Salvianolic acid A alleviates cardiovascular injury in rats with chronic kidney disease by activating the PI3K/Akt/Nrf2/HO-1 and SIRT1/TLR4/NF-κB/P38 signaling pathways

Bupi Yishen Formula Versus Losartan for Non-Diabetic Stage 4 Chronic Kidney Disease: A Randomized Controlled Trial

(2021) Wei Mao et al.   Frontiers in Pharmacology

The pathogenesis of CKD complications; Attack of dysregulated iron and phosphate metabolism

(2020) Takeshi Nakanishi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms

(2020) Yalan Wu et al.   Oxidative Medicine and Cellular Longevity

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats

(2019) Hong-feng Zhang et al.   Oxidative Medicine and Cellular Longevity

Fu Brick Tea Alleviates Chronic Kidney Disease of Rats with High Fat Diet Consumption through Attenuating Insulin Resistance in Skeletal Muscle

(2019) Haiping Du et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability:an In Vitro and In Vivo Study

(2019) Fiorelli et al.   Cells

Risk of Progression of Nonalbuminuric CKD to End-Stage Kidney Disease in People With Diabetes: The CRIC (Chronic Renal Insufficiency Cohort) Study

(2018) Digsu N. Koye et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways

(2018) Xiangsheng Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4

(2018) Kexin Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Klotho protein inhibits H2O2-induced oxidative injury in endothelial Cells via regulation of PI3K/Akt/Nrf2/HO-1 Pathways.

(2018) wei cui et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

(2018) Kempaiah Rayavara et al.   JOURNAL OF IMMUNOLOGY

Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

(2018) Shaonan Hu et al.   MOLECULES

Cardiovascular Biomarkers in Association with Dietary Intake in a Longitudinal Study of Youth with Type 1 Diabetes

(2018) Namrata Sanjeevi et al.   Nutrients

Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells

(2017) Hao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

(2017) Vamshi K.C. Nimmagadda et al.   JOURNAL OF NEUROIMMUNOLOGY

Epidemiology: The global burden of reduced GFR: ESRD, CVD and mortality

(2017) Shilpa Sharma et al.   Nature Reviews Nephrology

Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics

(2016) Omar Emiliano Aparicio-Trejo et al.   BIOFACTORS

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway

(2016) Liu Tongqiang et al.   Oxidative Medicine and Cellular Longevity

Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling

(2016) Bin Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of sirtuins in cardiac disease

(2015) Shouji Matsushima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs

(2015) Bin Liang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

(2015) Li-Chin Sung et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

(2015) Yang Bai et al.   Oxidative Medicine and Cellular Longevity

Role of NADPH Oxidase in Total Salvianolic Acid Injection Attenuating Ischemia-Reperfusion Impaired Cerebral Microcirculation and Neurons: Implication of AMPK/Akt/PKC

(2014) Hao Tang et al.   MICROCIRCULATION

Salvia miltiorrhizacompounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells

(2014) Shuqiang Yue et al.   PHARMACEUTICAL BIOLOGY

Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice

(2014) Tingting Zhang et al.   PHYTOMEDICINE

In silicoanalysis and experimental validation of molecular mechanisms of salvianolic acid A-inhibited LPS-stimulated inflammation, in RAW264.7 macrophages

(2013) J. Huang et al.   CELL PROLIFERATION

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Telmisartan Protects against Vascular Dysfunction with Peroxisome Proliferator-Activated Receptor-γ Activation in Hypertensive 5/6 Nephrectomized Rats

(2013) Hiroe Toba et al.   PHARMACOLOGY

Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS

(2011) Luan-luan Yang et al.   ACTA PHARMACOLOGICA SINICA

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Anti-Inflammatory Gene Therapy for Cardiovascular Disease

(2011) Tetsuya Matoba et al.   CURRENT GENE THERAPY

Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ

(2011) Kwang-Seok Oh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats

(2009) Ming-Kuei Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA