Article
Nanoscience & Nanotechnology
Sheng Wang, Hailin Shen, Qiulian Mao, Qing Tao, Guotao Yuan, Lingli Zeng, Ziying Chen, Yunjiao Zhang, Liang Cheng, Jingzhong Zhang, Hui Dai, Chunhong Hu, Yue Pan, Yonggang Li
Summary: A macrophage loaded with a photothermal nanoprobe was developed to cross the blood-brain barrier and accumulate into deep gliomas for multimodal imaging and guided surgery purposes. This nanoplatform shows promise for achieving accurate diagnosis, imaging-guided surgery, and effective photothermal therapy for gliomas.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Wenxue Hu, Wenyao Zhen, Mengchao Zhang, Wei Wang, Xiaodan Jia, Shangjie An, Yue Wang, Zhuo Guo, Xiue Jiang
Summary: A novel all in one NIR-II responsive nanoplatform based on nickel selenide@polydopamine nanocomposites is reported for dual-model imaging-guided photothermal therapy. The nanoplatform shows promise for efficient MRI-guided photothermal therapy for treating malignant tumor.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Physical
Bing Hu, Yanjun Cui, Xi Yang, Xia Xu, Baadal Jushi Janani, Ali Fakhri
Summary: This project presents the synthesis of Ti-Sn doped Cu-ferrite nanoparticles with different ratios using sol gel/precipitation route. The properties of these nanoparticles were investigated, including their X-ray diffraction analysis, degradation activity of dyes under visible light irradiation, and potential applications in magnetic resonance imaging and drug release under near infrared laser irradiation.
SURFACES AND INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Yefeng Lin, Ke Zhou, Shaobo Zhang, Yijun Lu, Yuan He, Hongji Liu, Xiangfu Meng, Yong Qian, Xingyu Wang, Xinyi Shi, Wenchu Lin, Junchao Qian, Hui Wang
Summary: A carbon-coated magnetite nanoclusters (CCMNCs) has been developed for near-infrared (NIR-II) photothermal-enhanced chemodynamic anti-cancer therapy. The CCMNCs not only serve as a contrast agent for magnetic resonance imaging, but also convert NIR-II irradiation into heat for killing cancer cells. The synergistic effect of chemodynamic-photothermal treatment shows a superior therapeutic efficacy for cancer treatment.
SCIENCE CHINA-MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Minchuan Luo, Hiroshi Yukawa, Kazuhide Sato, Makoto Tozawa, Masato Tokunaga, Tatsuya Kameyama, Tsukasa Torimoto, Yoshinobu Baba
Summary: This study presents a multifunctional nanoprobe for bimodal imaging and photothermal-enhanced targeted therapy. The nanoprobe exhibits intense fluorescence and magnetic resonance imaging capabilities for sensitive and high-resolution imaging of tumors in living mice. Additionally, it can generate localized heat and reactive oxygen species, achieving excellent therapeutic efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ming Zhang, Wentao Wang, Mohsen Mohammadniaei, Tao Zheng, Qicheng Zhang, Jon Ashley, Shunjie Liu, Yi Sun, Ben Zhong Tang
Summary: The study introduces a new type of nanoparticles, BK@AIE NPs, which can enhance transportation and accumulation inside tumors by activating BTB adenosine receptors. These nanoparticles can be used in photothermal therapy to treat deep-seated tumors and inhibit tumor progression, resulting in an extended survival span for mice.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Mingming Yin, Junwei Tong, Fanling Meng, Chenchen Liu, Xiaoming Liu, Fang Fang, Zhenyan He, Xiaojuan Qin, Chengbo Liu, Dong Ni, Yuting Gao, Huageng Liang, Xiaoping Zhang, Liang Luo
Summary: This study demonstrates the development of a symbiotic 2D nanohybrid that combines carbon nanomaterials and clay nanomaterials for synergistic cancer therapy and diagnosis. The nanohybrid exhibits high photothermal conversion efficiency and the ability to generate reactive oxygen species, allowing for simultaneous photothermal therapy, chemodynamic therapy, and photoacoustic/magnetic imaging for precision nanomedicine.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Senthilkumar Thirumurugan, Kayalvizhi Samuvel Muthiah, Rajalakshmi Sakthivel, Mei-Yi Liao, Hitoshi Kasai, Ren-Jei Chung
Summary: In this study, metal-organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires were synthesized using a one-pot hydrothermal approach with dopamine as the reducing agent. The nanowires were coated with polydopamine (PDA) for enhanced photothermal effects and NIR absorption. The PDA-coated Cu-BTC NWs showed high photothermal conversion efficiency and stability, and also exhibited potential as MRI contrast agents. Cellular uptake studies demonstrated increased uptake of Cu-BTC@PDA NWs into cancer cells, and in vitro studies showed significant therapeutic effects with laser irradiation. These findings suggest that copper-based nanowires have great potential as theranostic agents for cancer treatment.
