Article
Materials Science, Biomaterials
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: This study developed a new nanocomposite for the treatment of bone metastasis by inhibiting the destruction of bones. The nanocomposite, composed of BPs loaded onto OxCNHs using CaPs as mediators, showed promising potential for localized treatment of bone destruction caused by metastasis.
BIOMATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Yun Ju Choi, Jun Woo Park, Yong Lim, Sungbaek Seo, Dae Youn Hwang
Summary: The study found that oral administration of nanoplastics (NP) for 2 weeks resulted in high accumulation in the liver, kidneys, and intestine of ICR mice, inducing severe inflammatory and oxidative stress responses. Both NP and coagulation-based purified NP had an impact on the biodistribution, toxicity, and inflammatory response in mice.
Review
Chemistry, Multidisciplinary
Catia Domingues, Ana Santos, Carmen Alvarez-Lorenzo, Angel Concheiro, Ivana Jarak, Francisco Veiga, Isabel Barbosa, Marilia Dourado, Ana Figueiras
Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.
Article
Chemistry, Multidisciplinary
Su Yin Chaw, Wisna Novera, Ann-Marie Chacko, Tina Tzee Ling Wong, Subbu Venkatraman
Summary: Subconjunctival administration of nanocarriers can enhance drug bioavailability in specific parts of the eye by overcoming blood-ocular barriers. Different characteristics of liposomes (charge, size, cholesterol content, and lipid saturation) influence their distribution in ocular and corporeal tissues. Optimizing liposome design is necessary to control the temporal and spatial bioavailability and clearance of nanocarriers from the eye, improving the efficacy and safety of ocular therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Paul Strasser, Bianca Montsch, Silvia Weiss, Haider Sami, Christoph Kugler, Sonja Hager, Hemma Schueffl, Robert Mader, Oliver Brueggemann, Christian R. R. Kowol, Manfred Ogris, Petra Heffeter, Ian Teasdale
Summary: The design and synthesis of novel bottlebrush polymers (PPz-g-PGA) with exceptional control over their structure and molecular dimensions have been reported. These polymers show outstanding aqueous solubility, ultra-high multivalency, and biodegradability, making them ideal as nanomedicines. They exhibit enhanced cellular uptake, pharmacokinetics, and tumor accumulation, offering valuable insights into the influence of architecture on the in vivo performance of nanomedicines.
Article
Chemistry, Multidisciplinary
Swapnali Londhe, Shagufta Haque, Sanchita Tripathy, Sreedhar Bojja, Chitta Ranjan Patra
Summary: The advancement of nanotechnology has led to the experimental development of silver nitroprusside nanoparticles (AgNNPs) for breast cancer therapy, which showed positive results in in vitro and in vivo experiments. AgNNPs exhibited biocompatibility with normal cell lines and cytotoxicity against cancer cell lines. They also demonstrated anti-angiogenic behavior and inhibited orthotopic breast tumor growth in mice. The possible molecular mechanisms for their anti-cancer activity were investigated. AgNNPs have the potential to be used as a generalized nanomedicine for breast and other cancers after proper biosafety evaluation in the future.
Article
Chemistry, Multidisciplinary
Mathew R. Schnorenberg, Katrina M. Hawley, Anika T. Thomas-Toth, Elyse A. Watkins, Yu Tian, Jeffrey M. Ting, Logan B. Leak, Isadora M. Kucera, Michal M. Raczy, Andrew L. Kung, Jeffrey A. Hubbell, Matthew V. Tirrell, James L. LaBelle
Summary: This research identified a potential treatment synergy in DLBCL by combining the reactivation of p53 with a peptide and modulation of the BCL-2 family using a BH3-mimetic. However, the combination treatment was highly toxic in vivo. To overcome this, a targeted nanomedicine delivery platform was developed for the delivery of the peptide, resulting in improved therapeutic efficacy and reduced toxicity.
Article
Biochemistry & Molecular Biology
Yifeng Luo, Gang Niu, Hui Yi, Qingling Li, Zhiqiang Wu, Jing Wang, Juan Yang, Bo Li, Yuan Peng, Ying Liang, Weiwei Wang, Zhenwei Peng, Xintao Shuai, Yu Guo
Summary: miR-101?3p restores ferroptosis in tumor cells by targeting TBLR1, promoting apoptosis and inhibiting proliferation. Nanomedicine can deliver miR-101?3p to tumor cells for ferroptosis recovery, potentially serving as an effective therapy to inhibit tumor proliferation.
Article
Chemistry, Multidisciplinary
Jessica Fernanda Affonso de Oliveira, Soo Khim Chan, Anthony O. Omole, Vanshika Agrawal, Nicole F. Steinmetz
Summary: Cowpea mosaic virus (CPMV) is a potent immunomodulator that can be used as an in situ vaccine for cancer immunotherapy. Studies have shown that humans are exposed to CPMV and develop immune responses against it, as well as other plant viruses and phages. Additionally, CPMV has been shown to be safe in agronomical settings.
