Review
Cell Biology
Eunhee Kim, Dong Min Lee, Min Ji Seo, Hong Jae Lee, Kyeong Sook Choi
Summary: Paraptosis is a type of programmed cell death characterized by dilation of the endoplasmic reticulum and/or mitochondria. Ca2+ transport has been shown to play an important role in paraptosis induced by various agents, and perturbations of cellular proteostasis and ion homeostasis are believed to contribute critically to the process. The communication between the ER and mitochondria mediated by Ca2+ appears to be crucial in inducing paraptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Benjamin Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, Maria E. Andres, Patrick Yu-Wai-Man, Gyoergy Hajnoczky, Veronica Eisner
Summary: Autosomal Dominant Optic Atrophy (ADOA), caused by OPA1 mutations, affects Ca2+ homeostasis by modulating ER-mitochondria coupling, potentially contributing to the progression of ADOA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Nan Wang, Chong Wang, Hongyang Zhao, Yichun He, Beiwu Lan, Liankun Sun, Yufei Gao
Summary: The cooperation and antagonism between organelles within the cell play a crucial role in maintaining cellular homeostasis. The signaling crosstalk between the endoplasmic reticulum (ER) and mitochondria influences cell fate. Mitochondria-associated membranes (MAMs) are pivotal in regulating lipid synthesis, calcium homeostasis, ER-mitochondrial coordination, and death signal transduction, contributing to cell death mechanisms such as apoptosis.
Article
Multidisciplinary Sciences
Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, Ying Hu
Summary: The study demonstrates the interaction between TMCO1 and iASPP in colon cancer, affecting tumor growth and cell apoptosis by modulating Ca2+ homeostasis. Intervention in the iASPP-TMCO1 axis can effectively inhibit tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Mohammad A. Ghane, Wei Wei, Dina W. Yakout, Zachary D. Allen, Cassandra L. Miller, Bin Dong, Jenny J. Yang, Ning Fang, Angela M. Mabb
Summary: The study found that disrupting Arc protein ubiquitination enhances DHPG-induced ER-mediated Ca2+ release. This alteration is observed in all neuronal subregions except secondary branchpoints. Disruptions in Arc ubiquitination increase Arc interaction with the integral ER protein Calnexin.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jinhong Wei, Wenting Guo, Ruiwu Wang, John Paul Estillore, Darrell Belke, Yong-Xiang Chen, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, S. R. Wayne Chen
Summary: The physiological significance of PKA phosphorylation of RyR2 in the heart is still poorly understood. Recent structural studies have shown that the PKA phosphorylation site S2030 in RyR2 is located within a pathway that is important for the termination of Ca2+ release. We investigated the impact of S2030 mutations on Ca2+ release termination in cells and generated a mouse model to study the role of S2030 in a physiological setting.
CIRCULATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xintong Bian, Ningke Fan, Meng Li, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song, Siqiao Li, Wei Cheng
Summary: A hepatocellular carcinoma (HCC) cell-derived ER vesicle (ER-horse) has been developed for precise HCC nanotherapy by imitating the physiological function of endoplasmic reticulum (ER) and triggering excessive ER stress and apoptosis. The findings provide a new method for HCC nanotherapy via interference of ER stress signaling.
Article
Physiology
Lianguo Wang, Rachel C. Myles, I-Ju Lee, Donald M. Bers, Crystal M. Ripplinger
Summary: The study demonstrates that inhibition of SERCA can slow down SR Ca2+ reuptake, leading to an increase in the magnitude of Ca2+ alternans in cardiac cells, especially at fast pacing frequencies. Notably, the alternation of SR Ca2+ release precedes the alternation of SR Ca2+ load during rapid ventricular pacing.
FRONTIERS IN PHYSIOLOGY
(2021)
Editorial Material
Cell Biology
Karim Rahhali, Fabio Di Lisa, Nina Kaludercic
Summary: The close contacts between the endoplasmic reticulum and mitochondria are crucial for various cell functions. A recent article in Nature Communications demonstrated that motile IP(3)Rs can quickly transfer Ca2+ at ERMCs, thereby stimulating mitochondrial oxidative metabolism.
Article
Multidisciplinary Sciences
Lauren C. Panzera, Ben Johnson, Josiah A. Quinn, In Ha Cho, Michael M. Tamkun, Michael B. Hoppa
Summary: Research indicates that Kv2.1 channels play a crucial role in facilitating ER calcium uptake during electrical activity in neurons, which is related to synaptic transmission. Loss of the Kv2.1 channel can disrupt synaptic vesicle fusion during stimulation, while its non-conducting role can link ER calcium uptake with electrical activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Francesca Resentini, Matteo Grenzi, Daniele Ancora, Mara Cademartori, Laura Luoni, Marianna Franco, Andrea Bassi, Maria Cristina Bonza, Alex Costa
Summary: The study utilizes genetically encoded Ca2+ indicators to reveal details of Ca2+ dynamics in plant cells, including the processing time of Ca2+ from the cytosol to the ER and the time to observe cytosolic Ca2+ increase with ER inhibition. Live imaging of mature plants also shows a wounding-induced long-distance ER Ca2+ wave, enhancing the understanding of intracellular Ca2+ dynamics and signaling.
Article
Cell Biology
Toyokazu Kimura, Kazuki Kagami, Atsushi Sato, Ayumu Osaki, Kei Ito, Shunpei Horii, Takumi Toya, Nobuyuki Masaki, Risako Yasuda, Yuji Nagatomo, Takeshi Adachi
Summary: This study found that SERCA2 protein expression decreased in the aorta of diabetic mice, and CDN1163 improved aortic endothelial dysfunction, glucose tolerance, hepatosteatosis, and skeletal muscle function in these mice.
