16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin

Regulation of adult-born and mature neurons in stress response and antidepressant action in the dentate gyrus of the hippocampus

(2022) Eri Segi-Nishida et al.   NEUROSCIENCE RESEARCH

Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice.

(2021) Justin J Botterill et al.   JOURNAL OF NEUROSCIENCE

miR-218-2 regulates cognitive functions in the hippocampus through complement component 3–dependent modulation of synaptic vesicle release

(2021) Si-Yao Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism

(2021) Alessandra Bertoni et al.   MOLECULAR PSYCHIATRY

Structural and mechanistic insights into secretagogin-mediated exocytosis

(2020) Jiao Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A limbic circuitry involved in emotional stress-induced grooming

(2020) Ming-Dao Mu et al.   Nature Communications

16p11.2 Copy Number Variations and Neurodevelopmental Disorders

(2020) Benjamin Rein et al.   TRENDS IN NEUROSCIENCES

Multiple Origins of Secretagogin Expressing Cortical GABAergic Neuron Precursors in the Early Human Fetal Telencephalon

(2020) Ayman Alzu’bi et al.   Frontiers in Neuroanatomy

SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons

(2019) Kirill Zaslavsky et al.   NATURE NEUROSCIENCE

Functional brain connectivity in a rodent seizure model of autistic-like behavior

(2019) Philippe R. Mouchati et al.   EPILEPSY & BEHAVIOR

SCGN deficiency results in colitis susceptibility

(2019) Luis F Sifuentes-Dominguez et al.   eLife

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

CRISPR interference-based specific and efficient gene inactivation in the brain

(2018) Yi Zheng et al.   NATURE NEUROSCIENCE

Excitatory and Inhibitory Neurons Utilize Different Ca 2+ Sensors and Sources to Regulate Spontaneous Release

(2018) Nicholas A. Courtney et al.   NEURON

Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions

(2018) Carly Demopoulos et al.   Scientific Reports

Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions

(2018) Thomas Arbogast et al.   HUMAN MOLECULAR GENETICS

Early brain development in infants at high risk for autism spectrum disorder

(2017) Heather Cody Hazlett et al.   NATURE

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation

(2017) Smita Yadav et al.   NEURON

Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration

(2017) János Hanics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

16p11.2 deletion and duplication: Characterizing neurologic phenotypes in a large clinically ascertained cohort

(2016) Kyle J. Steinman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Secretagogin affects insulin secretion in pancreatic  -cells by regulating actin dynamics and focal adhesion

(2016) S.-Y. Yang et al.   BIOCHEMICAL JOURNAL

The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition

(2016) Loyse Hippolyte et al.   BIOLOGICAL PSYCHIATRY

Hippocampal-Prefrontal Theta Oscillations Support Memory Integration

(2016) Alexander R. Backus et al.   CURRENT BIOLOGY

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

(2016) M C Marchetto et al.   MOLECULAR PSYCHIATRY

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency

(2016) Stefanie Grabrucker et al.   Frontiers in Behavioral Neuroscience

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes

(2016) Thomas Arbogast et al.   PLoS Genetics

Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities

(2016) Debra D’Angelo et al.   JAMA Psychiatry

DrosophilaHomolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions

(2016) Sang Mee Park et al.   Experimental Neurobiology

The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

(2015) J. Pucilowska et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin Interneurons of Hippocampus Tune Population Activity at Theta Frequency

(2015) Bénédicte Amilhon et al.   NEURON

Association between SNAP-25 gene polymorphisms and cognition in autism: functional consequences and potential therapeutic strategies

(2015) D Braida et al.   Translational Psychiatry

Brain MRI abnormalities and spectrum of neurological and clinical findings in three patients with proximal 16p11.2 microduplication

(2014) Isabel Filges et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

(2014) Manuel Irimia et al.   CELL

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

(2014) R. A. Romanov et al.   EMBO JOURNAL

Amygdala Inputs to the Ventral Hippocampus Bidirectionally Modulate Social Behavior

(2014) A. C. Felix-Ortiz et al.   JOURNAL OF NEUROSCIENCE

The hippocampal CA2 region is essential for social memory

(2014) Frederick L. Hitti et al.   NATURE

Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome

(2014) Thomas Portmann et al.   Cell Reports

Mechanisms and Functions of Theta Rhythms

(2013) Laura Lee Colgin   Annual Review of Neuroscience

Recognition memory and theta-gamma interactions in the hippocampus

(2013) John B. Trimper et al.   HIPPOCAMPUS

Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice

(2013) Annabella Pignataro et al.   Frontiers in Behavioral Neuroscience

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Interpersonal body and neural synchronization as a marker of implicit social interaction

(2012) Kyongsik Yun et al.   Scientific Reports

Doc2 Is a Ca2+ Sensor Required for Asynchronous Neurotransmitter Release

(2011) Jun Yao et al.   CELL

Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion

(2011) Mikael C. Bauer et al.   Molecular BioSystems

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Doc2 Supports Spontaneous Synaptic Transmission by a Ca2+-Independent Mechanism

(2011) Zhiping P. Pang et al.   NEURON

Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

(2011) G. Horev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Start/stop signals emerge in nigrostriatal circuits during sequence learning

(2010) Xin Jin et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release

(2010) A. J. Groffen et al.   SCIENCE

A synaptic trek to autism

(2009) Thomas Bourgeron   CURRENT OPINION IN NEUROBIOLOGY

Extending the phenotype of recurrent rearrangements of 16p11.2: Deletions in mentally retarded patients without autism and in normal individuals

(2009) E.K. Bijlsma et al.   European Journal of Medical Genetics

Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion

(2009) Christopher Barkus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adult hippocampal neurogenesis is involved in anxiety-related behaviors

(2009) J-M Revest et al.   MOLECULAR PSYCHIATRY

Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons

(2009) Jan Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

(2009) Catalina Betancur et al.   TRENDS IN NEUROSCIENCES

Association between Microdeletion and Microduplication at 16p11.2 and Autism

(2008) Lauren A. Weiss et al.   NEW ENGLAND JOURNAL OF MEDICINE