Review
Medicine, Research & Experimental
Qinghu Zeng, Xiangyi Ma, Yangmeihui Song, Qiqing Chen, Qiuling Jiao, Liqiang Zhou
Summary: Nanomedicines have great potential in anticancer therapy, but they are limited by self-protection mechanisms and treatment resistance of cancer cells. Recent studies have shown that regulating cell death can enhance the therapeutic efficiency of tumors. This article introduces various strategies of regulated cell death-mediated synergistic tumor nanotherapeutics and discusses the coordination mechanisms.
Article
Chemistry, Multidisciplinary
Jae Hyung Park
Summary: This article discusses the significance of exosomes as intercellular messengers and their applications in disease diagnosis and treatment. The author aims to address delivery challenges of exosomes using expertise in the field of nanomedicine to develop improved therapies. The article summarizes recent preclinical efforts in the author's research group to regulate the fate of exosomes in vivo, along with future development ambitions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Elzbieta Czarniewska, Krzysztof Sielicki, Klaudia Maslana, Ewa Mijowska
Summary: This study investigated the in vivo biocompatibility of borophene nanoflakes with hemocytes in the Tenebrio molitor model organism. The results showed that the nanoflakes did not induce hemocytotoxicity, reactive oxygen species generation, disturbance in mitochondrial membrane potential, or interference with phagocytosis. These findings provide new insights into the potential biomedical applications of borophene.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Kuo Li, Dan Li, Cheng-Hsuan Li, Pengfei Zhuang, Chunmei Dai, Xiangka Hu, Dahao Wang, Yuanye Liu, Xifan Mei, Vincent M. Rotello
Summary: Studies have shown that ultra-small noble metal nanoclusters have comprehensive therapeutic effects for wound healing, promoting cell proliferation and migration while decreasing inflammation.
Article
Environmental Sciences
Mohammad Behzadi Tayemeh, Hesamoddin Abaei, Kirill Golokhvast, Hamid Salari Joo, Konstantin Pikula, Seyed Ali Johari, Borhan Mansouri
Summary: This study evaluates and compares the toxicity of AgNPs, TiO(2)NPs, and SiO(2)NPs individually and combined on the life cycle of A. salina. AgNPs showed acute toxicity while SiO(2)NPs and TiO(2)NPs induced chronic toxicity in a concentration- and time-dependent manner. The presence of AgNPs shifted the reproductive mode from ovoviviparity to oviparity and the coexistence of AgNPs with SiO(2)NPs or TiO(2)NPs caused infertility. Overall, the individual toxicity of the nanoparticles was AgNPs > TiO(2)NPs > SiO2NPs, and the combined exposure of AgNPs-SiO(2)NPs was more threatening to A. salina than AgNPs-TiO(2)NPs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Applied
A. Anitha, Nicholas L. Fletcher, Zachary H. Houston, Kristofer J. Thurecht, Lisbeth Grondahl
Summary: The study evaluated the biodistribution of ultrapure ALG in BALB/c mice over a 14-day period, revealing liver and spleen uptake of the polymer, as well as uptake by macrophages in the spleen.
CARBOHYDRATE POLYMERS
(2021)
Editorial Material
Pharmacology & Pharmacy
Hossein Hosseinkhani
Summary: Developing 3D living systems can significantly improve biological tools, drug discovery, lead identification, and therapeutic approaches. The miniaturization of this approach allows for more experiments to be performed in a simpler manner.
CURRENT DRUG DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Eliel Ben-David, Abraham J. Domb, Haixing Liao, Awanish Kumar, Issac Nissenbaum, Matthias Stechele, Peter Siman, Natalie Greenbaum, Naama Lev Cohain, S. Nahum Goldberg
Summary: The study evaluated the degradation rate and imaging effects of three biodegradable polymer markers in a mouse model, with significant differences observed in their visibility and absorption rate on CT and MRI.
Article
Biochemistry & Molecular Biology
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: The alternating structure and hydrophobic side chains of polyanhydrides contribute to their stability. The addition of phenyl moieties and tuning their distance from anhydride bonds significantly improves the stability of polyanhydrides.
Article
Pharmacology & Pharmacy
Radhakanta Ghosh, Yuvaraj Arun, Peter Siman, Abraham J. Domb
Summary: Polyanhydrides are synthesized by melt-polycondensation of diacid monomers and excess acetic anhydride to form stable polymers with controlled molecular weight. The synthesized aliphatic polyanhydrides have controllable molecular weight and low polydispersity, making them suitable for potential use as drug carriers. In vitro drug release studies show promising results for poly(sebacic acid) as a candidate for controlled drug delivery applications.
Review
Biochemistry & Molecular Biology
Pulikanti Guruprasad Reddy, Abraham J. Domb
Summary: Polyanhydrides (PAs) are synthetic biodegradable polymers used as controlled drug delivery vehicles. They are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation. PAs have surface-eroding characteristics and have been developed into various drug delivery carriers. The rate of drug delivery is controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, hydrophobicity, pH of the release medium, and device size.
