The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1

Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy

(2022) Madhulika Tripathi et al.   Autophagy

Mechanism of METTL3-Mediated m6A Modification in Cardiomyocyte Pyroptosis and Myocardial Ischemia–Reperfusion Injury

(2022) Xiang Wang et al.   CARDIOVASCULAR DRUGS AND THERAPY

BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

(2022) Yue Chen et al.   PHARMACOLOGICAL RESEARCH

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression

(2022) Zhiwei He et al.   Cell Death & Disease

JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells

(2022) Yi He et al.   Clinical Epigenetics

Targeting autophagy in aortic aneurysm and dissection

(2022) Ze-Min Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Methyltransferase like 3-mediated N6-methylatidin methylation inhibits vascular smooth muscle cells phenotype switching via promoting phosphatidylinositol 3-kinase mRNA decay

(2022) Yongchao Zhao et al.   Frontiers in Cardiovascular Medicine

Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation

(2022) Ze‐Min Fang et al.   CELL PROLIFERATION

Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

(2022) Fu-Qing Jiang et al.   eLife

Phospho-regulation and Function of ULK1-ATG13 During the Cell Cycle

(2021) Zhiyuan Li et al.   Autophagy

RNA Modification by m6A Methylation in Cardiovascular Disease

(2021) Jun Chen et al.   Oxidative Medicine and Cellular Longevity

METTL3 attenuates proliferative vitreoretinopathy and epithelial‐mesenchymal transition of retinal pigment epithelial cells via wnt/β‐catenin pathway

(2021) Xinqi Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury

(2021) Rui Gong et al.   PHARMACOLOGICAL RESEARCH

Downregulation of Filamin a Expression in the Aorta Is Correlated With Aortic Dissection

(2021) Yue Chen et al.   Frontiers in Cardiovascular Medicine

Targeting regulated cell death in aortic aneurysm and dissection therapy

(2021) Yue Chen et al.   PHARMACOLOGICAL RESEARCH

mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation

(2021) Hong Huang et al.   Nature Communications

Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension

(2021) Yong-Jie Chen et al.   Frontiers in Pharmacology

METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner

(2021) Kun Zhao et al.   Cell Death Discovery

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors

(2020) Jiaying Lin et al.   Stem Cells International

Induction of autophagy and suppression of type I IFN secretion by CSFV

(2020) Baoming Xie et al.   Autophagy

Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP/p16 signals via m6A modulation

(2020) Boqian Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury

(2020) Shanshan Gu et al.   CIRCULATION RESEARCH

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle

(2020) Zhiyuan Li et al.   PLOS BIOLOGY

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

(2020) Chengwu Zeng et al.   Journal of Hematology & Oncology

Protein methylation functions as the posttranslational modification switch to regulate autophagy

(2019) Rui Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

(2019) Ru Deng et al.   OncoTargets and Therapy

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

(2019) Richard I. Odle et al.   MOLECULAR CELL

EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection

(2018) Rui Li et al.   Cell Death & Disease

The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway

(2018) Hongfei Wu et al.   Frontiers in Pharmacology

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination

(2017) Lorenza Sisinni et al.   JOURNAL OF PATHOLOGY

AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia

(2017) Arwa Fairaq et al.   PHARMACOLOGICAL RESEARCH

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of Everolimus-Eluting and Sirolimus-Eluting Coronary Stents

(2012) Takeshi Kimura et al.   CIRCULATION