A Spleen Tyrosine Kinase’s Sky in Neuronal Degeneration

Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis

(2023) Hannah Ennerfelt et al.   Clinical and Translational Medicine

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

(2023) Yumeng Wang et al.   Journal of Neuroinflammation

Microglia Share the Burden

(2022) Qian Wang et al.   Neuroscience Bulletin

Microglia-Mediated Aβ Propagation in Alzheimer’s Disease

(2022) Luoman Yang et al.   Neuroscience Bulletin

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

(2022) Hannah Ennerfelt et al.   CELL

TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

(2022) Shoutang Wang et al.   CELL

Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice

(2020) Xin-Chun Ye et al.   Journal of Neuroinflammation

Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures

(2020) Jonas Elias Schweig et al.   NEUROSCIENCE LETTERS

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo

(2019) Jonas Elias Schweig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Down-Regulation Of Mir-107 Worsen Spatial Memory By Suppressing SYK Expression And Inactivating NF-ΚB Signaling Pathway

(2018) Wenjie Hu et al.   Current Alzheimer Research

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

(2017) Johnathan Cooper-Knock et al.   Acta Neuropathologica Communications

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

(2015) Yue He et al.   STROKE

Jedi-1 and MEGF10 Signal Engulfment of Apoptotic Neurons through the Tyrosine Kinase Syk

(2012) J. L. Scheib et al.   JOURNAL OF NEUROSCIENCE