Article
Chemistry, Medicinal
Pulikanti Guruprasad Reddy, Abraham J. Domb
Summary: This work presents the formation and characterization of thymol phenolate salts, which are representatives of phenol-containing bioactive molecules. Various thymol salts were synthesized and investigated for their physicochemical properties. It was found that the thymol salts exhibited improved solubility, thermal stability, and evaporation rate compared to thymol.
Article
Virology
Eyal Klein, Elisheva Smith, Chen Klap, Elena Bakelman, Arie Ophir, Aviad Sela, Elena Poverenov, Dmitry Rein, Yachin Cohen, Dan Eliahu, Shai Shahal, Guy Mechrez, Karthik Ananth Mani, Pulikanti Guruprasad Reddy, Abraham J. Domb, Nadav Pass, Aviv Dombrovsky
Summary: This study tested four root-coating technologies to mitigate soil-mediated Tomato brown rugose fruit virus (ToBRFV) infection. The formulations based on methylcellulose (MC), polyvinyl alcohol (PVA), silica Pickering emulsion, and super-absorbent polymer (SAP) with chlorinated-trisodium phosphate (Cl-TSP) disinfectant showed low percentages of soil-mediated ToBRFV infection and had no adverse effect on plant growth.
Review
Polymer Science
Elif Yuce-Erarslan, Abraham (Avi) J. Domb, Haytam Kasem, Vladimir N. Uversky, Orkid Coskuner-Weber
Summary: In biology and medicine, intrinsically disordered synthetic polymers, which mimic the characteristics of disordered proteins, are highly flexible and self-organizing, making them useful in various biomedical applications, such as drug delivery and organ design. The development of new synthesis and characterization methods is important for providing these polymers for medical use. This study presents strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on mimicking intrinsically disordered proteins.
Review
Pharmacology & Pharmacy
Hossein Hosseinkhani, Abraham J. Domb, Ghorbanali Sharifzadeh, Victoria Nahum
Summary: The development of biological methods has generated interest in the possibility to regenerate human tissues. Stem cell research, gene therapy, and tissue engineering have advanced tissue and organ regeneration technology. Technical issues still remain in gene therapy, especially in the clinical use of viral vectors. Non-viral gene transfection agents are emerging as potentially safe and effective alternatives for treating genetic and acquired diseases.
Article
Biochemistry & Molecular Biology
Muhammad AbdEl-haq, Awanish Kumar, Fatima-ezzahra Ait Mohand, Nataly Kravchenko-Balasha, Yakir Rottenberg, Abraham J. Domb
Summary: The study investigated the development of paclitaxel-loaded polymeric nanoparticles for brain tumor treatment. Poly(lactide-glycolide) (PLGA) nanoparticles with a size of 216 nm and containing 10% w/w paclitaxel were administered through intranasal and intravenous routes to rats. Both routes of administration resulted in significant accumulation of paclitaxel in brain tissue, liver, and kidney, with no observed toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was similar to that of free paclitaxel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Pulikanti Guruprasad Reddy, Tan Hu, Meital Reches, Abraham J. Domb
Summary: This study developed a series of chlorine-rich transition metal complexes/TBA salts of Na-DCC for extended chlorine release studies. These DCC-salts exhibited poor water solubility and slow decomposition chlorine release compared to Na-DCC. Moreover, the DCC-salts demonstrated excellent antiviral and antibacterial properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tovi Shapira-Furman, Abraham J. Domb
Summary: This report introduces a novel approach of nano formulation using stereo-interaction mechanism with poly(D-lactide)-polyethylene glycol (D-PLA-PEG) to address the challenges of controlled drug delivery for peptide and protein therapeutics. The study demonstrates that nano particles formed by the interaction between water-soluble D-PLA-PEG and insulin can achieve sustained release of insulin, showing potential application in diabetes treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Awanish Kumar, Yifat Lamberti, Rafael Y. Lewis, Eyal Marco, Abraham J. Domb
Summary: The aim of this study was to determine the type of material in the unknown fabrics excavated from archaeological sites in Israel using advanced material technology. Using various analytical methods, it was confirmed that these fabrics are composed of synthetic materials such as nylon 6, polyester, and polyacrylonitrile (PAN). The developed method offers a rapid and effective means of identifying archaeological fabrics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Pulikanti Guruprasad Reddy, Ayala Bar-Hai, Amnon Hoffman, Sir Marc Feldmann, Abraham J. Domb
Summary: This study explores the synthesis and characterization of metal and ammonium phenolate salts using CBD as an example. The conversion of CBD into salts significantly enhances its water solubility, thus improving its therapeutic effectiveness. The findings provide valuable insights into the potential use of CBD salts in medicine.
BIOORGANIC CHEMISTRY
(2023)