Article
Materials Science, Multidisciplinary
Chen Ni, Jiahui Lu, Zhian Chen, Jinfeng Yang, Jie Huang, Xinyi Guo, Meilin Shi
Summary: Photothermal therapy (PTT) has been widely studied as a treatment for superficial tumors. However, traditional PTT methods often require high temperatures to effectively destroy tumors, resulting in damage to normal tissues and inflammatory responses. To address these issues, a novel concave mesoporous polydopamine-targeting nanotherapeutic agent was developed. This agent demonstrated good biocompatibility, strong targeting abilities, and low toxicity. It could be used for hyaluronic acid targeting, mesoporous polydopamine thermotherapy, autophagy inhibitor sensitization thermotherapy, and elimination of inflammation induced by photothermal therapy, leading to improved efficiency of mild photothermal therapy for cancer treatment.
MATERIALS & DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Dong An, Xin Wu, Yaolin Gong, Wenlu Li, Guidong Dai, Xiaofei Lu, Liangmin Yu, Wen Xiu Ren, Meng Qiu, Jian Shu
Summary: A new nanoplatform has been developed in this study, which combines manganese ions and biocompatible PEG to give the nanosheets multi-modal functions for thermal therapy and chemodynamic treatment guided by magnetic resonance imaging. The nanosheets can act as contrast agents for T1-weighted MRI and convert cellular H2O2 into highly toxic hydroxyl radicals for chemodynamic therapy.
Article
Engineering, Biomedical
Guohai Liang, Jiamei Han, Da Xing
Summary: The Fe-ZDS complex developed in this study is a dual-functional agent with excellent biocompatibility and efficient renal clearance. It is capable of imaging-guided, precise photothermal therapy of tumors and exhibits higher optical absorption intensity in weakly acidic environments.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Environmental
Wenbao Zuo, Nian Liu, Ziyao Chang, Jinxue Liu, Quanyi Jin, Luping Chen, Xuan Zhu
Summary: This study reports an ultrathin single-site bimetallic nano-sheet (CuCo NS) for mutually-reinforced photothermal therapy (PTT) and chemodynamic therapy (CDT). The CuCo NS possesses superior Fenton-like activities and high photothermal conversion efficiency, enabling simultaneous GSH-depletion and •OH-generation in the tumor microenvironment. Additionally, CuCo NS can serve as a photoacoustic/magnetic resonance imaging contrast agent for real-time monitoring of bio-distribution and treatment progress.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Zhipeng Li, Yadan Ding, Xiaokun Wen, Jianbo Cao, Lin Liu, Huiying Zhao, Xiao-Juan Zhu, Xia Hong
Summary: MnFe2O4 nanoparticle clusters showed satisfactory magnetic resonance/photoacoustic imaging (PAI)-guided photothermal theranostic performance as a promising all-in-one gliomas therapeutic agent. The construction of cluster structure endowed the agent with high T-2-relaxation rate and photothermal conversion efficiency, demonstrating low toxicity and stark contrast effects of magnetic resonance/PAI both in vivo and in vitro. Photothermal therapy led to significant shrinkage or disappearance of ectopic gliomas in mouse models after 16 days.
ACS APPLIED NANO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xun Kang, Tao Sun, Liang Zhang, Chunyu Zhou, Zhongsheng Xu, Mengmeng Du, Shilin Xiao, Yun Liu, Mingfu Gong, Dong Zhang
Summary: Fe3O4-Aushell-PEG NPs, with uniform Janus-like morphology, demonstrated good biocompatibility, promising MRI effects, high transverse relaxivity, and potential photothermal therapy performance, making them a synergistic theranostic agent for breast cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Wen Qin, Jinzhao Huang, Chunsheng Yang, Quer Yue, Shizhen Chen, Mengdie Wang, Shangbang Gao, Xin Zhou, Xiangliang Yang, Yan Zhang
Summary: This study presents a novel activatable ferrous nanotheranostics for spatial-temporal control over antitumor ferroptosis responses. The nanotherapeutics can be guided by photoacoustic and magnetic resonance imaging (MRI), and it can effectively induce tumor cell death through photothermal therapy and Fenton reaction. This treatment not only suppresses tumor growth, but also promotes immune response against the tumor.
ADVANCED FUNCTIONAL MATERIALS
(2023)
