A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants

(2023) Ogo Egbuna et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila.

(2022) Lea Gerstner et al.   KIDNEY INTERNATIONAL

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

(2021) Gizelle M. McCarthy et al.   Disease Models & Mechanisms

Lessons From APOL1 Animal Models

(2021) Teruhiko Yoshida et al.   Frontiers in Medicine

Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity

(2021) Etty Kruzel-Davila et al.   iScience

Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

(2020) Joseph A Giovinazzo et al.   eLife

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function

(2020) Somenath Datta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

(2020) Hidefumi Wakashin et al.   BMC Nephrology

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

(2019) Shrijal S. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

APOL1Genotype and Renal Function of Black Living Donors

(2018) Mona D. Doshi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition

(2018) Vinod Kumar et al.   AMERICAN JOURNAL OF PATHOLOGY

ApoL1 Overexpression Drives Variant-Independent Cytotoxicity

(2017) John F. O'Toole et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Apolipoprotein L1 Gene Effects on Kidney Transplantation

(2017) Barry I. Freedman et al.   SEMINARS IN NEPHROLOGY

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease

(2016) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death

(2016) Yulong Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

(2015) Atanu K. Khatua et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Protein domains of APOL1 and its risk variants

(2015) Xiqian Lan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Vascular smooth muscle cells contribute to APOL1-induced podocyte injury in HIV milieu

(2015) Xiqian Lan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells

(2015) Dongmei Cheng et al.   JOURNAL OF LIPID RESEARCH

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Basic Domain of HIV-Tat Transactivating Protein Is Essential for Its Targeting to Lipid Rafts and Regulating Fibroblast Growth Factor-2 Signaling in Podocytes Isolated from Children with HIV-1-Associated Nephropathy

(2014) X. Xie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

(2013) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

The APOL1 Gene and Allograft Survival after Kidney Transplantation

(2011) A. M. Reeves-Daniel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

MYH9 and APOL1 are both associated with sickle cell disease nephropathy

(2011) Allison E. Ashley-Koch et al.   BRITISH JOURNAL OF HAEMATOLOGY

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans

(2010) B. I. Freedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9

(2010) Giulio Genovese et al.   KIDNEY INTERNATIONAL

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

(2008) Helen Weavers et al.   NATURE