Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia

Survival Genie, a web platform for survival analysis across pediatric and adult cancers

(2022) Bhakti Dwivedi et al.   Scientific Reports

Mesothelin: An Immunotherapeutic Target beyond Solid Tumors

(2022) Joshua R. Faust et al.   Cancers

Whole-genome sequencing as an alternative to analyze copy number abnormalities in AML, MDS and MM.

(2022) Xiaodong Lyu et al.   JOURNAL OF CLINICAL ONCOLOGY

CD74 is a regulator of hematopoietic stem cell maintenance

(2021) Shirly Becker-Herman et al.   PLOS BIOLOGY

Treatment of acute myeloid leukemia in children: A practical perspective

(2021) Grace Egan et al.   PEDIATRIC BLOOD & CANCER

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

(2021) Xueping Li et al.   Frontiers of Medicine

Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression

(2021) L. C. Stetson et al.   LEUKEMIA

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer

(2021) Yonggang Liu et al.   MOLECULAR BIOLOGY REPORTS

Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers

(2020) Miao Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

(2020) Ana Rio-Machin et al.   Nature Communications

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective

(2020) Mei Shan Ong et al.   Cancers

Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML

(2020) Yoko Tabe et al.   Frontiers in Oncology

Aberrant TRPM4 expression in MLL-rearranged acute myeloid leukemia and its blockade induces cell cycle arrest via AKT/GLI1/Cyclin D1 pathway

(2020) Fujue Wang et al.   CELLULAR SIGNALLING

Risk associated alterations in marrow T cells in pediatric leukemia

(2020) Jithendra Kini Bailur et al.   JCI Insight

Immunogenomic Landscape of Hematological Malignancies

(2020) Olli Dufva et al.   CANCER CELL

A single-cell survey of cellular hierarchy in acute myeloid leukemia

(2020) Junqing Wu et al.   Journal of Hematology & Oncology

A Transcriptomics-Based Meta-Analysis Combined With Machine Learning Identifies a Secretory Biomarker Panel for Diagnosis of Pancreatic Adenocarcinoma

(2020) Indu Khatri et al.   Frontiers in Genetics

DNA Methylation Clusters and Their Relation to Cytogenetic Features in Pediatric AML

(2020) Jatinder K. Lamba et al.   Cancers

CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro

(2020) Xiaolei Yao et al.   REPRODUCTION

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer

(2019) Ghaneya Al-Khadairi et al.   Journal of Translational Medicine

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

High IFITM3 expression predicts adverse prognosis in acute myeloid leukemia

(2019) Yan Liu et al.   CANCER GENE THERAPY

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

(2019) Hannah Wurzer et al.   Cells

Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling

(2019) Zhongqiu Wei et al.   EXPERIMENTAL CELL RESEARCH

Clinical Significance of SERPINA1 Gene and Its Encoded Alpha1-antitrypsin Protein in NSCLC

(2019) Ercetin et al.   Cancers

A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia

(2019) Abdelrahman H. Elsayed et al.   LEUKEMIA

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia

(2019) Cécile K. Lopez et al.   Cancer Discovery

A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer

(2018) Jon Peñarando et al.   BMC BIOLOGY

The filamin-B–refilin axis – spatiotemporal regulators of the actin-cytoskeleton in development and disease

(2018) Jacques Baudier et al.   JOURNAL OF CELL SCIENCE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Dual-specificity MAP kinase phosphatases in health and disease

(2018) Ole-Morten Seternes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells

(2018) Yukiyoshi Mita et al.   INTERNATIONAL IMMUNOLOGY

Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

(2018) Xiaotu Ma et al.   NATURE

Identification of genes which regulate stroma-dependent in vitro hematopoiesis

(2018) Pravin Periasamy et al.   PLoS One

Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells

(2018) Yixiang Han et al.   Frontiers in Immunology

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

(2018) Mi Deng et al.   NATURE

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

(2018) Jiahao Chen et al.   NATURE MEDICINE

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

(2018) Matthew J. Christopher et al.   NEW ENGLAND JOURNAL OF MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

(2018) Shahzya Chaudhury et al.   Nature Communications

Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemia

(2017) Chien-Chin Lin et al.   HAEMATOLOGICA

The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments

(2017) Janna Schneppenheim et al.   JOURNAL OF IMMUNOLOGY

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

(2017) Hamid Bolouri et al.   NATURE MEDICINE

Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines

(2017) Haitao Bai et al.   TUMOR BIOLOGY

Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemia

(2017) Chien-Chin Lin et al.   HAEMATOLOGICA

Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

(2017) Xiao Yang et al.   OncoImmunology

Microtubule destabilising agents: far more than just antimitotic anticancer drugs

(2016) Darcy Bates et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia

(2016) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Harnessing the immune system in acute myeloid leukaemia

(2016) Rebecca Austin et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

(2016) Y. S. Al-Matary et al.   HAEMATOLOGICA

CD74 is a novel transcription regulator

(2016) Naama Gil-Yarom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity

(2016) Xilong Xu et al.   Science China-Life Sciences

Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier

(2016) Manoj K. Bhasin et al.   Oncotarget

Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter

(2016) Farzad S. Forootan et al.   Oncotarget

Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

(2016) Y. S. Al-Matary et al.   HAEMATOLOGICA

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow

(2015) Kentaro Yoshioka et al.   PLoS One

Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B

(2014) H Itonaga et al.   LEUKEMIA

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF- -SMAD3 pathway in non-small cell lung adenocarcinoma

(2014) M. Risolino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Knock-Down of PRAME Increases Retinoic Acid Signaling and Cytotoxic Drug Sensitivity of Hodgkin Lymphoma Cells

(2013) Stefanie Kewitz et al.   PLoS One

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

(2011) Vanesa Lafarga et al.   EMBO JOURNAL

RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape

(2011) O. Gay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of Multiple Similar Ligand-binding Repeats in Filamin

(2009) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH