Article
Agriculture, Dairy & Animal Science
Zijuan Wu, Yanyun Yan, Wenli Li, Yali Li, Huansheng Yang
Summary: Early weaning stress impairs intestinal health in piglets. miR-199a has an altered expression profile in piglets during weaning stress and plays a regulatory role in intestinal inflammation. These findings suggest that miR-199a may be used as biomarkers and anti-inflammatory agents in animal health management.
Article
Medicine, Research & Experimental
Erica Dander, Paola Vinci, Stefania Vetrano, Camilla Recordati, Rocco Piazza, Grazia Fazio, Donatella Bardelli, Mattia Bugatti, Francesca Sozio, Andrea Piontini, Sonia Bonanomi, Luca Bertola, Elena Tassistro, Maria Grazia Valsecchi, Stefano Calza, William Vermi, Andrea Biondi, Annalisa Del Prete, Silvano Sozzani, Giovanna D'Amico
Summary: Gastrointestinal graft-versus-host disease (GvHD) is a major complication after allogeneic bone marrow transplantation (allo-BMT). Chemerin, a chemotactic protein, and its receptor CMKLR1 play a role in leukocyte recruitment to inflamed tissues. In this study, chemerin levels were elevated in mice with GvHD, and knockout of CMKLR1 worsened GvHD symptoms and survival. Histological analysis showed severe colitis in CMKLR1 knockout mice, characterized by neutrophil infiltration, tissue damage, and inflammation. Similar findings were observed in transplant recipients and colitis-induced mice. Transferring wild-type monocytes into CMKLR1 knockout mice improved GvHD symptoms by reducing gut inflammation and T cell activation. Furthermore, higher serum chemerin levels were associated with GvHD development in patients. These results suggest that CMKLR1/chemerin pathway may play a protective role in controlling intestinal inflammation and tissue damage in GvHD.
Article
Geriatrics & Gerontology
Rosemary A. Hoffman, Sulan Huang, Geetha Chalasani, Abbe N. Vallejo
Summary: The study found that the absolute numbers of intraepithelial cells (iIEC) and plasmacytoid dendritic cells (pDC) are significantly lower in aged mice compared to young mice, despite an increase in the expression of C-C ligand 25 (CCL25). In both young and aged mice, the proportion and absolute number of intraepithelial pDC decreased during acute endotoxemia induced by lipopolysaccharide (LPS), potentially contributing to inadequate responses to gastrointestinal pathogens in aging.
Article
Pharmacology & Pharmacy
Yewen Xie, Fang Shao, Xuehan Duan, Jun Ding, Yongling Ning, Xiao Sun, Lei Xia, Jie Pan, Jie Chen, Shuyan He, Dong Shen, Chunjian Qi
Summary: Yeast beta-glucan can improve experimental intestinal inflammation and delay the development of colorectal cancer, making it a feasible treatment option for chronic colitis and colorectal cancer in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Abigail R. Basson, Christy Chen, Filip Sagl, Ashley Trotter, Ilya Bederman, Adrian Gomez-Nguyen, Mark S. Sundrud, Sanja Ilic, Fabio Cominelli, Alex Rodriguez-Palacios
Summary: With the rise of human obesity, dietary fats have become the focus of biomedical research. High-fat diets, particularly rich in long-chain saturated fatty acids, have pro-inflammatory effects on multiple organs, while certain saturated fats like lauric and myristic acids may have anti-inflammatory and protective properties. Although some effects observed in epidemiological studies may oversimplify the mechanisms, it is essential to understand the complex interactions between the host, specific fatty acids, and genetics/variations of gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Raquel D. N. Arifa, Camila B. Brito, Talles P. Paula, Renata L. Lima, Zelia Menezes-Garcia, Puebla Cassini-Vieira, Fabricio A. Vilas Boas, Celso M. Queiroz-Junior, Janine M. da Silva, Tarcilia A. da Silva, Luciola S. Barcelos, Caio T. Fagundes, Mauro M. Teixeira, Daniele G. Souza
Summary: Eosinophils play an important role in chemotherapy-induced intestinal mucositis, and inhibiting eosinophils can alleviate inflammation. Evasin-4, a chemokine receptor antagonist, reduces the accumulation of eosinophils and chemotherapy-induced mucositis.
