche, Maria Cristina Timar, Monika Zychska, Cristina M. Sabliov
Summary: This review provides a synthesis of the last ten years of research on nanodelivery systems for essential oils (EOs) and their potential as an alternative to antibiotics in human and veterinary therapy. Nanodelivery systems seem to be able to overcome the limitations of using essential oils alone. The choice of essential oil and nanodelivery system influences therapeutic efficacy. The review assesses the characteristics of nanomaterials used for essential oil delivery and their impact on functionality, as well as successful applications. More quantitative and in vivo studies are needed before the adoption of EOs loaded NPs as an alternative to antibiotics.
Article
Entomology
Colin A. R. Bonser, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Research shows that nanoparticles can be an effective tool for managing agricultural pests, but their unintended effects on insects should be evaluated before using them in agroecosystems. In this study, chronic parental and generational exposure to positively charged zein nanoparticles and methoxyfenozide-loaded zein nanoparticles were evaluated on Chrysodeixis includens. The study found that the nanoparticles had different effects on the insect's population dynamics, with the methoxyfenozide-loaded nanoparticles being more deleterious than the positively charged nanoparticles.
ENVIRONMENTAL ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomas Komprda, Zbysek Sladek, Monika Vicenova, Jana Simonova, Gabriela Franke, Katarina Kacvinska, Cristina Sabliov, Carlos E. Astete, Lenka Leva, Vendula Popelkova, Andrej Batik, Lucy Vojtova, Bretislav Lipovy, Milena Matejovicova
Summary: The utilization of PLGA nanoparticles with entrapped fish oil in collagen-based scaffolds for cutaneous wound healing showed promising results in a porcine model. The NP/FO treatment had advantages compared to FO alone and tended to have similar effects to NP/MUP treatment, suggesting it as a suitable alternative for wound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ioana Craciun, Carlos E. Astete, Dorin Boldor, Merilyn H. Jennings, Jake D. Gorman, Cristina M. Sabliov, Tammy R. Dugas
Summary: This study aimed to design a novel drug-coated balloon using a polymeric nanodelivery system for sustained release of polyphenols to reduce restenosis in patients with peripheral artery disease (PAD) after balloon angioplasty. The results showed that the nanoparticle system with quercetin covalently attached had the highest sustained release and anti-proliferative effect, while maintaining adhesion even under calcification conditions. Additionally, the ultrasound coating method produced a uniform balloon coating.
Article
Chemistry, Multidisciplinary
Sheyda Shakiba, Saba Shariati, Haoran Wu, Carlos E. Astete, Rafael Cueto, Elham H. Fini, Debora F. Rodrigues, Cristina M. Sabliov, Stacey M. Louie
Summary: This research presents the development and application of a multi-detector AF4 method to study drug loading and release from polymeric nanoparticles. By using multiple online detectors, the researchers were able to determine the release mechanism and draw important conclusions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Entomology
Colin A. R. Bonser, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Previous research found that positively charged zein nanoparticles were toxic to neonates of Anticarsia gemmatalis Hubner and other noctuid pests, but the specific mechanisms were unknown. This study ruled out the hypotheses that toxic effects were caused by surfactant charges and antifeedant capabilities. It also found that both (+)ZNP and its cationic surfactant DDAB decreased antioxidant levels in A. gemmatalis neonates, suggesting inhibition of antioxidant levels. These findings contribute to the understanding of potential modes of action of biopolymeric nanoparticles.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2023)
Article
Entomology
C. A. R. Bonser, C. Tamez, J. C. White, C. E. Astete, C. M. Sabliov, J. A. Davis
Summary: Biopolymeric nanoparticles have the potential to improve insecticide efficacy through improved absorption, coverage, and permeability, while protecting the active ingredient and extending efficacy. The experiments showed that positively charged zein nanoparticles loaded with methoxyfenozide had comparable efficacy to a commercial product.
JOURNAL OF INSECT SCIENCE
(2023)
Article
Agronomy
Colin A. R. Bonser, Jaya Borgatta, Jason C. White, Carlos E. Astete, Cristina M. Sabliov, Jeffrey A. Davis
Summary: Biopolymer nanoparticles, designed to be biocompatible and degradable, have been found to have no negative effects on plant growth, yield, and herbivore susceptibility, making them suitable for use in agriculture.
AGROSYSTEMS GEOSCIENCES & ENVIRONMENT
(2023)
Article
Agriculture, Multidisciplinary
Thanida Chuacharoen, Cristina M. Sabliov
Summary: In this study, curcumin-loaded zein nanoparticles were used to control anthracnose disease in postharvest mangoes. The nanoparticles showed higher antimicrobial activity and significantly reduced disease severity, prolonging the shelf life of mangoes.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Eban A. Hanna, Omar E. Mendez Lopez, Fallon Salinas, Carlos E. Astete, Carlos Tamez, Yi Wang, Haoran Wu, Brian D. Eitzer, Wade H. Elmer, Stacey Louie, Jason C. White, Cristina M. Sabliov
Summary: Zein nanoparticles (ZNPs) have been proposed as effective delivery systems to enhance the translocation of nonsystemic agrochemicals in soybean plants. In this study, ZNPs with entrapped methoxyfenozide (MFZ) were synthesized and used to facilitate the translocation of MFZ from the roots to the leaves and stems of soybean plants, resulting in an increased MFZ concentration in the leaves over time.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Maria Tizu, Ion Maruntelu, Bogdan Mihai Cristea, Claudiu Nistor, Nikolay Ishkitiev, Zornitsa Mihaylova, Rozaliya Tsikandelova, Marina Miteva, Ana Caruntu, Cristina Sabliov, Bogdan Calenic, Ileana Constantinescu
Summary: Polymeric nanoparticles have been widely used as a delivery vehicle for active compounds in various medical applications due to their biocompatibility, stability, controlled release, and reduced toxicity. This study investigates the interaction between two types of polymeric nanoparticles (PLGA and PLGA/chitosan) and two types of stem cells (OKSCs and SHEDs) in the oral cavity. The results show that nanoparticle uptake depends on stem cell type, incubation time, particle concentration, and surface properties.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Agriculture, Multidisciplinary
Omar E. Mendez, Carlos E. Astete, Rafael Cueto, Brian Eitzer, Eban A. Hanna, Fallon Salinas, Carlos Tamez, Yi Wang, Jason C. White, Cristina M. Sabliov
Summary: This study explores the use of lignin nanoparticles (LNPs) to enhance the translocation of the non-systemic pesticide methoxyfenozide (MFZ) in soybean plants. The results show that LNPs effectively transfer MFZ from the hydroponic suspension to the roots, and then from the roots to the leaves within 24 hours. The concentration and total amount of MFZ translocated by LNPs are higher than those of free MFZ, although the translocation efficiency is higher for free MFZ.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2022)