Article
Pharmacology & Pharmacy
Juan Ignacio Elio Mariangelo, Carlos Alfredo Valverde, Leticia Vittone, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study found that blocking ER calcium efflux via the translocon can suppress ER stress and improve the mechanical performance and diastolic calcium handling of stunned myocardium. Therefore, modulation of translocon permeability may be a therapeutic approach to treat the functional abnormalities caused by ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Motonori Matsusaki, Kimiko Kuroki, Hiroshi Yamaguchi, Katsumi Maenaka, Young-Ho Lee, Kenji Inaba, Masaki Okumura
Summary: ERp57, a member of the protein disulfide isomerase family, functions as a key disulfide catalyst in the oxidative folding of proteins in the ER. It forms a complex with ER lectin-like chaperones calnexin, and under abnormal physiological conditions such as Ca2+ depletion, this complex effectively guides proper oxidative protein folding by performing both enzymatic and chaperoning functions.
Article
Biochemistry & Molecular Biology
Xuan Xiong, Xiaoqin Zhang, Yuan Zhang, Jiaqi Xie, Yuan Bian, Qinan Yin, Rongsheng Tong, Dongke Yu, Lingai Pan
Summary: This study found that TCEP exposure can cause cardiac fibrosis by inhibiting the expression of SERCA and leading to Ca2+ overload, which in turn triggers ER stress and overactive autophagy. The results reveal the important role of the Ca2+ overload/ER stress/autophagy axis in TCEP-induced cardiotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Editorial Material
Cell Biology
J. Prudent, N. Popgeorgiev, B. Bonneau, G. Gillet
CELL DEATH & DISEASE
(2015)
Article
Oncology
Adrien Nougarede, Nikolay Popgeorgiev, Loay Kassem, Soleilmane Omarjee, Stephane Borel, Ivan Mikaelian, Jonathan Lopez, Rudy Gadet, Olivier Marcillat, Isabelle Treilleux, Bruno O. Villoutreix, Ruth Rimokh, Germain Gillet
Article
Virology
Nikolay Popgeorgiev, Sarah Temmam, Didier Raoult, Christelle Desnues
Article
Ecology
Laura Fancello, Sebatien Trape, Catherine Robert, Mickael Boyer, Nikolay Popgeorgiev, Didier Raoult, Christelle Desnues
Article
Multidisciplinary Sciences
Laura Fancello, Sonia Monteil, Nikolay Popgeorgiev, Romain Rivet, Frederique Gouriet, Pierre-Edouard Fournier, Didier Raoult, Christelle Desnues
Article
Biochemistry & Molecular Biology
Benjamin Bonneau, Adrien Nougarede, Julien Prudent, Nikolay Popgeorgiev, Nadine Peyrieras, Ruth Rimokh, Germain Gillet
Article
Multidisciplinary Sciences
Julien Prudent, Nikolay Popgeorgiev, Rudy Gadet, Mathieu Deygas, Ruth Rimokh, Germain Gillet
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Margaux Bessou, Jonathan Lopez, Rudy Gadet, Mathieu Deygas, Nikolay Popgeorgiev, Delphine Poncet, Adrien Nougarede, Pauline Billard, Ivan Mikaelian, Philippe Gonzalo, Ruth Rimokh, Germain Gillet
Article
Cell Biology
Kevin Berthenet, Camila Castillo Ferrer, Deborah Fanfone, Nikolay Popgeorgiev, David Neves, Philippe Bertolino, Benjamin Gibert, Hector Hernandez-Vargas, Gabriel Ichim
Article
Multidisciplinary Sciences
Nikolay Popgeorgiev, Jaison D. Sa, Lea Jabbour, Suresh Banjara, Trang Thi Minh Nguyen, Aida Akhavan-E-Sabet, Rudy Gadet, Nikola Ralchev, Stephen Manon, Mark G. Hinds, Hans-Jurgen Osigus, Bernd Schierwater, Patrick O. Humbert, Ruth Rimokh, Germain Gillet, Marc Kvansakul
Review
Biochemistry & Molecular Biology
Jordan L. Morris, Germain Gillet, Julien Prudent, Nikolay Popgeorgiev
Summary: Bcl-2 family proteins are not only important regulators of apoptosis, but are also emerging as regulators of intracellular calcium concentrations. They interact with major calcium transporters at mitochondria-ER contact points, controlling mitochondrial calcium balance and impacting cell survival and migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Trang Thi Minh Nguyen, Germain Gillet, Nikolay Popgeorgiev
Summary: The caspase family of cysteine proteases plays critical roles in shaping embryonic structures, particularly in the development of the central nervous system (CNS). Apart from their involvement in apoptosis, caspases are also implicated in various other neurodevelopmental processes, raising questions about how neurons regulate the decision-making between cell death and proper development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Nadine Martin, Nikolay Popgeorgiev, Gabriel Ichim, David Bernard
Summary: In this Comment, the authors highlight the non-apoptotic roles of BCL-2 proteins in regulating cellular senescence and caution against the use of BCL-2 inhibitors as senolytics. While BCL-2 and related proteins are known for their role in apoptosis regulation, recent findings suggest their involvement in cellular senescence through non-apoptotic mechanisms.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Cell Biology
Nikolay Popgeorgiev, Lea Jabbour, Germain Gillet
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)