Review
Immunology
Tomoe Yoshikawa, Tomohiro Watanabe, Ken Kamata, Akane Hara, Kosuke Minaga, Masatoshi Kudo
Summary: Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disorder of the pancreas, often associated with systemic IgG4-related disease (IgG4-RD); the activation of M2 macrophages and plasmacytoid dendritic cells (pDCs) plays a crucial role in the development of AIP and IgG4-RD; recent studies suggest a link between alterations in gut microbiota composition and the development of AIP and IgG4-RD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Rui Sun, Xuemei Gu, Chao Lei, Liang Chen, Shenghui Chu, Guangzhong Xu, Mark A. Doll, Yi Tan, Wenke Feng, Leah Siskind, Craig J. McClain, Zhongbin Deng
Summary: This study reveals the critical role of Neutral ceramidase (NcDase) in regulating intestinal immune cells. Lack of NcDase leads to altered composition of intestinal immune cells and impairs the clearance of bacteria in mice. Mechanistically, the generation of sphingosine by NcDase promotes immune response in macrophages. Furthermore, dietary sphingomyelin and inhibition of SphK1 can protect against infection.
Article
Food Science & Technology
Feifei Han, Xia Zhao, Xiang Li, Liyuan Peng, Weilin Liu, Jianzhong Han
Summary: The study demonstrated that LfcinB treatment ameliorated intestinal inflammation and improved mucosal barrier function in colitis rats by reducing disease activity index and attenuating tissue damage. This protective effect of LfcinB may be attributed to its ability to suppress inflammation and restore expression levels of key proteins in the mucosal barrier.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Multidisciplinary Sciences
Won Ho Yang, Julia S. Westman, Douglas M. Heithoff, Markus Sperandio, Jin Won Cho, Michael J. Mahan, Jamey D. Marth
Summary: Intestinal inflammation is the underlying cause of colitis and inflammatory bowel diseases, influenced by genetic and environmental factors. Alteration in neuraminidase activity may trigger disease onset, and inhibition of Neu3 can protect against severe colitis development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Kanchana K. Ayyar, Alan C. Moss
Summary: Exosomes are small vesicles released by cells, containing a variety of molecules, and can be found in various tissues of humans and other mammals. A unique exosome profile can be detected in blood and fecal samples of patients with Inflammatory Bowel Disease (IBD), making them potential targets for IBD therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Sebastian Kjaergaard Hendel, Lauge Kellermann, Annika Hausmann, Niels Bindslev, Kim Bak Jensen, Ole Haagen Nielsen
Summary: Recent years have witnessed a significant increase in interest in intestinal epithelial tuft cells and their roles in basic physiology, immune responses, and gut diseases. Acting as sentinels in the gastrointestinal tract, tuft cells use succinate as well as sweet and bitter taste receptors to monitor intestinal content and respond to stimulation. They secrete a range of effector molecules, including interleukin-25, prostaglandin E-2 and D-2, acetylcholine, etc., which play crucial roles in anti-helminthic and anti-protozoan immunity. Studies on human tuft cells are still limited and further exploration is needed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Mohammed Abdo Yahya, Ghedeir M. Alshammari, Magdi A. Osman, Laila Naif Al-Harbi, Abu El Gasim A. Yagoub, Sahar Abdulaziz Al Sedairy
Summary: Isoliquiritigenin (ISL) can attenuate high-fat diet-induced intestinal damage and inflammation by modulating Nrf2. It improves the structure of the duodenum, reduces oxidative stress and inflammation, and enhances antioxidant enzyme activity to strengthen the intestinal barrier.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Yue Zhang, Takeshi Yamamoto, Shusaku Hayashi, Makoto Kadowaki
