IK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene, ofd1

Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development

(2022) Hannah M. Wesselman et al.   Journal of Developmental Biology

Loss of splicing factor IK impairs normal skeletal muscle development

(2021) Hye In Ka et al.   BMC BIOLOGY

The role of splicing factors in retinitis pigmentosa: links to cilia

(2021) Dale W. Maxwell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor

(2021) Eleni Leventea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

(2020) Hye In Ka et al.   Cell Death Discovery

Regulation of autophagosome biogenesis by OFD1‐mediated selective autophagy

(2020) Manuela Morleo et al.   EMBO JOURNAL

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome instability caused by mutations in the genes involved in transcription and splicing

(2019) Kimihiko Sugaya   RNA Biology

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

(2019) Sandra Keiper et al.   Nature Communications

Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly

(2017) Qingrui Sun et al.   International Journal of Biological Sciences

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Left–Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis

(2017) Daniel T. Grimes et al.   TRENDS IN GENETICS

Antennas of organ morphogenesis: the roles of cilia in vertebrate kidney development

(2016) Amanda N. Marra et al.   GENESIS

Cilia in vertebrate left–right patterning

(2016) Agnik Dasgupta et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED

(2016) Alexander K.C. Ulrich et al.   STRUCTURE

IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype

(2015) Isabelle Perrault et al.   JOURNAL OF MEDICAL GENETICS

Zygotic Genome Activation During the Maternal-to-Zygotic Transition

(2014) Miler T. Lee et al.   Annual Review of Cell and Developmental Biology

Cilia and Diseases

(2014) Jason M. Brown et al.   BIOSCIENCE

Multiciliated Cells

(2014) Eric R. Brooks et al.   CURRENT BIOLOGY

Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases

(2014) Sunyi Lee et al.   FEBS LETTERS

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

The role of primary cilia in the development and disease of the retina

(2013) Gabrielle Wheway et al.   Organogenesis

RED, a Spindle Pole-associated Protein, Is Required for Kinetochore Localization of MAD1, Mitotic Progression, and Activation of the Spindle Assembly Checkpoint

(2012) Pei-Chi Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ofd1 Controls Dorso-Ventral Patterning and Axoneme Elongation during Embryonic Brain Development

(2012) Anna D'Angelo et al.   PLoS One

Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1

(2011) C. A. M. Lopes et al.   JOURNAL OF CELL SCIENCE

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Ofd1 is required in limb bud patterning and endochondral bone development

(2010) Sabrina Bimonte et al.   DEVELOPMENTAL BIOLOGY

The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development

(2010) Jianxin A. Yu et al.   DEVELOPMENTAL BIOLOGY

Ofd1, a Human Disease Gene, Regulates the Length and Distal Structure of Centrioles

(2010) Veena Singla et al.   DEVELOPMENTAL CELL

Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway

(2010) Alessandro Zullo et al.   HUMAN MOLECULAR GENETICS

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch

(2010) N. E. Hellman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of oral-facial-digital syndrome, type 1

(2009) Marina Macca et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy

(2008) F. Friedrichs et al.   GENOME RESEARCH

Convergent extension movements and ciliary function are mediated by ofd1 , a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene

(2008) Maria I. Ferrante et al.   HUMAN MOLECULAR GENETICS

Foxj1 transcription factors are master regulators of the motile ciliogenic program

(2008) Xianwen Yu et al.   NATURE GENETICS

The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos

(2008) Jennifer L Stubbs et al.   NATURE GENETICS