Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

(2014) Melvin Andersen   ALTEX-Alternatives to Animal Experimentation

Influence of DNA Repair on Nonlinear Dose-Responses for Mutation

(2013) Adam D. Thomas et al.   TOXICOLOGICAL SCIENCES

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Micronucleus and its applications

(2011) Swapan Samanta et al.   DIAGNOSTIC CYTOPATHOLOGY

Stimulus-dependent dynamics of p53 in single cells

(2011) E. Batchelor et al.   Molecular Systems Biology

Evidence for hormesis in mutagenicity dose–response relationships

(2011) Edward J. Calabrese et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Study of oxidative DNA damage in TK6 human lymphoblastoid cells by use of the thymidine kinase gene-mutation assay and the in vitro modified comet assay: Determination of No-Observed-Genotoxic-Effect-Levels

(2011) Anne Platel et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Role of p53 Serine 46 in p53 Target Gene Regulation

(2011) Leonie Smeenk et al.   PLoS One

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

(2011) T. Neumaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

(2011) Wenjian Ma et al.   PLoS Genetics

Cistrome: an integrative platform for transcriptional regulation studies

(2011) Tao Liu et al.   GENOME BIOLOGY

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate

(2010) Teodora Nikolova et al.   DNA REPAIR

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing

(2010) Qiang Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Potential thresholds for genotoxic effects by micronucleus scoring

(2010) A. Elhajouji et al.   MUTAGENESIS

Cross talk between stimulated NF-κB and the tumor suppressor p53

(2010) G Schneider et al.   ONCOGENE

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Mdm2 Affects Genome Stability Independent of p53

(2009) A. Bouska et al.   CANCER RESEARCH

Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU

(2009) Lynn H. Pottenger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis

(2009) George E. Johnson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU

(2009) Elmar Gocke et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose–response relationships, exemplified for mutagenicity data

(2009) Werner K. Lutz et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactome knowledgebase of human biological pathways and processes

(2008) L. Matthews et al.   NUCLEIC ACIDS RESEARCH

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels

(2007) Kyungmi Min et al.   FOOD AND CHEMICAL TOXICOLOGY