Summary: The study demonstrated that Astragaloside IV (As-IV) and oxymatrine (Oxy) can ameliorate colitis by suppressing plasmacytoid dendritic cell (pDCs) migration, suggesting a potential therapeutic approach for colonic inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Jutapon Chayapong, Harishkumar Madhyastha, Radha Madhyastha, Queen Intan Nurrahmah, Yuichi Nakajima, Narantsog Choijookhuu, Yoshitaka Hishikawa, Masugi Maruyama
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Multidisciplinary Sciences
Arata Honda, Narantsog Choijookhuu, Haruna Izu, Yoshihiro Kawano, Mizuho Inokuchi, Kimiko Honsho, Ah-Reum Lee, Hiroki Nabekura, Hiroshi Ohta, Tomoyuki Tsukiyama, Yasuhide Ohinata, Asato Kuroiwa, Yoshitaka Hishikawa, Mitinori Saitou, Takamichi Jogahara, Chihiro Koshimoto
Article
Cell Biology
Phyu Synn Oo, Yuya Yamaguchi, Akira Sawaguchi, Myat Tin Htwe Kyaw, Narantsog Choijookhuu, Mohmand Noor Ali, Naparee Srisowanna, Shin-ichiro Hino, Yoshitaka Hishikawa
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2018)
Article
Cell Biology
Mohmand Noor Ali, Narantsog Choijookhuu, Hideaki Takagi, Naparee Srisowanna, Mai Nguyen Nhat Huynh, Yuya Yamaguchi, Phyu Synn Oo, Myat Tin Htwe Kyaw, Katsuaki Sato, Ryoji Yamaguchi, Yoshitaka Hishikawa
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2018)
Article
Allergy
Tomofumi Uto, Hideaki Takagi, Tomohiro Fukaya, Junta Nasu, Takehito Fukui, Noriaki Miyanaga, Keiichi Arimura, Takeshi Nakamura, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Deokcheol Lee, Noboru Taniguchi, Katsuaki Sato, Narantsog Choijookhuu, Yoshitaka Hishikawa, Hiroaki Kataoka, Hidetaka Morinaga, Martin Lotz, Etsuo Chosa
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Arata Honda, Yoshihiro Kawano, Haruna Izu, Narantsog Choijookhuu, Kimiko Honsho, Tomonori Nakamura, Yukihiro Yabuta, Takuya Yamamoto, Yasuhiro Takashima, Michiko Hirose, Tadashi Sankai, Yoshitaka Hishikawa, Atsuo Ogura, Mitinori Saitou
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Myat Tin Htwe Kyaw, Yuya Yamaguchi, Narantsog Choijookhuu, Koichi Yano, Hideaki Takagi, Nobuyasu Takahashi, Phyu Synn Oo, Katsuaki Sato, Yoshitaka Hishikawa
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2019)
Article
Public, Environmental & Occupational Health
Hitoshi Mochizuki, Khin Phyu Phyu, Myo Nanda Aung, Phyo Wai Zin, Yasunori Yano, Moe Zaw Myint, Win Min Thit, Yuka Yamamoto, Yoshitaka Hishikawa, Kyaw Zin Thant, Masugi Maruyama, Yoshiki Kuroda
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2019)
Article
Multidisciplinary Sciences
Kunwadee Palasin, Tamayo Uechi, Maki Yoshihama, Naparee Srisowanna, Narantsog Choijookhuu, Yoshitaka Hishikawa, Naoya Kenmochi, Wilaiwan Chotigeat
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Jin Matsumoto, Kou Suzuki, Masahide Yasuda, Yuya Yamaguchi, Yoshitaka Hishikawa, Naoya Imamura, Atsushi Nanashima
BIOORGANIC & MEDICINAL CHEMISTRY
(2017)
Article
Developmental Biology
Takashi Nakamura, Takehiko Ueyama, Yuzuru Ninoyu, Hirofumi Sakaguchi, Narantsog Choijookhuu, Yoshitaka Hishikawa, Hiroshi Kiyonari, Masaaki Kohta, Mizuho Sakahara, Ivan de Curtis, Eiji Kohmura, Yasuo Hisa, Atsu Aiba, Naoaki Saito
Article
Cell Biology
Kazuyo Tsuchiya, Takuto Ikeda, Baatarsuren Batmunkh, Narantsog Choijookhuu, Hidenobu Ishizaki, Masayuki Hotokezaka, Yoshitaka Hishikawa, Atsushi Nanashima
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2017)
Article
Cell Biology
Baatarsuren Batmunkh, Narantsog Choijookhuu, Naparee Srisowanna, Uugantsetseg Byambatsogt, Phyu Synn Oo, Mohmand Noor Ali, Yuya Yamaguchi, Yoshitaka Hishikawa
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2017)